RO-09-4879 is a CaNMT inhibitor (IC50 = 5.7 nM) with good fungal selectivity. CaNMT inhibitors are fungicidal and show antifungal activity against Candida (especially fluconazole-resistant strains). They function by inhibiting N-myristoyltransferase (NMT), which catalyzes the transfer of a C14 fatty acif from myristoyl-CoA to the N-terminal of glycine in many fungal proteins. Without this process, fungi can die. This process also occurs in humans, and as such selectivity is an important characteristic of these drugs.
MedKoo Cat#: 571474
Name: RO-09-04879
CAS#: N/A
Chemical Formula: C25H23F3N2O3
Exact Mass: 456.1661
Molecular Weight: 456.47
Elemental Analysis: C, 65.78; H, 5.08; F, 12.49; N, 6.14; O, 10.51
The following data is based on the product molecular weight 456.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
 trifluoroacetate salt2259.jpg "GLP-1 (7-15) trifluoroacetate salt")