IUPAC/Chemical Name
Guanidine, N-(3-(3,4-difluorophenyl)-3-(2-pyridinyl)propyl)-N'-(3-(1H-imidazol-4-yl)propyl)-
InChi Key
ZHUPJEZTXBUHGR-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24F2N6/c22-18-7-6-15(12-19(18)23)17(20-5-1-2-9-26-20)8-11-28-21(24)27-10-3-4-16-13-25-14-29-16/h1-2,5-7,9,12-14,17H,3-4,8,10-11H2,(H,25,29)(H3,24,27,28)
SMILES Code
N=C(NCCCC1=CNC=N1)NCCC(C2=CC=C(F)C(F)=C2)C3=NC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
398.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Lemos Legnazzi B, Shayo C, Monczor F, Martin ME, Fernandez N, Brodsky A, Baldi A, Davio C. Rapid desensitization and slow recovery of the cyclic AMP response mediated by histamine H(2) receptors in the U937 cell line. Biochem Pharmacol. 2000 Jul 15;60(2):159-66. PubMed PMID: 10825460.
6: Kleine-Tebbe J, Buschauer A, Friese A, Schunack W, Kunkel G. Modulation of IgE-mediated histamine release from human leukocytes by a new class of histamine H2-agonists. Agents Actions. 1992 Mar;35(3-4):185-91. PubMed PMID: 1382368.
7: Monczor F, Legnazzi BL, Rivera E, Davio C. Tiotidine, a classical H2-antagonist, presents characteristics of an inverse agonist in U937 cell line. Inflamm Res. 1998;47 Suppl 1:S42-3. PubMed PMID: 9561408.
