Synonym
Y 25510; Y-25510; Y25510.
IUPAC/Chemical Name
1H-Pyrazolo(3,4-b)pyridine-1-acetic acid, 3-(4-(2-(dimethylamino)-1-methylethoxy)phenyl)-, (+-)-
InChi Key
DYLPVOLNSXUKPG-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22N4O3/c1-13(11-22(2)3)26-15-8-6-14(7-9-15)18-16-5-4-10-20-19(16)23(21-18)12-17(24)25/h4-10,13H,11-12H2,1-3H3,(H,24,25)
SMILES Code
CC(CN(C)C)Oc1ccc(cc1)c2c3cccnc3n(n2)CC(=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
354.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Azuma J, Ogura M, Yamamoto I, Hisadome M, Fukuda T, Ikeda Y, Mori H, Oka T, Asano S. The effect of Y-25510 injection on the serum levels of some cytokines in healthy adult volunteers. Eur J Clin Pharmacol. 1998 Feb;53(6):411-9. PubMed PMID: 9551699.
2: Kusuhara H, Komatsu H, Hisadome M, Ikeda Y. (+/-)-3-[4-(2-dimethylamino-1-methylethoxy)-phenyl]-1H-pyrazolo[3,4- B]pyridine-1-acetic acid (Y-25510) stimulates production of IL-1 beta and IL-6 at the level of messenger RNA expression in cultured human monocytes. Int J Immunopharmacol. 1996 Dec;18(12):719-28. PubMed PMID: 9172015.
3: Hisadome M, Fukuda T, Matsuyuki H, Ikeda Y, Nomoto K. Enhancement of in vivo production of IL-1 alpha and IL-6 in mice by Y-25510, a 1H-pyrazolo[3,4-b]pyridine-1 acetic acid derivative. Int J Immunopharmacol. 1996 Jun-Jul;18(6-7):379-84. PubMed PMID: 9024939.
4: Hisadome M, Fukuda T, Terasawa M, Oe T, Takahata H, Goto K, Tsuru S, Nomoto K. Enhancement of host defense by Y-25510, (+-)-3-[4-(2-dimethylamino-1-methylethoxy)phenyl]-1H-pyrazolo[3,4 -b] pyridine-1-acetic acid, a novel synthetic compound. A comparison with recombinant human granulocyte colony-stimulating factor in 5-fluorouracil-treated mice. Int J Immunopharmacol. 1992 Oct;14(7):1195-201. PubMed PMID: 1280628.