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MedKoo Cat#: 341056 | Name: Cargutocin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cargutocin is a biochemical.

Chemical Structure

Cargutocin
Cargutocin
CAS#33605-67-3

Theoretical Analysis

MedKoo Cat#: 341056

Name: Cargutocin

CAS#: 33605-67-3

Chemical Formula: C42H65N11O12

Exact Mass: 915.4814

Molecular Weight: 916.05

Elemental Analysis: C, 55.07; H, 7.15; N, 16.82; O, 20.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cargutocin; Y-5350; Y 5350; Y5350.
IUPAC/Chemical Name
1,6-Dicarbaoxytocin, 1-butanoic acid-7-glycine- (9CI)
InChi Key
YHKWDHMRGAMOKU-DACMYBEBSA-N
InChi Code
InChI=1S/C42H65N11O12/c1-5-23(4)36-42(65)51-27(15-16-31(43)55)39(62)52-30(19-32(44)56)40(63)50-26(37(60)47-21-35(59)49-28(17-22(2)3)38(61)46-20-33(45)57)9-7-6-8-10-34(58)48-29(41(64)53-36)18-24-11-13-25(54)14-12-24/h11-14,22-23,26-30,36,54H,5-10,15-21H2,1-4H3,(H2,43,55)(H2,44,56)(H2,45,57)(H,46,61)(H,47,60)(H,48,58)(H,49,59)(H,50,63)(H,51,65)(H,52,62)(H,53,64)/t23-,26-,27-,28-,29-,30-,36-/m0/s1
SMILES Code
CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCCC(=O)N[C@H](C(=O)N1)Cc2ccc(cc2)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 916.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Caceda SI, Ramos RR, Saborido CM. Pharmacoeconomic study comparing carbetocin with oxytocin for the prevention of hemorrhage following cesarean delivery in Lima, Peru. J Comp Eff Res. 2018 Jan;7(1):49-55. doi: 10.2217/cer-2017-0012. Epub 2017 Dec 21. PubMed PMID: 29264934. 2: Muggleton E. Oxytocin Study Raises Concerns About Carbetocin Use. Anesth Analg. 2017 Dec 11. doi: 10.1213/ANE.0000000000002710. [Epub ahead of print] PubMed PMID: 29239961. 3: Høgstedt UB, Østergaard J, Weiss T, Sjögren H, van de Weert M. Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin. J Pharm Sci. 2018 Mar;107(3):838-847. doi: 10.1016/j.xphs.2017.11.008. Epub 2017 Nov 21. PubMed PMID: 29162423. 4: Voon HY, Shafie AA, Bujang MA, Suharjono HN. Cost effectiveness analysis of carbetocin during cesarean section in a high volume maternity unit. J Obstet Gynaecol Res. 2018 Jan;44(1):109-116. doi: 10.1111/jog.13486. Epub 2017 Oct 13. PubMed PMID: 29027315. 5: Henríquez-Trujillo AR, Lucio-Romero RA, Bermúdez-Gallegos K. Analysis of the cost-effectiveness of carbetocin for the prevention of hemorrhage following cesarean delivery in Ecuador. J Comp Eff Res. 2017 Sep;6(6):529-536. doi: 10.2217/cer-2017-0004. Epub 2017 Sep 8. PubMed PMID: 28884585. 6: Taheripanah R, Shoman A, Karimzadeh MA, Zamaniyan M, Malih N. Efficacy of oxytocin versus carbetocin in prevention of postpartum hemorrhage after cesarean section under general anesthesia: a prospective randomized clinical trial. J Matern Fetal Neonatal Med. 2017 Jul 25:1-6. doi: 10.1080/14767058.2017.1355907. [Epub ahead of print] PubMed PMID: 28707488. 7: Lucas DN, Meshykhi LS, Nel MR. The role of carbetocin in the prevention and management of postpartum haemorrhage - In reply. Int J Obstet Anesth. 2017 Nov;32:91. doi: 10.1016/j.ijoa.2017.06.002. Epub 2017 Jun 20. PubMed PMID: 28689623. 8: Onwochei DN, Monks DT. The role of carbetocin in the prevention and management of postpartum haemorrhage. Int J Obstet Anesth. 2017 Nov;32:90-91. doi: 10.1016/j.ijoa.2017.06.001. Epub 2017 Jun 12. PubMed PMID: 28689622. 