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MedKoo Cat#: 584272 | Name: Brodimoprim
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Brodimoprim is a structural analogue of trimethoprim and a long acting broad spectrum antibacterial agent characterized by a good pharmacokinetic profile.

Chemical Structure

Brodimoprim
Brodimoprim
CAS#56518-41-3

Theoretical Analysis

MedKoo Cat#: 584272

Name: Brodimoprim

CAS#: 56518-41-3

Chemical Formula: C13H15BrN4O2

Exact Mass: 338.0378

Molecular Weight: 339.19

Elemental Analysis: C, 46.03; H, 4.46; Br, 23.56; N, 16.52; O, 9.43

Price and Availability

Size Price Availability Quantity
10mg USD 365.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,450.00 2 Weeks
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Related CAS #
No Data
Synonym
Brodimoprim
IUPAC/Chemical Name
2,4-Diamino-5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine
InChi Key
BFCRRLMMHNLSCP-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18)
SMILES Code
COC1=C(Br)C(OC)=CC(CC2=CN=C(N)N=C2N)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 339.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: De Campora E, Radici M, Camaioni A. Efficacy and tolerability of brodimoprim in otitis. J Chemother. 1993 Dec;5(6):529-31. PubMed PMID: 8195851. 2: Scaglione F, Demartini G, Cocuzza C, Raschi S, Cogo R. Efficacy and tolerability of brodimoprim od versus norfloxacin bid in the treatment of bacterial urinary tract infections. Int J Clin Pharmacol Res. 1995;15(3):121-5. PubMed PMID: 8847153. 3: Caira MR, Bettinetti G, Sorrenti M, Catenacci L. Relationships between structural and thermal properties of anhydrous and solvated crystalline forms of brodimoprim. J Pharm Sci. 2007 May;96(5):996-1007. PubMed PMID: 17455357. 4: Braga PC, Dal Sasso M, Maci S, Allegra L, Fonti E, Ghessi A, Reggio S. Influence of brodimoprim on polymorphonuclear leukocyte phagocytosis and oxidant radical production. Chemotherapy. 1995 Sep-Oct;41(5):360-7. PubMed PMID: 8521738. 5: Bockmeyer M, Riebenfeld D, Clasen B. Controlled study of brodimoprim and cephalexin in the treatment of patients with acute sinusitis in general practice. Clin Ther. 1994 Jul-Aug;16(4):653-61. PubMed PMID: 7982253. 6: Stephan-Güldner M. Preclinical toxicology and safety pharmacology of brodimoprim in comparison to trimethoprim and analogs. J Chemother. 1993 Dec;5(6):400-10. Review. PubMed PMID: 8195831. 7: Scaglione F, Cogo R, Pintucci JP, Demartini G, Dugnani S, Maccarinelli G, Fraschini F. Brodimoprim concentrations in bronchial mucosa, bronchial secretions and middle ear effusions. J Chemother. 1993 Dec;5(6):490-3. PubMed PMID: 8195843. 8: Cosmi EV, Cantini L, Monici Preti PA, Di Renzo GC, Abate F, Balsotti G, Carlomagno G, Cirese E, Indraccolo R, La Sala GB, Mearini L, Minozzi M, Scarpello F. Efficacy and tolerability of brodimoprim at two different dosage schedules in the treatment of acute uncomplicated bacterial cystitis: comparative study vs. pefloxacin. Eur J Obstet Gynecol Reprod Biol. 1996 Feb;64(2):207-11. PubMed PMID: 8820004. 9: Salmi HA. Brodimoprim in acute respiratory tract infections. J Chemother. 1993 Dec;5(6):532-6. PubMed PMID: 8195852. 10: Morgan WD, Birdsall B, Polshakov VI, Sali D, Kompis I, Feeney J. Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase. Biochemistry. 1995 Sep 19;34(37):11690-702. PubMed PMID: 7547901. 11: Moretti M, Marchioni CF, Bisetti A. Efficacy and tolerability of brodimoprim in respiratory tract infections. J Chemother. 1993 Dec;5(6):517-20. PubMed PMID: 8195848. 12: Amyes SG. Comparative antibacterial spectrum of trimethoprim and brodimoprim. J Chemother. 1993 Dec;5(6):417-21. Review. PubMed PMID: 8195832. 13: Manzini M, Caroggio A. Efficacy and tolerability of brodimoprim and roxithromycin in acute sinusitis of bacterial origin in adults. J Chemother. 1993 Dec;5(6):521-5. PubMed PMID: 8195849. 14: Novelli A, Mazzei T, Meli E, Cassetta MI, Fallani S, Periti P. Pharmacokinetics and blister fluid penetration of brodimoprim in adults. J Chemother. 1993 Dec;5(6):494-8. PubMed PMID: 8195844. 15: Nicoletti P, Novelli A, Periti P. In vitro brodimoprim activity on nosocomial bacterial strains. J Chemother. 1993 Dec;5(6):430-4. PubMed PMID: 8195834. 16: Salzberg R. A randomized, open, comparative study of brodimoprim versus erythromycin in patients with acute tonsillitis or bronchitis. J Chemother. 1993 Dec;5(6):546-7. PubMed PMID: 8195854. 17: Birdsall B, Feeney J, Pascual C, Roberts GC, Kompis I, Then RL, Müller K, Kroehn A. A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase. J Med Chem. 1984 Dec;27(12):1672-6. PubMed PMID: 6438320. 18: Stockis A, Borzio F, Deroubaix X, Gaspari F, Jeanbaptiste B, Lebacq E, Lins R, Pavesio D, Pelozi GC, Rosillon D. Pharmacokinetics of brodimoprim in special populations. J Chemother. 1993 Dec;5(6):480-7. PubMed PMID: 8195841. 19: Arndt J, Riebenfeld D, Maier H, Weidauer H. Therapeutic efficacy and tolerability of brodimoprim in comparison with doxycycline in acute sinusitis in adults. J Chemother. 1994 Oct;6(5):322-7. PubMed PMID: 7861197. 20: Weidekamm E. Pharmacokinetics of brodimoprim. J Chemother. 1993 Dec;5(6):475-9. PubMed PMID: 8195840.