GAP112-RBD | CAS#N/A | conjugate vaccine SARS-CoV-2

MedKoo Cat#: 130260 | Name: GAP112-RBD

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GAP112-RBD is an agent consisting of a TLR4 agonist conjugated to an antigen to form a vaccine for use against SARS-CoV-2.

Chemical Structure

GAP112-RBD

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130260

Name: GAP112-RBD

CAS#: N/A

Chemical Formula: C99H188N5O25P

Exact Mass: 1878.3331

Molecular Weight: 1879.58

Elemental Analysis: C, 63.26; H, 10.08; N, 3.73; O, 21.28; P, 1.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GAP112-RBD; GAP112 RBD; GAP 112-RBD; GAP-112-RBD

IUPAC/Chemical Name

(2R,3S,4R,5R,6R)-2-(18-(aminooxy)-3,17-dioxo-2,7,10,13-tetraoxa-4,16-diazaoctadecyl)-5-((R)-3-(dodecanoyloxy)tetradecanamido)-6-(2-((R)-3-(dodecanoyloxy)tetradecanamido)-3-hydroxy-2-(hydroxymethyl)propoxy)-3-(phosphonooxy)tetrahydro-2H-pyran-4-yl (R)-3-(dodecanoyloxy)tetradecanoate

InChi Key

FQODWBWDPOCONY-COHVJAALSA-N

InChi Code

InChI=1S/C99H188N5O25P/c1-7-13-19-25-31-37-43-49-55-61-83(124-90(110)64-58-52-46-40-34-28-22-16-10-4)75-87(107)103-94-96(128-93(113)77-85(63-57-51-45-39-33-27-21-15-9-3)126-92(112)66-60-54-48-42-36-30-24-18-12-6)95(129-130(115,116)117)86(78-121-98(114)102-68-70-119-72-74-120-73-71-118-69-67-101-89(109)79-123-100)127-97(94)122-82-99(80-105,81-106)104-88(108)76-84(62-56-50-44-38-32-26-20-14-8-2)125-91(111)65-59-53-47-41-35-29-23-17-11-5/h83-86,94-97,105-106H,7-82,100H2,1-6H3,(H,101,109)(H,102,114)(H,103,107)(H,104,108)(H2,115,116,117)/t83-,84-,85-,86-,94-,95-,96-,97-/m1/s1

SMILES Code

CCCCCCCCCCC[C@@H](OC(CCCCCCCCCCC)=O)CC(O[C@H]1[C@H](OP(O)(O)=O)[C@@H](COC(NCCOCCOCCOCCNC(CON)=O)=O)O[C@@H](OCC(CO)(NC(C[C@H](OC(CCCCCCCCCCC)=O)CCCCCCCCCCC)=O)CO)[C@@H]1NC(C[C@H](OC(CCCCCCCCCCC)=O)CCCCCCCCCCC)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,879.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Ding D, Wen Y, Liao CM, Yin XG, Zhang RY, Wang J, Zhou SH, Zhang ZM, Zou YK, Gao XF, Wei HW, Yang GF, Guo J. Self-Adjuvanting Protein Vaccine Conjugated with a Novel Synthetic TLR4 Agonist on Virus-Like Liposome Induces Potent Immunity against SARS-CoV-2. J Med Chem. 2023 Jan 26;66(2):1467-1483. doi: 10.1021/acs.jmedchem.2c01642. Epub 2023 Jan 10. PMID: 36625758; PMCID: PMC9844103.