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MedKoo Cat#: 341128 | Name: YC 170

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YC 170 is a biochemical.

Chemical Structure

YC 170
YC 170
CAS#59946-73-5

Theoretical Analysis

MedKoo Cat#: 341128

Name: YC 170

CAS#: 59946-73-5

Chemical Formula: C28H26ClN3O3

Exact Mass: 487.1663

Molecular Weight: 487.98

Elemental Analysis: C, 68.92; H, 5.37; Cl, 7.26; N, 8.61; O, 9.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
YC 170; YC-170; YC170
IUPAC/Chemical Name
3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-5-((phenylamino)carbonyl)-, 2-(2-pyridinyl)ethyl ester
InChi Key
YGKDFWHVQNDMLG-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H26ClN3O3/c1-18-24(27(33)32-21-11-4-3-5-12-21)26(22-13-6-7-14-23(22)29)25(19(2)31-18)28(34)35-17-15-20-10-8-9-16-30-20/h3-14,16,26,31H,15,17H2,1-2H3,(H,32,33)
SMILES Code
CC1=C(C(C(=C(N1)C)C(=O)OCCc2ccccn2)c3ccccc3Cl)C(=O)Nc4ccccc4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 487.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takeda Y, Tohse N, Nakaya H, Kanno M. Voltage-dependence of Ca2+ agonist effect of YC-170 on cardiac L-type Ca2+ channels. Br J Pharmacol. 1995 Oct;116(3):2134-40. PubMed PMID: 8640356; PubMed Central PMCID: PMC1908931. 2: Ichida S, Wada T, Matsuda N, Nakazaki S. Effects of Ca channel agonists on 45Ca uptake differ depending on the state of NG108-15 cells. Jpn J Pharmacol. 1994 Mar;64(3):209-12. PubMed PMID: 8022122. 3: Yamamoto T, Tokoro T, Eto Y. The attenuated elevation of cytoplasmic calcium concentration following the uptake of low density lipoprotein in type C Niemann-Pick fibroblasts. Biochem Biophys Res Commun. 1994 Jan 28;198(2):438-44. PubMed PMID: 8297353. 4: Takeda Y. [Single channel analysis of Ca2+ channel-agonistic action of dihydropyridine derivatives: voltage-dependent effects of YC-170 and BAY K 8644]. Hokkaido Igaku Zasshi. 1993 Jul;68(4):557-69. Japanese. PubMed PMID: 7687975. 5: Yano S, Horiuchi H, Horie S, Aimi N, Sakai S, Watanabe K. Ca2+ channel blocking effects of hirsutine, an indole alkaloid from Uncaria genus, in the isolated rat aorta. Planta Med. 1991 Oct;57(5):403-5. PubMed PMID: 1798789. 6: Shibasaki K, Uchida W, Matsuda Y, Asano M. Calcium entry blocking, beta 1-adrenoceptor blocking and hypotensive effects of YM-16151-4. Arch Int Pharmacodyn Ther. 1991 Sep-Oct;313:140-50. PubMed PMID: 1687772. 7: Ichida S, Ariyoshi S, Fujisue T, Wada T, Akimoto T. Effects of calcium channel agonists (BAY K 8644, CGP28392 and YC-170) on 45Ca uptake by rat uterine segments. Jpn J Pharmacol. 1991 Aug;56(4):397-402. PubMed PMID: 1720823. 8: Ogawa N. Effect of nicardipine on the relationship of renal blood flow and of renal vascular resistance to perfusion pressure in dog kidney. J Pharm Pharmacol. 1990 Feb;42(2):138-40. PubMed PMID: 1972402. 9: Higashi H, Sugita S, Matsunari S, Nishi S. Calcium-dependent potentials with different sensitivities to calcium agonists and antagonists in guinea-pig hippocampal neurons. Neuroscience. 1990;34(1):35-47. PubMed PMID: 2325852. 10: Abadie E, Marre M, Race JM, Luis N, Passa P. Vascular and insulinotropic effects of YC 170, a calcium agonist, on isolated perfused rat pancreas. Diabete Metab. 1990 Jan-Feb;16(1):7-10. PubMed PMID: 2185058. 11: Suzuki-Nishimura T, Sano T, Uchida MK. Effects of benzodiazepines on serotonin release from rat mast cells. Eur J Pharmacol. 1989 Aug 11;167(1):75-85. PubMed PMID: 2550260. 12: Lapchak PA, Araujo DM, Collier B. Regulation of endogenous acetylcholine release from mammalian brain slices by opiate receptors: hippocampus, striatum and cerebral cortex of guinea-pig and rat. Neuroscience. 1989;31(2):313-25. PubMed PMID: 2552347. 13: Bechem M, Gross R, Hebisch S, Schramm M. Ca-agonists: a new class of inotropic drugs. Basic Res Cardiol. 1989;84 Suppl 1:105-16. PubMed PMID: 2479372. 14: Takenaka T, Inagaki O, Terai M, Asano M, Kubo K. New 1,4-dihydropyridines with vasoconstrictor action through activation of Ca++-channels. J Pharmacol Exp Ther. 1988 Feb;244(2):699-708. PubMed PMID: 2450201. 15: Kidooka M, Matsuda M, Handa J. Effect of calcium antagonist and agonist on free fatty acid liberation in the ischemic brain of rats. Surg Neurol. 1987 Jul;28(1):41-5. PubMed PMID: 2438789. 16: Nakaya H, Hattori Y, Tohse N, Kanno M. Voltage-dependent effects of YC-170, a dihydropyridine calcium channel modulator, in cardiovascular tissues. Naunyn Schmiedebergs Arch Pharmacol. 1986 Aug;333(4):421-30. PubMed PMID: 2430192. 17: Hattori Y, Nakaya H, Tohse N, Kanno M. Vascular and cardiac effects of a new dihydropyridine derivative, YC-170: a comparison with Bay K 8644. J Pharmacol Exp Ther. 1986 Aug;238(2):670-8. PubMed PMID: 2426442. 18: Schramm M, Towart R. Modulation of calcium channel function by drugs. Life Sci. 1985 Nov 18;37(20):1843-60. Review. PubMed PMID: 2414632. 19: Preuss KC, Gross GJ, Brooks HL, Warltier DC. Slow channel calcium activators, a new group of pharmacological agents. Life Sci. 1985 Oct 7;37(14):1271-8. Review. PubMed PMID: 2413326. 20: Rogg H, Criscione L, Truog A, Meier M. In vitro comparative studies of the calcium-entry activators YC-170, CGP 28392, and BAY K 8644. J Cardiovasc Pharmacol. 1985;7 Suppl 6:S31-7. PubMed PMID: 2414592.

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