Synonym
Tyrostatin; N-Isovaleryl-tyrosyl-leucyl-tyrosinal;
IUPAC/Chemical Name
(2S)-2-((2S)-3-(4-hydroxyphenyl)-N-(1-(4-hydroxyphenyl)-3-oxopropan-2-yl)-2-(3-methylbutanamido)propanamido)-4-methylpentanamide
InChi Key
LOHCSDORPLNBQQ-DDZRMCBLSA-N
InChi Code
InChI=1S/C29H39N3O6/c1-18(2)13-26(28(30)37)32(22(17-33)15-20-5-9-23(34)10-6-20)29(38)25(31-27(36)14-19(3)4)16-21-7-11-24(35)12-8-21/h5-12,17-19,22,25-26,34-35H,13-16H2,1-4H3,(H2,30,37)(H,31,36)/t22?,25-,26-/m0/s1
SMILES Code
CC(C)C[C@@H](C(N)=O)N(C([C@H](CC1=CC=C(O)C=C1)NC(CC(C)C)=O)=O)C(C=O)CC2=CC=C(O)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
525.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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7: Ezaki J, Takeda-Ezaki M, Oda K, Kominami E. Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis. Biochem Biophys Res Commun. 2000 Feb 24;268(3):904-8. PubMed PMID: 10679303.
