MedKoo Cat#: 408107 | Name: RA371
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RA371, a derivative of PTP1B-IN-8 (CAS#919091-61-5), is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor

Chemical Structure

RA371
RA371
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 408107

Name: RA371

CAS#: Unknown

Chemical Formula: C30H23Cl5N2O3

Exact Mass: 634.0151

Molecular Weight: 636.78

Elemental Analysis: C, 56.59; H, 3.64; Cl, 27.84; N, 4.40; O, 7.54

Price and Availability

Size Price Availability Quantity
100mg USD 1,250.00 2 Weeks
200mg USD 1,850.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
No Data
Synonym
RA371; RA-371; RA 371;
IUPAC/Chemical Name
N-((S)-1-(3,5-bis((E)-3,4-dichlorobenzylidene)-4-oxopiperidin-1-yl)-1-oxo-3-phenylpropan-2-yl)-2-chloroacetamide
InChi Key
YPECLOJPAVGDIZ-FODVVNLPSA-N
InChi Code
InChI=1S/C30H23Cl5N2O3/c31-15-28(38)36-27(14-18-4-2-1-3-5-18)30(40)37-16-21(10-19-6-8-23(32)25(34)12-19)29(39)22(17-37)11-20-7-9-24(33)26(35)13-20/h1-13,27H,14-17H2,(H,36,38)/b21-10+,22-11+/t27-/m0/s1
SMILES Code
O=C1/C(CN(C/C1=C\C2=CC=C(C(Cl)=C2)Cl)C([C@H](CC3=CC=CC=C3)NC(CCl)=O)=O)=C/C4=CC(Cl)=C(C=C4)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 636.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF. Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. Diabetes. 2002 Aug;51(8):2405-11. doi: 10.2337/diabetes.51.8.2405. PMID: 12145151. 2. Dubé N, Cheng A, Tremblay ML. The role of protein tyrosine phosphatase 1B in Ras signaling. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1834-9. doi: 10.1073/pnas.0304242101. Epub 2004 Feb 6. PMID: 14766979; PMCID: PMC357013.