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MedKoo Cat#: 463110 | Name: Denudatine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Denudatine is an alkaloid that has been found in A. jinyangense and has antiarrhythmic activity. In vivo, denudatine prevents aconitine-induced arrhythmias in rats and increases survival in a rat model of calcium chloride-induced arrhythmias.

Chemical Structure

Denudatine
Denudatine
CAS#26166-37-0

Theoretical Analysis

MedKoo Cat#: 463110

Name: Denudatine

CAS#: 26166-37-0

Chemical Formula: C22H33NO2

Exact Mass: 343.2511

Molecular Weight: 343.51

Elemental Analysis: C, 76.92; H, 9.68; N, 4.08; O, 9.31

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 850.00 2 Weeks
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Related CAS #
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Synonym
Denudatine;
IUPAC/Chemical Name
(3R,6aS,6bS,7S,8R,10R,10aS,11R,11aR,13R)-1-ethyl-3-methyl-9-methylenedodecahydro-8H-3,6a,11-(epiethane[1,1,2]triyl)-8,10a-ethanoindeno[2,1-b]azocine-7,10-diol
InChi Key
OVXLNQAYPUEDSI-ZAWREGRRSA-N
InChi Code
InChI=1S/C22H33NO2/c1-4-23-11-20(3)7-5-8-22-15(20)10-14(18(22)23)21-9-6-13(12(2)19(21)25)16(24)17(21)22/h13-19,24-25H,2,4-11H2,1,3H3/t13-,14+,15-,16+,17-,18-,19-,20+,21+,22+/m1/s1
SMILES Code
O[C@@H]1[C@]2([C@]34[C@@H]5C[C@H]([C@@]2([C@@H]6O)CC[C@@H]1C6=C)[C@@]3([H])N(CC)C[C@]5(C)CCC4)[H]
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Denudatine is primarily isolated from plants of the genera Aconitum and Delphinium, and it has effects on action potential of ventricular fibers and inhibits arrhythmogenic action of aconitine.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 343.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
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