MedKoo Cat#: 584273 | Name: Idrocilamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Idrocilamide, also known as Brolitene, exhibits anti inflammatory and muscle relaxant properties.

Chemical Structure

Idrocilamide
Idrocilamide
CAS#6961-46-2

Theoretical Analysis

MedKoo Cat#: 584273

Name: Idrocilamide

CAS#: 6961-46-2

Chemical Formula: C11H13NO2

Exact Mass: 191.0946

Molecular Weight: 191.23

Elemental Analysis: C, 69.09; H, 6.85; N, 7.32; O, 16.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Idrocilamide; Brolitene
IUPAC/Chemical Name
2-Propenamide, N-(2-hydroxyethyl)-3-phenyl-
InChi Key
OSCTXCOERRNGLW-VOTSOKGWSA-N
InChi Code
InChI=1S/C11H13NO2/c13-9-8-12-11(14)7-6-10-4-2-1-3-5-10/h1-7,13H,8-9H2,(H,12,14)/b7-6+
SMILES Code
O=C(NCCO)/C=C/C1=CC=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 191.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lery N, Evreux JC, Schwam E, Laisne H. [Letter: Unusual neuropsychic effects due to idrocilamide]. Nouv Presse Med. 1976 Feb 28;5(9):583-4. French. PubMed PMID: 1264724. 2: Bannwarth B, Le Huec JC, Vinçon G, Labat L, Demotes-Mainard F, Rivaille F, Le Rebeller A. [Tissue and systemic diffusion of idrocilamide after cutaneous administration]. Rev Rhum Ed Fr. 1993 Dec;60(12):932-6. French. PubMed PMID: 8012322. 3: Mouzou A, Bouron A, Guillemain J, Guerrier D, Raymond G. Two sites of action for LCB29 (idrocilamide) in depressing mechanical tension of rat soleus muscle fibers? Can J Physiol Pharmacol. 1993 Dec;71(12):889-95. PubMed PMID: 8180884. 4: Lacroix C, Nouveau J, Hubscher P, Tardif D, Ray M, Goulle JP. [Influence of idrocilamide on the metabolism of theophylline]. Rev Pneumol Clin. 1986;42(3):164-6. French. PubMed PMID: 3775181. 5: Trêves R, Maheu E, Dreiser RL. Therapeutic trials in digital osteoarthritis. A critical review. Rev Rhum Engl Ed. 1995 Jun;62(6 Suppl 1):33S-41S. PubMed PMID: 7583181. 6: Bouron A, Rivet M, Nasri-Sebdani M, Guillemain J, Durbin P, Guerrier D, Raymond G. The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers. Can J Physiol Pharmacol. 1990 Dec;68(12):1503-9. PubMed PMID: 2085796. 7: Tarrús E, García I, Roberts DJ, Segura J. An animal model for the detection of drug-induced inhibition of caffeine metabolism. Methods Find Exp Clin Pharmacol. 1987 May;9(5):311-6. PubMed PMID: 3613760. 8: Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC. Inhibition by idrocilamide of the disposition of caffeine. Eur J Clin Pharmacol. 1980 Jan;17(1):37-43. PubMed PMID: 7371698. 9: Stehman M, Lehert P. [Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago]. Acta Belg Med Phys. 1990 Jan-Mar;13(1):29-32. Dutch, French. PubMed PMID: 2140002. 10: Maier-Lenz H, Ringwelski L, Windorfer A. [Pharmacokinetics and bioavailability of the myotonolytic N-(hydroxy-2-ethyl)-cinnamide (author's transl)]. Arzneimittelforschung. 1980;30(10):1813-6. German. PubMed PMID: 7192119. 11: Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet. 2000 Aug;39(2):127-53. Review. PubMed PMID: 10976659. 12: Upton RA. Pharmacokinetic interactions between theophylline and other medication (Part I). Clin Pharmacokinet. 1991 Jan;20(1):66-80. Review. PubMed PMID: 1674242. 13: Perkin GD, Aminoff MJ. A trial of brolitene in the treatment of spasticity. Br J Clin Pharmacol. 1976 Oct;3(5):879-82. PubMed PMID: 788760; PubMed Central PMCID: PMC1428935. 14: Delwaide PJ. Electrophysiological analysis of the mode of action of muscle relaxants in spasticity. Ann Neurol. 1985 Jan;17(1):90-5. PubMed PMID: 3985591. 15: André P, Descotes J, Simonet R, Evreux JC. Reappraisal of the barbiturate sleeping time in mice as predictive tool for the detection of liver enzymes inhibiting drugs. Methods Find Exp Clin Pharmacol. 1984 Nov;6(11):695-9. PubMed PMID: 6530908.