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MedKoo Cat#: 596595 | Name: L 651896

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 651896 is a 5-lipoxygenase inhibitor.

Chemical Structure

L 651896
L 651896
CAS#99134-29-9

Theoretical Analysis

MedKoo Cat#: 596595

Name: L 651896

CAS#: 99134-29-9

Chemical Formula: C18H18O3

Exact Mass: 282.1256

Molecular Weight: 282.33

Elemental Analysis: C, 76.57; H, 6.43; O, 17.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
L 651896; L-651896; L651896;
IUPAC/Chemical Name
(E)-6-(3-(2-(hydroxymethyl)phenyl)allyl)-2,3-dihydrobenzofuran-5-ol
InChi Key
RRKABGWFFMSVQH-ZZXKWVIFSA-N
InChi Code
InChI=1S/C18H18O3/c19-12-16-5-2-1-4-13(16)6-3-7-14-11-18-15(8-9-21-18)10-17(14)20/h1-6,10-11,19-20H,7-9,12H2/b6-3+
SMILES Code
OC1=C(C/C=C/C2=CC=CC=C2CO)C=C(OCC3)C3=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 282.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Millichamp NJ, Dziezyc J, Rohde BH, Chiou GC, Smith WB. Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs. Am J Vet Res. 1991 Aug;52(8):1279-84. PubMed PMID: 1656823. 2: Hammond ML, Zambias RA, Chang MN, Jensen NP, McDonald J, Thompson K, Boulton DA, Kopka IE, Hand KM, Opas EE, et al. Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent. J Med Chem. 1990 Mar;33(3):908-18. PubMed PMID: 2308140. 3: Dembinska-Kiec A, Novak P, Peskar BM, Peskar BA. Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. Prog Clin Biol Res. 1989;301:487-91. PubMed PMID: 2798459. 4: Dembinska-Kiec A, Peskar BA, Muller MK, Peskar BM. The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. Prostaglandins. 1989 Jan;37(1):69-91. PubMed PMID: 2717778. 5: Jones TR, Charette L, Denis D. Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor. Can J Physiol Pharmacol. 1988 Jun;66(6):762-8. PubMed PMID: 2844372. 6: Matuszewski BK, Constanzer ML, Bayne WF. Determination of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol in plasma using liquid chromatography with electrochemical detection. J Chromatogr. 1988 Apr 29;426(2):295-304. PubMed PMID: 3392142. 7: Bonney RJ, Davies P, Dougherty H, Egan RW, Gale PH, Chang M, Hammond M, Jensen N, MacDonald J, Thompson K, et al. Biochemical and biological activities of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896), a novel topical anti-inflammatory agent. Biochem Pharmacol. 1987 Nov 15;36(22):3885-91. PubMed PMID: 3120729. 8: Garceau D, Ford-Hutchinson AW, Charleson S. 5-Lipoxygenase inhibitors and allergic conjunctivitis reactions in the guinea-pig. Eur J Pharmacol. 1987 Nov 3;143(1):1-7. PubMed PMID: 2826183. 9: Chan CC, Dubois L, Young V. Effects of two novel inhibitors of 5-lipoxygenase, L-651,392 and L-651,896, in a guinea-pig model of epidermal hyperproliferation. Eur J Pharmacol. 1987 Jul 2;139(1):11-8. PubMed PMID: 2820754.