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MedKoo Cat#: 584302 | Name: Sedecamycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sedecamycin is a 17-membered macrolide antibiotic used for treating swine dysentery.

Chemical Structure

Sedecamycin
Sedecamycin
CAS#23477-98-7

Theoretical Analysis

MedKoo Cat#: 584302

Name: Sedecamycin

CAS#: 23477-98-7

Chemical Formula: C27H35NO8

Exact Mass: 501.2363

Molecular Weight: 501.58

Elemental Analysis: C, 64.66; H, 7.03; N, 2.79; O, 25.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Sedecamycin; T-2636; T-2636A; Ro 23-0731/000; NSC 145117.
IUPAC/Chemical Name
Propanamide, N-(13-(acetyloxy)-7-hydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo(13.2.2)nonadeca-3,5,9,11-tetraen-2-yl)-2-oxo-, (1S-(1R*,2S*,3E,5E,7R*,9E,11E,13R*,15S*,19S*))-
InChi Key
LSNBAGMWJRMBEO-VGBMZARNSA-N
InChi Code
InChI=1S/C27H35NO8/c1-15-7-10-20(31)11-8-16(2)13-23(28-25(33)18(4)29)27(6)24(32)17(3)22(36-26(27)34)14-21(12-9-15)35-19(5)30/h7-9,11-13,17,20-23,31H,10,14H2,1-6H3,(H,28,33)/b11-8+,12-9+,15-7+,16-13+/t17-,20+,21-,22-,23-,27+/m1/s1
SMILES Code
CC(C(N[C@H](/C=C(C)/C=C/[C@@H](O)C/C=C(C)/C=C/[C@@H](OC(C)=O)C[C@@]1([H])O2)[C@](C([C@@H]1C)=O)(C)C2=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 501.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hayashi T, Okada J, Kondo S, Yamazaki T. Role of intestinal excretion in the effect of subcutaneously administered sedecamycin on cecal infection caused by Treponema hyodysenteriae in mice. Antimicrob Agents Chemother. 1991 Aug;35(8):1601-4. PubMed PMID: 1929332; PubMed Central PMCID: PMC245226. 2: Hayashi T, Suenaga I, Narukawa N, Yamazaki T. In vitro and in vivo activities of sedecamycin against Treponema hyodysenteriae. Antimicrob Agents Chemother. 1988 Apr;32(4):458-61. PubMed PMID: 3377458; PubMed Central PMCID: PMC172201. 3: Molnár L. Sensitivity of strains of Serpulina hyodysenteriae isolated in Hungary to chemotherapeutic drugs. Vet Rec. 1996 Feb 17;138(7):158-60. PubMed PMID: 8677605. 4: Okada J, Kondo S. Liquid chromatographic method for determining the macrolide antibiotic sedecamycin and its major metabolites in swine plasma and tissues. J Assoc Off Anal Chem. 1987 Sep-Oct;70(5):818-24. PubMed PMID: 3680117. 5: Ueda Y, Narukawa N. Effect of terdecamycin on experimentally induced swine dysentery in pigs. J Vet Med Sci. 1995 Feb;57(1):173-6. PubMed PMID: 7756416. 6: Okada J, Kondo S. Incorporation of radioactivity into fatty acids in pigs after successive administration of 14C-sedecamycin. Chem Pharm Bull (Tokyo). 1987 Nov;35(11):4664-7. PubMed PMID: 3442902. 7: Yatsukawa Y, Fujita K, Nakamura M, Watai M, Murayama M, Maitani T. [Simultaneous determination of sedecamycin and terdecamycin in livestock products by LC/MS]. Shokuhin Eiseigaku Zasshi. 2008 Jun;49(3):239-43. PubMed PMID: 18633209.