Cridanimod sodium | CAS#58880-43-6 | IFN inducer

MedKoo Cat#: 562223 | Name: Cridanimod sodium

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cridanimod, also known as XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.

Chemical Structure

Cridanimod sodium

CAS#58880-43-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 562223

Name: Cridanimod sodium

CAS#: 58880-43-6 (sodium)

Chemical Formula: C15H10NNaO3

Exact Mass: 275.0558

Molecular Weight: 275.23

Elemental Analysis: C, 65.46; H, 3.66; N, 5.09; Na, 8.35; O, 17.44

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks

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Related CAS #

58880-43-6 (sodium) 38609-97-1 (free acid)

Synonym

Cridanimod sodium; Cridanimod Na; Sodium Cridanimod; XBIO101; XBIO-101; XBIO 101; Cycloferon; Cyclopheron; Camedon; Camedone; Neovir; CMA

IUPAC/Chemical Name

Sodium 2-(9-oxoacridin-10(9H)-yl)acetate

InChi Key

FQMLTEAEJZVTAJ-UHFFFAOYSA-M

InChi Code

InChI=1S/C15H11NO3.Na/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16;/h1-8H,9H2,(H,17,18);/q;+1/p-1

SMILES Code

O=C([O-])CN(C1=C2C=CC=C1)C3=CC=CC=C3C2=O.[Na+]

Appearance

A crystalline solid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

λmax: 216, 255, 400 nm

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 275.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ding C, Song Z, Shen A, Chen T, Zhang A. Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway. Acta Pharm Sin B. 2020 Dec;10(12):2272-2298. doi: 10.1016/j.apsb.2020.03.001. Epub 2020 Mar 13. PMID: 33354501; PMCID: PMC7745059. 2: Lysenko IM, Romantsov MG. [Syndrome "sickly child"]. Lik Sprava. 2013 Jan- Feb;(1):48-59. Russian. PMID: 23951910. 3: Mazina N, Mazin P, Kovalenko A. [CLINICAL EFFICIENCY OF CYCLOFERON IN CHILDREN AND ADULTS WITH HIV AND/ OR HERPES INFECTION: SYSTEMATIC REVIEW AND META-ANALYSIS]. Georgian Med News. 2018 Sep;(282):121-129. Russian. PMID: 30358555. 4: Lysenko IM, Romantsov MG. [Recurrent respiratory diseases in children]. Antibiot Khimioter. 2013;58(1-2):27-35. Russian. PMID: 24640142. 5: Kramer MJ, Cleeland R, Grunberg E. Antiviral activity of 10-carboxymethyl-9-acridanone. Antimicrob Agents Chemother. 1976 Feb;9(2):233-8. doi: 10.1128/AAC.9.2.233. PMID: 1267425; PMCID: PMC429509. 6: Mazina NK, Sheshunov IV, Mazin PV, Mazin VP, Kovalenko AL, Zaplutanov VA. Klinicheskaia éffektivnost' immunomoduliatora tsikloferona (tabletki) pri virusnykh infektsiiakh organov dykhaniia: rezul'taty sistematicheskogo obzora i metaanaliza [Clinical efficacy of the immunomodulatory agent cycloferon (tablets) in viral respiratory infections: Results of a systematic review and meta-analysis]. Ter Arkh. 2017;89(11):84-92. Russian. doi: 10.17116/terarkh2017891184-92. PMID: 29260751. 7: Alimbarova L. [THE USE OF CYCLOFERON FOR THE TREATMENT AND PREVENTION OF INFLUENZA AND ACUTE RESPIRATORY VIRAL INFECTIONS]. Klin Med (Mosk). 2015;93(3):57-63. Russian. PMID: 26168605. 8: Isakov DV, Isakov VA. [CYCLOFERON: MECHANISM OF ACTION, AND NEW PROSPECTS FOR APPLICATION IN CLINICAL PRACTICE]. Klin Med (Mosk). 2015;93(9):46-51. Russian. PMID: 27008743. 9: Du H, Kou M, Deng W, Zhou X, Zhang X, Huang Z, Ren B, Cai X, Xu S, Chen Y, Chen L, Chen C, Bao H, Chen Q, Li D. DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1-/- mice. Biomed Pharmacother. 2023 Sep;165:115188. doi: 10.1016/j.biopha.2023.115188. Epub 2023 Jul 20. PMID: 37480829. 10: Alimbarova LM. [Cycloferon and management of herpes virus infection]. Antibiot Khimioter. 2014;59(3-4):22-9. Russian. PMID: 25300118. 11: Tataurschikova NS. Tsikloferon v lokal'noi immunoterapii u patsientov s virus-assotsiirovannym rinitom [Cycloferon in local immunotherapy in patients with virus-associated rhinitis]. Vestn Otorinolaringol. 2021;86(1):78-81. Russian. doi: 10.17116/otorino20218601178. PMID: 33720657. 12: Bazhanova ED. [Role of cycloferon and interferon-alphain apoptosis regulation in neuroendocrinal system on aging]. Eksp Klin Farmakol. 2012;75(10):42-6. Russian. PMID: 23240158. 13: Romantsov MG, Ershov FI, Kovalenko AL, Belova OG. [The therapeutic efficacy of cycloferon and the pharmacological activity of interferon inducers]. Ter Arkh. 2014;86(1):83-8. Russian. PMID: 24754075. 14: Bazhanova ED. [Cycloferon: mechanism of action, functions and application]. Eksp Klin Farmakol. 2012;75(7):40-4. Russian. PMID: 23025052. 15: Gorse GJ, Slater LM, Kaplan HS, Tilles JG, Cesario TC. Inhibition of interferon yield by vincristine. Proc Soc Exp Biol Med. 1984 Mar;175(3):309-13. doi: 10.3181/00379727-175-41800. PMID: 6694980. 16: Romantsov MG, Tikhomirova OV. [Correction of immunity disorders, treatment of intestinal infections and disbiosis in children (clinical review)]. Antibiot Khimioter. 2010;55(5-6):41-9. Russian. PMID: 21033474. 17: Bazhanova ED, Sukhanov DS, Teplyi DL. Pathways of apoptosis regulation in hepatocytes induced by first-line antitubercular drugs. Bull Exp Biol Med. 2015 Mar;158(5):650-3. doi: 10.1007/s10517-015-2828-6. Epub 2015 Mar 17. PMID: 25778653. 18: Romantsov MG, Lysenko IM, Mel'nikova IIu. [Pharmacological prophylaxis and treatment of recidivating respiratory disorders in children]. Eksp Klin Farmakol. 2014;77(1):38-42. Russian. PMID: 24649601. 19: Romantsov MG, Ershov FI, Kovalenko AL, Sukhanov DS, Liberanskaia OM. [Virus infections and interferon inducers in the complex therapy]. Antibiot Khimioter. 2013;58(5-6):49-54. Russian. PMID: 24757825. 20: Yu Y, Yang W, Bilotta AJ, Yu Y, Zhao X, Zhou Z, Yao S, Xu J, Zhou J, Dann SM, Li Y, Cong Y. STING controls intestinal homeostasis through promoting antimicrobial peptide expression in epithelial cells. FASEB J. 2020 Nov;34(11):15417-15430. doi: 10.1096/fj.202001524R. Epub 2020 Sep 24. PMID: 32969062; PMCID: PMC7606834.