9: Seow KM, Chen KH, Wang PH, Lin YH, Hwang JL. Carbetocin versus oxytocin for prevention of postpartum hemorrhage in infertile women with twin pregnancy undergoing elective cesarean delivery. Taiwan J Obstet Gynecol. 2017 Jun;56(3):273-275. doi: 10.1016/j.tjog.2017.04.001. PubMed PMID: 28600032. 10: Pérez-Nieto OR, Castañón-González JA, Lima-Lucero IM, Delsol LAG. Near fatal bronchospasm and bradycardia after carbetocin administration. Med Intensiva. 2017 May 26. pii: S0210-5691(17)30148-1. doi: 10.1016/j.medin.2017.04.005. [Epub ahead of print] English, Spanish. PubMed PMID: 28554581. 11: Dell-Kuster S, Hoesli I, Lapaire O, Seeberger E, Steiner LA, Bucher HC, Girard T. Efficacy and safety of carbetocin given as an intravenous bolus compared with short infusion for Caesarean section - double-blind, double-dummy, randomized controlled non-inferiority trial. Br J Anaesth. 2017 May 1;118(5):772-780. doi: 10.1093/bja/aex034. PubMed PMID: 28498927. 12: Karpenko IA, Niko Y, Yakubovskyi VP, Gerasov AO, Bonnet D, Kovtun YP, Klymchenko AS. Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions. J Mater Chem C Mater. 2016 Apr 14;4(14):3002-3009. doi: 10.1039/C5TC03411F. Epub 2015 Dec 7. PubMed PMID: 28491320; PubMed Central PMCID: PMC5421572. 13: Salinas BT, Camaiora AK, Marcos EA, Gilsanz F. Chest Pain During Cesarean Delivery in Relation to Anomalous Right Coronary Artery: A Case Report. A A Case Rep. 2017 Aug 15;9(4):119-122. doi: 10.1213/XAA.0000000000000543. PubMed PMID: 28448321. 14: Luni Y, Borakati A, Matah A, Skeats K, Eedarapalli P. A prospective cohort study evaluating the cost-effectiveness of carbetocin for prevention of postpartum haemorrhage in caesarean sections. J Obstet Gynaecol. 2017 Jul;37(5):601-604. doi: 10.1080/01443615.2017.1284188. Epub 2017 Mar 20. PubMed PMID: 28317421. 15: van der Nelson HA, Draycott T, Siassakos D, Yau CWH, Hatswell AJ. Carbetocin versus oxytocin for prevention of post-partum haemorrhage at caesarean section in the United Kingdom: An economic impact analysis. Eur J Obstet Gynecol Reprod Biol. 2017 Mar;210:286-291. doi: 10.1016/j.ejogrb.2017.01.004. Epub 2017 Jan 3. PubMed PMID: 28088109. 16: Chen CY, Su YN, Lin TH, Chang Y, Horng HC, Wang PH, Yeh CC, Chang WH, Huang HY. Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan. Taiwan J Obstet Gynecol. 2016 Dec;55(6):804-809. doi: 10.1016/j.tjog.2016.07.009. PubMed PMID: 28040124. 17: Nucci B, Aya A, Aubry E, Ripart J. Carbetocin for prevention of postcesarean hemorrhage in women with severe preeclampsia: a before-after cohort comparison with oxytocin. J Clin Anesth. 2016 Dec;35:321-325. doi: 10.1016/j.jclinane.2016.08.017. Epub 2016 Oct 12. PubMed PMID: 27871550. 18: Carrillo-Gaucín S, Torres-Gómez LG. [Carbetocin and oxytocin: Prevention of postpartum hemorrhage in patients with risk factors for uterine atony]. Rev Med Inst Mex Seguro Soc. 2016;54 Suppl 3:S284-S290. Spanish. PubMed PMID: 27855051. 19: Meshykhi LS, Nel MR, Lucas DN. The role of carbetocin in the prevention and management of postpartum haemorrhage. Int J Obstet Anesth. 2016 Dec;28:61-69. doi: 10.1016/j.ijoa.2016.10.003. Epub 2016 Oct 18. Review. PubMed PMID: 27816269. 20: Jardine JE, Law P, Hogg M, Murphy D, Khan KS; C-SAFETY. Haemorrhage at caesarean section: a framework for prevention and research. Curr Opin Obstet Gynecol. 2016 Dec;28(6):492-498. Review. PubMed PMID: 27787286.

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RC 121

RC 121