SR8993 | CAS#1594121-16-0 | NOP agonist

MedKoo Cat#: 527699 | Name: SR8993

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR8993 is a highly selective, brain-penetrant nociceptin receptor (NOP) agonist.

Chemical Structure

SR8993

CAS#1594121-16-0

Theoretical Analysis

MedKoo Cat#: 527699

Name: SR8993

CAS#: 1594121-16-0

Chemical Formula: C25H37FN4

Exact Mass: 412.3002

Molecular Weight: 412.60

Elemental Analysis: C, 72.78; H, 9.04; F, 4.60; N, 13.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SR-8993; SR 8993; SR8993

IUPAC/Chemical Name

1-[1-(Cyclooctylmethyl)-4-piperidinyl]-5-fluoro-2-(3R)-3-pyrrolidinyl-1H-benzimidazole

InChi Key

UTSJKSDPSCCJFP-HXUWFJFHSA-N

InChi Code

InChI=1S/C25H37FN4/c26-21-8-9-24-23(16-21)28-25(20-10-13-27-17-20)30(24)22-11-14-29(15-12-22)18-19-6-4-2-1-3-5-7-19/h8-9,16,19-20,22,27H,1-7,10-15,17-18H2/t20-/m1/s1

SMILES Code

FC1=CC=C2C(N=C([C@H]3CNCC3)N2C4CCN(CC5CCCCCCC5)CC4)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 412.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Aziz AM, Brothers S, Sartor G, Holm L, Heilig M, Wahlestedt C, Thorsell A. The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models. Psychopharmacology (Berl). 2016 Oct;233(19-20):3553-63. doi: 10.1007/s00213-016-4385-8. Epub 2016 Aug 11. PubMed PMID: 27515665; PubMed Central PMCID: PMC5021736. 2: Sartor GC, Powell SK, Wiedner HJ, Wahlestedt C, Brothers SP. Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice. Brain Res. 2016 Feb 1;1632:34-41. doi: 10.1016/j.brainres.2015.11.044. Epub 2015 Dec 3. PubMed PMID: 26657743; PubMed Central PMCID: PMC4733396. 3: Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD. Sci Transl Med. 2013 Jun 5;5(188):188ra73. doi: 10.1126/scitranslmed.3005656. PubMed PMID: 23740899; PubMed Central PMCID: PMC3732318.