D714 | CAS# 63906-31-0 | influence polymerase activity

MedKoo Cat#: 581091 | Name: D714

Description:

WARNING: This product is for research use only, not for human or veterinary use.

D714 is a weakly conserved palm-subdomain residue (located distant from the catalytic center), when replaced with alanine, impairs the replicative functions of the enzyme both in vivo and in vitro.

Chemical Structure

D714

CAS#63906-31-0

Theoretical Analysis

MedKoo Cat#: 581091

Name: D714

CAS#: 63906-31-0

Chemical Formula: C21H28ClN3OS2

Exact Mass: 437.1362

Molecular Weight: 438.04

Elemental Analysis: C, 57.58; H, 6.44; Cl, 8.09; N, 9.59; O, 3.65; S, 14.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

D714; D 714; D-714;

IUPAC/Chemical Name

10H-Pyrido(3,2-b)(1,4)benzothiazine-10-carbothioic acid, S-((2-diisopropylamino-1-methyl)ethyl) ester, hydrochloride

InChi Key

JEBZXFIOPYWIRH-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H27N3OS2.ClH/c1-14(2)23(15(3)4)13-16(5)26-21(25)24-17-9-6-7-10-18(17)27-19-11-8-12-22-20(19)24;/h6-12,14-16H,13H2,1-5H3;1H

SMILES Code

O=C(N1C2=NC=CC=C2SC3=CC=CC=C13)SC(C)CN(C(C)C)C(C)C.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 438.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jacewicz A, Trzemecka A, Guja KE, Plochocka D, Yakubovskaya E, Bebenek A, Garcia-Diaz M. A remote palm domain residue of RB69 DNA polymerase is critical for enzyme activity and influences the conformation of the active site. PLoS One. 2013 Oct 7;8(10):e76700. doi: 10.1371/journal.pone.0076700. eCollection 2013. PubMed PMID: 24116139; PubMed Central PMCID: PMC3792054. 2: Tanaka A, Katsuno T, Ozaki T, Sakata F, Kato N, Suzuki Y, Kosugi T, Kato S, Tsuboi N, Sato W, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S. The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. Acta Cardiol. 2015 Apr;70(2):217-23. PubMed PMID: 26148383. 3: Wang K, Sitsel O, Meloni G, Autzen HE, Andersson M, Klymchuk T, Nielsen AM, Rees DC, Nissen P, Gourdon P. Structure and mechanism of Zn2+-transporting P-type ATPases. Nature. 2014 Oct 23;514(7523):518-22. doi: 10.1038/nature13618. Epub 2014 Aug 17. PubMed PMID: 25132545; PubMed Central PMCID: PMC4259247. 4: Poelchau M, Childers C, Moore G, Tsavatapalli V, Evans J, Lee CY, Lin H, Lin JW, Hackett K. The i5k Workspace@NAL--enabling genomic data access, visualization and curation of arthropod genomes. Nucleic Acids Res. 2015 Jan;43(Database issue):D714-9. doi: 10.1093/nar/gku983. Epub 2014 Oct 20. PubMed PMID: 25332403; PubMed Central PMCID: PMC4384035. 5: Lloyd SA, Lang CH, Zhang Y, Paul EM, Laufenberg LJ, Lewis GS, Donahue HJ. Interdependence of muscle atrophy and bone loss induced by mechanical unloading. J Bone Miner Res. 2014;29(5):1118-30. doi: 10.1002/jbmr.2113. PubMed PMID: 24127218; PubMed Central PMCID: PMC4074925. 6: Zarocostas J. Donor countries have responsibility to root out corruption in aid flows. BMJ. 2011 Feb 2;342:d714. doi: 10.1136/bmj.d714. PubMed PMID: 21289010. 7: Walschus U, Hoene A, Patrzyk M, Finke B, Polak M, Lucke S, Nebe B, Schroeder K, Podbielski A, Wilhelm L, Schlosser M. Serum profile of pro- and anti-inflammatory cytokines in rats following implantation of low-temperature plasma-modified titanium plates. J Mater Sci Mater Med. 2012 May;23(5):1299-307. doi: 10.1007/s10856-012-4600-z. Epub 2012 Mar 9. PubMed PMID: 22402792. 8: Lemon HM, Rodriguez-Sierra JF. Timing of breast cancer surgery during the luteal menstrual phase may improve prognosis. Nebr Med J. 1996 Mar;81(3):73-8. Corrected and republished in: Nebr Med J. 1996 Apr;81(4):110-5. PubMed PMID: 8907825. 9: Choi J, Cheong K, Jung K, Jeon J, Lee GW, Kang S, Kim S, Lee YW, Lee YH. CFGP 2.0: a versatile web-based platform for supporting comparative and evolutionary genomics of fungi and Oomycetes. Nucleic Acids Res. 2013 Jan;41(Database issue):D714-9. doi: 10.1093/nar/gks1163. Epub 2012 Nov 27. PubMed PMID: 23193288; PubMed Central PMCID: PMC3531191. 10: Kalli KR, Conover CA. The insulin-like growth factor/insulin system in epithelial ovarian cancer. Front Biosci. 2003 May 1;8:d714-22. Review. PubMed PMID: 12700030.