MedKoo Cat#: 525749 | Name: BT173
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.

Chemical Structure

BT173
BT173
CAS#2232180-74-2

Theoretical Analysis

MedKoo Cat#: 525749

Name: BT173

CAS#: 2232180-74-2

Chemical Formula: C18H12BrN3O2

Exact Mass: 381.0113

Molecular Weight: 382.22

Elemental Analysis: C, 56.56; H, 3.16; Br, 20.91; N, 10.99; O, 8.37

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
1g USD 4,250.00 2 Weeks
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Related CAS #
No Data
Synonym
BT173; BT-173; BT 173;
IUPAC/Chemical Name
3-[3-(4-Bromo-phenyl)-[1,2,4]oxadiazol-5-yl]-7-methoxy-quinoline
InChi Key
IZEKVHBNUXXZFE-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H12BrN3O2/c1-23-15-7-4-12-8-13(10-20-16(12)9-15)18-21-17(22-24-18)11-2-5-14(19)6-3-11/h2-10H,1H3
SMILES Code
COC1=CC=C2C=C(C3=NC(C4=CC=C(Br)C=C4)=NO3)C=NC2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu R, Das B, Xiao W, Li Z, Li H, Lee K, He JC. A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-β1/Smad3 Pathway. J Am Soc Nephrol. 2017 Feb 20. pii: ASN.2016080841. doi: 10.1681/ASN.2016080841. [Epub ahead of print] PubMed PMID: 28220029.