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MedKoo Cat#: 341023 | Name: Z-10-Hydroxyamitriptyline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z-10-Hydroxyamitriptyline

Chemical Structure

Z-10-Hydroxyamitriptyline
Z-10-Hydroxyamitriptyline
CAS#72402-20-1

Theoretical Analysis

MedKoo Cat#: 341023

Name: Z-10-Hydroxyamitriptyline

CAS#: 72402-20-1

Chemical Formula: C20H23NO

Exact Mass: 293.1780

Molecular Weight: 293.41

Elemental Analysis: C, 81.87; H, 7.90; N, 4.77; O, 5.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Z-10-Hydroxyamitriptyline
IUPAC/Chemical Name
5H-Dibenzo(a,d)cyclohepten-10-ol, 5-(3-(dimethylamino)propylidene)-10,11-dihydro-, (Z)-
InChi Key
GHWBJXOKAFHZAI-ATVHPVEESA-N
InChi Code
InChI=1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12-
SMILES Code
CN(C)CC\C=C/1\c2ccccc2CC(O)c3ccccc13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 293.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shimoda K, Yasuda S, Morita S, Shibasaki M, Someya T, Bertilsson L, Takahashi S. Significance of monitoring plasma levels of amitriptyline, and its hydroxylated and desmethylated metabolites in prediction of the clinical outcome of depressive state. Psychiatry Clin Neurosci. 1997 Feb;51(1):35-41. PubMed PMID: 9076859. 2: Ulrich S, Isensee T, Pester U. Simultaneous determination of amitriptyline, nortriptyline and four hydroxylated metabolites in serum by capillary gas-liquid chromatography with nitrogen-phosphorus-selective detection. J Chromatogr B Biomed Appl. 1996 Oct 11;685(1):81-9. PubMed PMID: 8930756. 3: Breyer-Pfaff U, Becher B, Nusser E, Nill K, Baier-Weber B, Zaunbrecher D, Wachsmuth H, Prox A. Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine. Xenobiotica. 1990 Jul;20(7):727-38. PubMed PMID: 2238706. 4: Nusser E, Nill K, Breyer-Pfaff U. Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine. J Chromatogr. 1990 Jun 8;528(1):163-71. PubMed PMID: 2384550. 5: Edelbroek PM, Zitman FG, Schreuder JN, Rooymans HG, de Wolff FA. Amitriptyline metabolism in relation to antidepressive effect. Clin Pharmacol Ther. 1984 Apr;35(4):467-73. PubMed PMID: 6705444.