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MedKoo Cat#: 561873 | Name: Alexidine Dihydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alexidine Dihydrochloride is a potent and selective PTPMT1 (Protein Tyrosine Phosphatase Localized to the Mitochondrion 1) inhibitor.

Chemical Structure

Alexidine Dihydrochloride
CAS#1715-30-6

Theoretical Analysis

MedKoo Cat#: 561873

Name: Alexidine Dihydrochloride

CAS#: 1715-30-6

Chemical Formula: C26H58Cl2N10

Exact Mass: 580.4223

Molecular Weight: 581.72

Elemental Analysis: C, 53.68; H, 10.05; Cl, 12.19; N, 24.08

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
100mg USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
Alexidine Dihydrochloride; Alexidine 2HCl;
IUPAC/Chemical Name
1,1"-Hexamethylene-bis(5-[2-ethylhexyl]biguanide)
InChi Key
BRJJFBHTDVWTCJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H56N10.2ClH/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2;;/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);2*1H
SMILES Code
N=C(NC(NCC(CC)CCCC)=N)NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 581.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Olswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun. 2017 Dec 22;8(1):2270. doi: 10.1038/s41467-017-02332-3. PubMed PMID: 29273768; PubMed Central PMCID: PMC5741634. 2: Callahan D, Kovacs C, Lynch S, Rah M. Biocidal efficacy of multipurpose solutions against Gram-negative organisms associated with corneal infiltrative events. Clin Exp Optom. 2017 Jul;100(4):357-364. doi: 10.1111/cxo.12509. Epub 2017 Feb 14. PubMed PMID: 28194876; PubMed Central PMCID: PMC5516204. 3: Zhu X, Gao J, Ng PY, Qin A, Steer JH, Pavlos NJ, Zheng MH, Dong Y, Cheng TS. Alexidine Dihydrochloride Attenuates Osteoclast Formation and Bone Resorption and Protects Against LPS-Induced Osteolysis. J Bone Miner Res. 2016 Mar;31(3):560-72. doi: 10.1002/jbmr.2710. Epub 2016 Jan 6. PubMed PMID: 26363136. 4: Liu X, Zheng H, Yu WM, Cooper TM, Bunting KD, Qu CK. Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood. 2015 Mar 5;125(10):1562-5. doi: 10.1182/blood-2014-04-568949. Epub 2015 Jan 15. PubMed PMID: 25593337; PubMed Central PMCID: PMC4351504. 5: Tilia D, Lazon de la Jara P, Weng R, Naduvilath T, Willcox MD. Short-term clinical comparison of two dual-disinfection multipurpose disinfecting solutions. Eye Contact Lens. 2014 Jan;40(1):7-11. doi: 10.1097/01.ICL.0000436270.08502.d3. PubMed PMID: 24296957. 6: Omali NB, Zhao Z, Zhu H, Tilia D, Willcox MD. Quantification of individual proteins in silicone hydrogel contact lens deposits. Mol Vis. 2013;19:390-9. Epub 2013 Feb 18. PubMed PMID: 23441110; PubMed Central PMCID: PMC3580989. 7: Chan CY, Prudom C, Raines SM, Charkhzarrin S, Melman SD, De Haro LP, Allen C, Lee SA, Sklar LA, Parra KJ. Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p). J Biol Chem. 2012 Mar 23;287(13):10236-50. doi: 10.1074/jbc.M111.321133. Epub 2012 Jan 3. PubMed PMID: 22215674; PubMed Central PMCID: PMC3323027. 8: Soares DA, de Andrade RV, Silva SS, Bocca AL, Soares Felipe SM, Petrofeza S. Extracellular Paracoccidioides brasiliensis phospholipase B involvement in alveolar macrophage interaction. BMC Microbiol. 2010 Sep 15;10:241. doi: 10.1186/1471-2180-10-241. PubMed PMID: 20843362; PubMed Central PMCID: PMC2949701. 9: Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon JE, Casey PJ. Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J Pharmacol Exp Ther. 2010 May;333(2):584-92. doi: 10.1124/jpet.109.163329. Epub 2010 Feb 18. PubMed PMID: 20167843; PubMed Central PMCID: PMC2872949. 10: Yip KW, Ito E, Mao X, Au PY, Hedley DW, Mocanu JD, Bastianutto C, Schimmer A, Liu FF. Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol Cancer Ther. 2006 Sep;5(9):2234-40. PubMed PMID: 16985057. 11: Ganendren R, Widmer F, Singhal V, Wilson C, Sorrell T, Wright L. In vitro antifungal activities of inhibitors of phospholipases from the fungal pathogen Cryptococcus neoformans. Antimicrob Agents Chemother. 2004 May;48(5):1561-9. PubMed PMID: 15105106; PubMed Central PMCID: PMC400561. 12: Shern RJ. Effects of various organic compounds and fluoride on dental plaque and caries in rats. Caries Res. 1988;22(3):181-6. PubMed PMID: 3131014. 13: Curtis SN, Dooley CL. Cariostatic activity of (1,6-bis-[2-ethylhexylbiguanido]-hexane) in conventional rats. J Dent Res. 1979 Apr;58(4):1405-12. PubMed PMID: 285110. 14: Pinzauti S, La Porta E, De Sio F. Gravimetric quantitation of alexidine dihydrochloride and its dosage forms. J Pharm Belg. 1979 Mar-Apr;34(2):101-3. PubMed PMID: 512819. 15: Spolsky VW, Forsythe AB. Effects of alexidine.2HCL mouthwash on plaque and gingivitis after six months. J Dent Res. 1977 Nov;56(11):1349-58. PubMed PMID: 348734. 16: Shern RJ, Amsbaugh SM, Reynolds R. Effects of daily rinses using sodium fluoride and organic fluorides on rat caries. J Dent Res. 1977 Sep;56(9):1063-6. PubMed PMID: 270503. 17: Spolsky VW, Bhatia HL, Forsythe A, Levin D. The effect of an antimicrobial mouthwash on dental plaque and gingivitis in yound adults. J Periodontol. 1975 Nov;46(11):685-90. PubMed PMID: 1102656. 18: Duany LF, Zinner DD. Longitudinal effects of an antibacterial oral rinse on gingivitis and dental plaque. Pharmacol Ther Dent. 1975;2(3-4):229-34. PubMed PMID: 1073187.

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SGI-7079

SGI-7079

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