Pyrromecaine | CAS#19089-24-8 | anesthetic

MedKoo Cat#: 584301 | Name: Pyrromecaine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pyrromecaine is a local anesthetic used for surface anesthesia. Its marked antiarrhythmic activity has been established in various models of experimental cardiac arrhythmia in doses of 0.1-2.5 mg/kg. Pyromecaine has a wide spectrum of antiarrhythmic action, exerts a favourable effect on the intracardiac and systemic hemodynamics, on the contractility of the left ventricle and on the myocardial blood flow following the ligation of the coronary artery. Other positive properties of pyromecaine include its anesthetic activity and a relatively low toxicity.

Chemical Structure

Pyrromecaine HCl

CAS#19089-24-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 584301

Name: Pyrromecaine HCl

CAS#: 19089-24-8 (HCl)

Chemical Formula: C18H29ClN2O

Exact Mass: 324.1968

Molecular Weight: 324.89

Elemental Analysis: C, 66.54; H, 9.00; Cl, 10.91; N, 8.62; O, 4.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

19089-24-8 (HCl) 30103-44-7 (free base)

Synonym

Pyrromecaine; Bumecaine hydrochloride

IUPAC/Chemical Name

2-Pyrrolidinecarboxanilide, 1-butyl-2',4',6'-trimethyl-, monohydrochloride

InChi Key

NFEZGTHMTGKIBG-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H28N2O.ClH/c1-5-6-9-20-10-7-8-16(20)18(21)19-17-14(3)11-13(2)12-15(17)4;/h11-12,16H,5-10H2,1-4H3,(H,19,21);1H

SMILES Code

O=C(C1N(CCCC)CCC1)NC2=C(C)C=C(C)C=C2C.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 324.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kirichenko LL, Masenko VP, Nikitin AE, Narynskiĭ AK, Morozova LM. [Effect of anti-arrhythmia preparations on thrombocytic and vascular hemostasis]. Ter Arkh. 1986;58(6):70-2. Russian. PubMed PMID: 3764717. 2: Orlov VM, Ivashchuk AG, Iartsev SS, Pham TT. [Pyromecaine in the therapy of disorders of the heart rhythm]. Klin Med (Mosk). 1985 Jan;63(1):38-9. Russian. PubMed PMID: 3990186. 3: Samvelian VM, L'vov MV, Prianishnikova NT, Varosian MA, Bagramian IG. [Pyromecaine--a new anti-arrhythmia preparation improving myocardial blood supply]. Kardiologiia. 1985 Apr;25(4):85-9. Russian. PubMed PMID: 2410657. 4: Ushkalova EA, Petrov AD, Shcheglova NV. [Interaction of quinidine, lidocaine, tricaine and pyromecaine with heparin]. Farmakol Toksikol. 1989 Jul-Aug;52(4):43-5. Russian. PubMed PMID: 2806526. 5: Nazarov EI, Prianishnikova NT, Pavlova LI, Vongaĭ VG. [Effect of pyromecaine on ionic currents in electrically excitable membranes]. Biull Eksp Biol Med. 1985 Nov;100(11):574-6. Russian. PubMed PMID: 2415182. 6: Orlov VN, Kirilenko LL, Smirnov VV, Narynskiĭ AK. [Effect of pyromecaine on cellular hemostasis]. Sov Med. 1985;(6):61-6. Russian. PubMed PMID: 4059969. 7: Komar MD. [Local pyromecaine anesthesia of the urethra]. Urol Nefrol (Mosk). 1981 Jan-Feb;(1):58-9. Russian. PubMed PMID: 7210364. 8: Kirichenko LL, Smirnov VV, Narynskiĭ AK, Morozova LM. [Effect of lidocaine and pyromecaine on cellular hemostasis and microcirculation]. Sov Med. 1986;(3):84-6. Russian. PubMed PMID: 3520868. 9: Orlov VM, Ivashchuk AG, Iartsev SS, Meshcheriakova NK, Tkhu FT. [Comparative characteristics of the antiarrhythmic activity of lidocaine, trimecaine and pyromecaine]. Sov Med. 1984;(3):82-4. Russian. PubMed PMID: 6719244. 10: Smirnov VK, Orlov VN, Gorshkov VA, Piotrovskiĭ VK, Blagodatskikh SV. [Effectiveness of pyromecaine in cardiac rhythm disorders (intravenous administration schedules)]. Kardiologiia. 1985 Jul;25(7):112-4. Russian. PubMed PMID: 4057729. 11: Koriachkin VA, Safonov VL. [Clinical evaluation of pyromecaine for peridural anesthesia in general surgery]. Vestn Khir Im I I Grek. 1986 Mar;136(3):117-8. Russian. PubMed PMID: 3727285. 12: Piotrovskiĭ VK, Blagodatskikh SV, Metelitsa VI, Smirnov VK, Gorshkov VA. [Clinical pharmacokinetics of pyromecaine. Prolonged intravenous infusion and the relation between its antiarrhythmic effect and its concentration]. Farmakol Toksikol. 1985 Jul-Aug;48(4):83-6. Russian. PubMed PMID: 2412887. 13: Gortsakalian EL, Nesvetov VN, Smirnov VK. [Effect of piromecaine on central hemodynamics in myocardial infarction]. Sov Med. 1987;(7):76-8. Russian. PubMed PMID: 3686207. 14: Konobevtsev OF, Panikarovskiĭ VV, Grigor'ian AS, Kolesnik AG, Kondaurov VN. [Penetration of pyromecaine through the dentin into the dental pulp]. Stomatologiia (Mosk). 1982 Jul-Aug;61(4):11-2. Russian. PubMed PMID: 6957027. 15: Fomichev VA, Khromenkov IE, Khriachkov VV. [Prolonged peridural anesthesia with pyromecaine]. Vestn Khir Im I I Grek. 1983 Aug;131(8):88-9. Russian. PubMed PMID: 6649293. 16: Goldshteĭne GKh, Tsorin IB, Chichkanov GG. [Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct]. Biull Eksp Biol Med. 1986 Feb;101(2):177-9. Russian. PubMed PMID: 3947734. 17: Kaĭfadzhian MA, Dzhanpoladian EG. [The Ca2+ reactivity and the subunit composition of myocardial actomyosin during the pyromecaine and pyrroxan treatment of experimental ischemia]. Farmakol Toksikol. 1990 Jan-Feb;53(1):27-30. Russian. PubMed PMID: 1970309. 18: Konobevtsev OF, Ivanova LA, Kondaurov VN, Zidra SI, Lobzhanidze TA. [Pharmaceutical forms of the local anesthetic pyromecaine]. Anesteziol Reanimatol. 1986 May-Jun;(3):50-2. Russian. PubMed PMID: 3752610. 19: Konobevtsev OF, Kondaurov VN, Panikarovskiĭ VV, Kulikova VS, Grigor'ian AS. [Toxicological characteristics of a new collagen-based pyromecaine ointment]. Stomatologiia (Mosk). 1980 Sep-Oct;59(5):27-9. Russian. PubMed PMID: 6932748. 20: Buniatian AA, Seleznev MN, Iavorovskiĭ AG. [Comparative evaluation of the effect of pyromecaine and lidocaine on central hemodynamics and their efficacy in the prevention and treatment of heart rhythm disorders]. Anesteziol Reanimatol. 1986 Nov-Dec;(6):41-4. Russian. PubMed PMID: 3493714.