Synonym
PF-06815189; PF 06815189; PF06815189;
IUPAC/Chemical Name
7-(1,3-dimethyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)-5-(hydroxymethyl)-2-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
InChi Key
XLTUOMBYHVTYOT-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H17F3N6O2/c1-9-14(17-24-13(8-29)16-18(30)23-10(2)26-28(16)17)15(27(3)25-9)11-4-6-12(7-5-11)19(20,21)22/h4-7,29H,8H2,1-3H3,(H,23,26,30)
SMILES Code
O=C1NC(C)=NN2C1=C(CO)N=C2C3=C(C4=CC=C(C(F)(F)F)C=C4)N(C)N=C3C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
418.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189. Antonia F. Stepan*† , Tuan P. Tran‡ , Christopher J. Helal‡ , Maria S. Brown‡, Cheng Chang‡, Rebecca E. O’Connor‡, Michael De Vivo†, Shawn D. Doran‡, Ethan L. Fisher‡, Stephen Jenkinson§, David Karanian‡, Bethany L. Kormos†, Raman Sharma‡, Gregory S. Walker‡, Ann S. Wright‡, Edward X. Yang‡, Michael A. Brodney†, Travis T. Wager† , Patrick R. Verhoest†, and R. Scott Obach‡. ACS Med. Chem. Lett., Article ASAP DOI: 10.1021/acsmedchemlett.7b00343 Publication Date (Web): January 4, 2018 Copyright © 2018 American Chemical Society
