MedKoo Cat#: 562105 | Name: SA-16

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SA-16 is a potent PDK1 and Aurora kinase A dual inhibitor.

Chemical Structure

SA-16
SA-16
CAS#1919884-11-9

Theoretical Analysis

MedKoo Cat#: 562105

Name: SA-16

CAS#: 1919884-11-9

Chemical Formula: C33H24F2N6O4

Exact Mass: 606.1827

Molecular Weight: 606.58

Elemental Analysis: C, 65.34; H, 3.99; F, 6.26; N, 13.85; O, 10.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SA-16; SA 16; SA16;
IUPAC/Chemical Name
(R,Z)-N-(2-((3-((1H-Imidazol-5-yl)methylene)-2-oxoindolin-5-yl)amino)-2-oxo-1-phenylethyl)-1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
InChi Key
XCPMMIISBZJPHR-OXTLUBNBSA-N
InChi Code
InChI=1S/C33H24F2N6O4/c34-26-10-8-19(13-27(26)35)17-41-12-4-7-23(33(41)45)30(42)40-29(20-5-2-1-3-6-20)32(44)38-21-9-11-28-24(14-21)25(31(43)39-28)15-22-16-36-18-37-22/h1-16,18,29H,17H2,(H,36,37)(H,38,44)(H,39,43)(H,40,42)/b25-15-/t29-/m1/s1
SMILES Code
O=C(C1=CC=CN(CC2=CC=C(F)C(F)=C2)C1=O)N[C@H](C3=CC=CC=C3)C(NC4=CC5=C(NC(/C5=C\C6=CN=CN6)=O)C=C4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 606.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Daniele S, Sestito S, Pietrobono D, Giacomelli C, Chiellini G, Di Maio D, Marinelli L, Novellino E, Martini C, Rapposelli S. Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114. doi: 10.1021/acschemneuro.6b00251. Epub 2016 Nov 10. PubMed PMID: 27797168. 2: Giraud K, Pontin M, Sharples LD, Fletcher P, Dalgleish T, Eden A, Jenkins DP, Vuylsteke A. Use of a Structured Mirrors Intervention Does Not Reduce Delirium Incidence But May Improve Factual Memory Encoding in Cardiac Surgical ICU Patients Aged Over 70 Years: A Pilot Time-Cluster Randomized Controlled Trial. Front Aging Neurosci. 2016 Sep 28;8:228. eCollection 2016. PubMed PMID: 27733826; PubMed Central PMCID: PMC5039170. 3: Dabul AN, Kos VN, Gilmore MS, Camargo IL. Draft Genome Sequence of Methicillin-Resistant Staphylococcus aureus Strain SA16, Representative of an Endemic Clone from a Brazilian Hospital. Genome Announc. 2013 Sep 19;1(5). pii: e00754-13. doi: 10.1128/genomeA.00754-13. PubMed PMID: 24051324; PubMed Central PMCID: PMC3778207. 4: Asiegbu FO, Abu S, Stenlid J, Johansson M. Sequence polymorphism and molecular characterization of laccase genes of the conifer pathogen Heterobasidion annosum. Mycol Res. 2004 Feb;108(Pt 2):136-48. PubMed PMID: 15119350.