GNE-9278 is a potent and selective NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Mutation of a single residue near the Lurcher motif on GluN1 M3 can convert GNE-9278 modulation from positive to negative, and replacing three AMPAR pre-M1 residues with corresponding NMDAR residues can confer GNE-9278 sensitivity to AMPARs. Modulation by GNE-9278 is state-dependent and significantly alters extracellular domain pharmacology.
MedKoo Cat#: 555177
Name: GNE-9278
CAS#: 901230-11-3 (free base)
Chemical Formula: C21H27N5O3S
Exact Mass: 429.1835
Molecular Weight: 429.54
Elemental Analysis: C, 58.72; H, 6.34; N, 16.30; O, 11.17; S, 7.46
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.0 | 100.00 |
The following data is based on the product molecular weight 429.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
