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MedKoo Cat#: 328055 | Name: Loviride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Loviride, also known as R-89439, is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection.

Chemical Structure

Loviride
Loviride
CAS#147362-57-0

Theoretical Analysis

MedKoo Cat#: 328055

Name: Loviride

CAS#: 147362-57-0

Chemical Formula: C17H16Cl2N2O2

Exact Mass: 350.0589

Molecular Weight: 351.23

Elemental Analysis: C, 58.14; H, 4.59; Cl, 20.19; N, 7.98; O, 9.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Loviride; R-89439; R 89439; R89439; R 089439; R089439.
IUPAC/Chemical Name
2-((2-acetyl-5-methylphenyl)amino)-2-(2,6-dichlorophenyl)acetamide
InChi Key
CJPLEFFCVDQQFZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H16Cl2N2O2/c1-9-6-7-11(10(2)22)14(8-9)21-16(17(20)23)15-12(18)4-3-5-13(15)19/h3-8,16,21H,1-2H3,(H2,20,23)
SMILES Code
O=C(N)C(NC1=CC(C)=CC=C1C(C)=O)C2=C(Cl)C=CC=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J Mol Biol. 2001 Jun 1;309(2):437-45. PubMed PMID: 11371163. 12: Murphy RL. Nonnucleoside reverse transcriptase inhibitors. AIDS Clin Care. 1997 Oct;9(10):75-7, 79. PubMed PMID: 11364757. 13: Clarke JR, Kaye S, Babiker AG, Hooker MH, Tedder R, Weber JN. Comparison of a point mutation assay with a line probe assay for the detection of the major mutations in the HIV-1 reverse transcriptase gene associated with reduced susceptibility to nucleoside analogues. J Virol Methods. 2000 Aug;88(2):117-24. PubMed PMID: 10960699. 14: Witvrouw M, Pannecouque C, Desmyter J, De Clercq E, Andries K. In vitro evaluation of the effect of temporary removal of HIV drug pressure. Antiviral Res. 2000 Jun;46(3):215-21. PubMed PMID: 10867159. 15: Gatell J, Lange J, Gartland M. AVANTI 1: randomized, double-blind trial to evaluate the efficacy and safety of zidovudine plus lamivudine versus zidovudine plus lamivudine plus loviride in HIV-infected antiretroviral-naive patients. AVANTI Study Group. Antivir Ther. 1999;4(2):79-86. PubMed PMID: 10682152. 16: A randomized trial comparing regimens of four reverse transcriptase inhibitors given together or cyclically in HIV-1 infection--the Quattro Trial. Quattro Steering Committee. AIDS. 1999 Nov 12;13(16):2209-17. PubMed PMID: 10563706. 17: Chatterton ML, Scott-Lennox J, Wu AW, Scott J. Quality of life and treatment satisfaction after the addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens in treatment-experienced patients with HIV infection. Pharmacoeconomics. 1999;15 Suppl 1:67-74. PubMed PMID: 10537443. 18: Witvrouw M, Pannecouque C, Van Laethem K, Desmyter J, De Clercq E, Vandamme AM. Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV. 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