Synonym
Buquinolate; Bonaid TM; Buchinolatum; Bukhinolyat; Butoril; NSC 201116; NSC201116; NSC-201116
IUPAC/Chemical Name
3-Quinolinecarboxylic acid, 4-hydroxy-6,7-bis(2-methylpropoxy)-, ethyl ester
InChi Key
LVVXOXRUTDAKFE-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H27NO5/c1-6-24-20(23)15-9-21-16-8-18(26-11-13(4)5)17(25-10-12(2)3)7-14(16)19(15)22/h7-9,12-13H,6,10-11H2,1-5H3,(H,21,22)
SMILES Code
O=C(C1=C(O)C2=CC(OCC(C)C)=C(OCC(C)C)C=C2N=C1)OCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
361.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nakajima T, Hayashi H, Sasamoto T, Kanda M, Kusano T, Matsushima Y, Kanai S, Takeba K, Nagayama T. [Determination of nequinate and buquinolate in livestock products using liquid chromatography-tandem mass spectrometry]. Shokuhin Eiseigaku Zasshi. 2011;52(3):178-82. PubMed PMID: 21720123.
2: Herrett RJ, Williams CW, Klein GM, Heotis JP. The distribution of C14 in the chick following the administration of buquinolate-3-C14. Poult Sci. 1967 May;46(3):755-61. PubMed PMID: 6082025.
3: Edgar SA, Flanagan C. Coccidiostatic effects of buquinolate in poultry. Poult Sci. 1968 Jan;47(1):95-104. PubMed PMID: 5645319.
4: Engle AT, Humphrey RP, Johnson CA. Buquinolate, a new broad spectrum coccidiostat. Poult Sci. 1967 Jul;46(4):810-8. PubMed PMID: 6064475.
5: Leathem WD. Buquinolate and immunization to Eimeria acervulina. Poult Sci. 1973 Jul;52(4):1468-72. PubMed PMID: 4773337.
6: Kohls RE, Engle AT, Butters HE. Effects of continuous buquinolate medication of laying chickens. Avian Dis. 1972 Jul-Sep;16(4):907-14. PubMed PMID: 5079881.
7: Sadler CR, Day EJ, French JE. Efficacy of buquinolate against artificial coccidiosis infection in broiler chickens. Poult Sci. 1968 Nov;47(6):1917-21. PubMed PMID: 5752535.
8: McLoughlin DK. Efficacy of buquinolate against ten strains of Eimeria tenella and the development of a resistant strain. Avian Dis. 1970 Feb;14(1):126-30. PubMed PMID: 5434433.
9: Eckman MK, Kohls RE, Humphrey RP. Relationship of particle size to coccidiostatic efficacy of buquinolate. Avian Dis. 1969 May;13(2):297-308. PubMed PMID: 5816044.
10: Leathem WD, Kohls RE. Acquired immunity of buquinolate-medicated chickens to Eimeria tenella infection. Poult Sci. 1971 Sep;50(5):1492-5. PubMed PMID: 5094394.
11: Leathem WD, Engle AT. Effect of two levels of buquinolate on endogenous development and oocyst suppression of Eimeria tenella. Poult Sci. 1970 Jul;49(4):1109-13. PubMed PMID: 5485480.
12: Onawunmi OA, Todd AC. Suppression and control of experimentally induced procine coccidiosis with chlortetracycline combination, buquinolate, and lincomycin hydrochloride. Am J Vet Res. 1976 Jun;37(6):657-60. PubMed PMID: 937785.
13: Stephens JF, Barnett BD, Butters HE. Effect of buquinolate on growth and egg production of white leghorn pullets. Poult Sci. 1967 Jan;46(1):203-6. PubMed PMID: 6031869.
14: Eckman MK, Humphrey RP, Kohls RE. Efficacy of buquinolate in chickens inoculated with drug-sensitive and drug-tolerant coccidial species. Avian Dis. 1972 May-Jun;16(3):492-500. PubMed PMID: 5038648.
15: Chapman HD. Eimeria tenella in chickens: development of resistance to quinolone anticoccidial drugs. Parasitology. 1975 Aug;71(1):41-9. PubMed PMID: 1058450.
16: Canton JH, van Esch GJ. The short-term toxicity of some feed additives to different freshwater organisms. Bull Environ Contam Toxicol. 1976 Jun;15(6):720-5. PubMed PMID: 938765.
17: Matus JL, Boison JO. A multi-residue method for 17 anticoccidial drugs and ractopamine in animal tissues by liquid chromatography-tandem mass spectrometry and time-of-flight mass spectrometry. Drug Test Anal. 2016 May;8(5-6):465-76. doi: 10.1002/dta.2019. PubMed PMID: 27443201.
18: Mitrovic M, Schildknecht EG. Lasalocid: resistance and cross-resistance studies in Eimeria tenella-infected chicks. Poult Sci. 1975 May;54(3):750-6. PubMed PMID: 1153374.
19: Norton CC, Joyner LP. The development of drug-resistant strains of Eimeria maxima in the laboratory. Parasitology. 1975 Aug;71(1):153-65. PubMed PMID: 1058449.
20: Wang CC. Studies of the mitochondria from Eimeria tenella and inhibition of the electron transport by quinolone coccidiostats. Biochim Biophys Acta. 1975 Aug 11;396(2):210-9. PubMed PMID: 1171697.
