Acerinol is a an active ingredient from traditional Chinese medicinal herbs that could be used as a cancer multidrug resistance reversal agent. Specifically, acerinol has been implicated in reversing resistance to the drugs that cause overexpression of the ABCB1 family of ATP-binding cassettes. Acerinol could increase the chemosensitivity of ABCB1-overexpressing HepG2/ADM and MCF-7/ADR cells to chemotherapeutic drugs, doxorubicin, vincristine and paclitaxel. Acerinol can significantly stimulate the activity of ABCB1 ATPase without affecting the expression of ABCB1 on neither mRNA nor protein level. Acerinol from C. acerina significantly enhances the cytotoxicity of chemotherapeutic drugs by modulating the function of ABCB1.
MedKoo Cat#: 571505
Name: Acerinol
CAS#: 19902-53-5
Chemical Formula: C30H46O5
Exact Mass: 486.3345
Molecular Weight: 486.69
Elemental Analysis: C, 74.04; H, 9.53; O, 16.44
The following data is based on the product molecular weight 486.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
