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MedKoo Cat#: 562864 | Name: SIRT1-A2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIRT1-A2 is a SIRT1 activator.

Chemical Structure

SIRT1-A2
SIRT1-A2
CAS#304448-98-4

Theoretical Analysis

MedKoo Cat#: 562864

Name: SIRT1-A2

CAS#: 304448-98-4

Chemical Formula: C30H19N3O8

Exact Mass: 549.1172

Molecular Weight: 549.49

Elemental Analysis: C, 65.57; H, 3.49; N, 7.65; O, 23.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
SIRT1-A2; SIRT1 A2; SIRT1A2; SIRT1-Activator-A2; SIRT1 Activator A2;
IUPAC/Chemical Name
3-[[4-[5-[[(3-Carboxyphenyl)amino]carbonyl]-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl]benzoyl]amino]-benzoic acid
InChi Key
FORJYIUWZMPOFL-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H19N3O8/c34-25(31-20-5-1-3-18(13-20)29(38)39)16-7-10-22(11-8-16)33-27(36)23-12-9-17(15-24(23)28(33)37)26(35)32-21-6-2-4-19(14-21)30(40)41/h1-15H,(H,31,34)(H,32,35)(H,38,39)(H,40,41)
SMILES Code
O=C(O)C1=CC=CC(NC(C2=CC=C(N(C(C3=C4C=CC(C(NC5=CC=CC(C(O)=O)=C5)=O)=C3)=O)C4=O)C=C2)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 549.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xiao P, Huang X, Huang L, Yang J, Li A, Shen K, Wedegaertner PB, Jiang X. G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. Exp Cell Res. 2017 Nov 15;360(2):273-280. doi: 10.1016/j.yexcr.2017.09.017. Epub 2017 Sep 11. PubMed PMID: 28912086; PubMed Central PMCID: PMC5944352. 2: Kuefner MS, Pham K, Redd JR, Stephenson EJ, Harvey I, Deng X, Bridges D, Boilard E, Elam MB, Park EA. Secretory phospholipase A(2) group IIA modulates insulin sensitivity and metabolism. J Lipid Res. 2017 Sep;58(9):1822-1833. doi: 10.1194/jlr.M076141. Epub 2017 Jun 29. PubMed PMID: 28663239; PubMed Central PMCID: PMC5580896. 3: Sun S, Zhang M, Yang Q, Shen Z, Chen J, Yu B, Wang H, Qu J, Pang D, Ren W, Ouyang H, Tang X. Resveratrol suppresses lipoprotein-associated phospholipase A(2) expression by reducing oxidative stress in macrophages and animal models. Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201601112. Epub 2017 Jul 20. PubMed PMID: 28608449. 4: Sobolesky PM, Halushka PV, Garrett-Mayer E, Smith MT, Moussa O. Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer. PLoS One. 2014 Sep 9;9(9):e107530. doi: 10.1371/journal.pone.0107530. eCollection 2014. PubMed PMID: 25202904; PubMed Central PMCID: PMC4159332. 5: Takizawa Y, Kosuge Y, Awaji H, Tamura E, Takai A, Yanai T, Yamamoto R, Kokame K, Miyata T, Nakata R, Inoue H. Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells. Br J Nutr. 2013 Dec;110(12):2150-5. doi: 10.1017/S0007114513001670. Epub 2013 Jun 11. PubMed PMID: 23750556. 6: Mitterberger MC, Zwerschke W. Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes. J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1356-76. doi: 10.1093/gerona/glt019. Epub 2013 Mar 22. PubMed PMID: 23525482. 7: Wu A, Ying Z, Gomez-Pinilla F. The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. J Neurotrauma. 2011 Oct;28(10):2113-22. doi: 10.1089/neu.2011.1872. Epub 2011 Oct 4. PubMed PMID: 21851229; PubMed Central PMCID: PMC3191367. 8: Borradaile NM, Pickering JG. Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase. Am J Physiol Cell Physiol. 2010 Jan;298(1):C66-74. doi: 10.1152/ajpcell.00357.2009. Epub 2009 Oct 21. PubMed PMID: 19846757.