MedKoo Cat#: 620117 | Name: Fmoc-Val-Ala-PAB
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fmoc-Val-Ala-PAB, also known as Fmoc-Val-Ala-PAB-OH, is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery.

Chemical Structure

Fmoc-Val-Ala-PAB
Fmoc-Val-Ala-PAB
CAS#1394238-91-5

Theoretical Analysis

MedKoo Cat#: 620117

Name: Fmoc-Val-Ala-PAB

CAS#: 1394238-91-5

Chemical Formula: C30H33N3O5

Exact Mass: 515.2420

Molecular Weight: 515.61

Elemental Analysis: C, 69.88; H, 6.45; N, 8.15; O, 15.51

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
200mg USD 750.00 2 Weeks
500mg USD 1,450.00 2 Weeks
1g USD 2,450.00 2 Weeks
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Synonym
Fmoc-Val-Ala-PAB; ACD linker; Fmoc-Val-Ala-PAB-OH
IUPAC/Chemical Name
(9H-fluoren-9-yl)methyl (S)-1-((S)-1-(4-(hydroxymethyl)phenylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate
InChi Key
PIEQFKSWCKVBTP-PPHZAIPVSA-N
InChi Code
InChI=1S/C30H33N3O5/c1-18(2)27(29(36)31-19(3)28(35)32-21-14-12-20(16-34)13-15-21)33-30(37)38-17-26-24-10-6-4-8-22(24)23-9-5-7-11-25(23)26/h4-15,18-19,26-27,34H,16-17H2,1-3H3,(H,31,36)(H,32,35)(H,33,37)/t19-,27-/m0/s1
SMILES Code
O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)N[C@@H](C(C)C)C(N[C@@H](C)C(NC4=CC=C(CO)C=C4)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 515.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Beck A, Goetsch L, Dumontet C, Corvaïa N. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. doi: 10.1038/nrd.2016.268. Epub 2017 Mar 17. PMID: 28303026.