Fropofol | CAS#87591-05-7 | potent ligand

MedKoo Cat#: 527754 | Name: Fropofol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fropofol is a potent ligand for a protein site governed largely by van der Waals interactions, producing excitatory activity in tadpoles and mice; also antagonizing propofol-induced hypnosis.

Chemical Structure

Fropofol

CAS#87591-05-7

Theoretical Analysis

MedKoo Cat#: 527754

Name: Fropofol

CAS#: 87591-05-7

Chemical Formula: C12H17F

Exact Mass: 180.1314

Molecular Weight: 180.27

Elemental Analysis: C, 79.95; H, 9.51; F, 10.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Fropofol

IUPAC/Chemical Name

2-Fluoro-1,3-diisopropyl-benzene

InChi Key

WAWGGRDKKRRDOY-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H17F/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9H,1-4H3

SMILES Code

CC(C1=C(F)C(C(C)C)=CC=C1)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 180.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Optimum end-tidal concentration of sevoflurane to facilitate supraglottic airway device insertion with propofol at induction allowing spontaneous respiration in obese patients: A prospective observational study. Medicine (Baltimore). 2017 Nov;96(47):e8902. doi: 10.1097/MD.0000000000008902. PubMed PMID: 29382022. 4: Schmitz A, Weiss M, Kellenberger C, O Gorman Tuura R, Klaghofer R, Scheer I, Makki M, Sabandal C, Buehler PK. Sedation for magnetic resonance imaging using propofol with or without ketamine at induction in pediatrics-A prospective randomized double-blinded study. Paediatr Anaesth. 2018 Jan 27. doi: 10.1111/pan.13315. [Epub ahead of print] PubMed PMID: 29377404. 5: Shang Z, Feng H, Cui L, Wang W, Fu H. Propofol promotes apoptosis and suppresses the HOTAIR-mediated mTOR/p70S6K signaling pathway in melanoma cells. Oncol Lett. 2018 Jan;15(1):630-634. doi: 10.3892/ol.2017.7297. Epub 2017 Oct 31. PubMed PMID: 29375720; PubMed Central PMCID: PMC5766068. 6: Fassbender P, Bürgener S, Haddad A, Silvanus MT, Peters J. Perioperative incidence of airway obstructive and hypoxemic events in patients with confirmed or suspected sleep apnea - a prospective, randomized pilot study comparing propofol/remifentanil and sevoflurane/remifentanil anesthesia. BMC Anesthesiol. 2018 Jan 27;18(1):14. doi: 10.1186/s12871-018-0477-9. PubMed PMID: 29374469. 7: Friedberg BL. Opioid free anesthesia with BIS/EMG monitored propofol-ketamine. Rev Esp Anestesiol Reanim. 2018 Jan 19. pii: S0034-9356(17)30270-0. doi: 10.1016/j.redar.2017.11.011. [Epub ahead of print] English, Spanish. PubMed PMID: 29370902. 8: Wang B, Lv K, Liu H, Su Y, Wang H, Wang S, Bao S, Zhou WH, Lian QQ. Contribution of the α5 GABAA receptor to the discriminative stimulus effects of propofol in rat. Neuroreport. 2018 Jan 24. doi: 10.1097/WNR.0000000000000959. 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Spinal anesthesia is safe in laparoscopic total extraperitoneal inguinal hernia repair. A retrospective clinical trial. Wideochir Inne Tech Maloinwazyjne. 2017 Dec;12(4):417-427. doi: 10.5114/wiitm.2017.72325. Epub 2017 Dec 29. PubMed PMID: 29362658; PubMed Central PMCID: PMC5776491. 13: Raineri SM, Cortegiani A, Accurso G, Procaccianti C, Vitale F, Caruso S, Giarratano A, Gregoretti C. Efficacy and Safety of Using High-Flow Nasal Oxygenation in Patients Undergoing Rapid Sequence Intubation. Turk J Anaesthesiol Reanim. 2017 Dec;45(6):335-339. doi: 10.5152/TJAR.2017.47048. Epub 2017 Dec 1. PubMed PMID: 29359072; PubMed Central PMCID: PMC5772412. 14: Zhang B, Wang G, Liu X, Wang TL, Chi P. The Opioid-Sparing Effect of Perioperative Dexmedetomidine Combined with Oxycodone Infusion during Open Hepatectomy: A Randomized Controlled Trial. Front Pharmacol. 2018 Jan 4;8:940. doi: 10.3389/fphar.2017.00940. eCollection 2017. 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