Synonym
Idrocilamide; Brolitene
IUPAC/Chemical Name
2-Propenamide, N-(2-hydroxyethyl)-3-phenyl-
InChi Key
OSCTXCOERRNGLW-VOTSOKGWSA-N
InChi Code
InChI=1S/C11H13NO2/c13-9-8-12-11(14)7-6-10-4-2-1-3-5-10/h1-7,13H,8-9H2,(H,12,14)/b7-6+
SMILES Code
O=C(NCCO)/C=C/C1=CC=CC=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
191.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lery N, Evreux JC, Schwam E, Laisne H. [Letter: Unusual neuropsychic effects due to idrocilamide]. Nouv Presse Med. 1976 Feb 28;5(9):583-4. French. PubMed PMID: 1264724.
2: Bannwarth B, Le Huec JC, Vinçon G, Labat L, Demotes-Mainard F, Rivaille F, Le Rebeller A. [Tissue and systemic diffusion of idrocilamide after cutaneous administration]. Rev Rhum Ed Fr. 1993 Dec;60(12):932-6. French. PubMed PMID: 8012322.
3: Mouzou A, Bouron A, Guillemain J, Guerrier D, Raymond G. Two sites of action for LCB29 (idrocilamide) in depressing mechanical tension of rat soleus muscle fibers? Can J Physiol Pharmacol. 1993 Dec;71(12):889-95. PubMed PMID: 8180884.
4: Lacroix C, Nouveau J, Hubscher P, Tardif D, Ray M, Goulle JP. [Influence of idrocilamide on the metabolism of theophylline]. Rev Pneumol Clin. 1986;42(3):164-6. French. PubMed PMID: 3775181.
5: Trêves R, Maheu E, Dreiser RL. Therapeutic trials in digital osteoarthritis. A critical review. Rev Rhum Engl Ed. 1995 Jun;62(6 Suppl 1):33S-41S. PubMed PMID: 7583181.
6: Bouron A, Rivet M, Nasri-Sebdani M, Guillemain J, Durbin P, Guerrier D, Raymond G. The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers. Can J Physiol Pharmacol. 1990 Dec;68(12):1503-9. PubMed PMID: 2085796.
7: Tarrús E, García I, Roberts DJ, Segura J. An animal model for the detection of drug-induced inhibition of caffeine metabolism. Methods Find Exp Clin Pharmacol. 1987 May;9(5):311-6. PubMed PMID: 3613760.
8: Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC. Inhibition by idrocilamide of the disposition of caffeine. Eur J Clin Pharmacol. 1980 Jan;17(1):37-43. PubMed PMID: 7371698.
9: Stehman M, Lehert P. [Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago]. Acta Belg Med Phys. 1990 Jan-Mar;13(1):29-32. Dutch, French. PubMed PMID: 2140002.
10: Maier-Lenz H, Ringwelski L, Windorfer A. [Pharmacokinetics and bioavailability of the myotonolytic N-(hydroxy-2-ethyl)-cinnamide (author's transl)]. Arzneimittelforschung. 1980;30(10):1813-6. German. PubMed PMID: 7192119.
11: Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet. 2000 Aug;39(2):127-53. Review. PubMed PMID: 10976659.
12: Upton RA. Pharmacokinetic interactions between theophylline and other medication (Part I). Clin Pharmacokinet. 1991 Jan;20(1):66-80. Review. PubMed PMID: 1674242.
13: Perkin GD, Aminoff MJ. A trial of brolitene in the treatment of spasticity. Br J Clin Pharmacol. 1976 Oct;3(5):879-82. PubMed PMID: 788760; PubMed Central PMCID: PMC1428935.
14: Delwaide PJ. Electrophysiological analysis of the mode of action of muscle relaxants in spasticity. Ann Neurol. 1985 Jan;17(1):90-5. PubMed PMID: 3985591.
15: André P, Descotes J, Simonet R, Evreux JC. Reappraisal of the barbiturate sleeping time in mice as predictive tool for the detection of liver enzymes inhibiting drugs. Methods Find Exp Clin Pharmacol. 1984 Nov;6(11):695-9. PubMed PMID: 6530908.