Synonym
MBX-4132; MBX 4132; MBX4132;
IUPAC/Chemical Name
N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
InChi Key
OZHWSOOZCIJFQN-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H15FN4O2/c19-15-7-5-13(6-8-15)16-21-22-17(25-16)20-18(24)23-10-9-12-3-1-2-4-14(12)11-23/h1-8H,9-11H2,(H,20,22,24)
SMILES Code
O=C(NC1=NN=C(C2=CC=C(F)C=C2)O1)N3CCC4=CC=CC=C4C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
MBX-4132, a member of a chemical class called oxadiazoles that inhibit trans translation by binding to the bacterial ribosome.
In vivo activity:
Here, this study reports optimization of the pharmacokinetic and antibiotic properties of the acylaminooxadiazoles, producing MBX-4132, which clears multiple-drug resistant Neisseria gonorrhoeae infection in mice after a single oral dose.
Reference: Nat Commun. 2021 Mar 19;12(1):1799. https://pubmed.ncbi.nlm.nih.gov/33741965/
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
25.0 |
73.89 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
338.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
Aron ZD, Mehrani A, Hoffer ED, Connolly KL, Srinivas P, Torhan MC, Alumasa JN, Cabrera M, Hosangadi D, Barbor JS, Cardinale SC, Kwasny SM, Morin LR, Butler MM, Opperman TJ, Bowlin TL, Jerse A, Stagg SM, Dunham CM, Keiler KC. trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nat Commun. 2021 Mar 19;12(1):1799. doi: 10.1038/s41467-021-22012-7. PMID: 33741965; PMCID: PMC7979765.
In vivo protocol:
Aron ZD, Mehrani A, Hoffer ED, Connolly KL, Srinivas P, Torhan MC, Alumasa JN, Cabrera M, Hosangadi D, Barbor JS, Cardinale SC, Kwasny SM, Morin LR, Butler MM, Opperman TJ, Bowlin TL, Jerse A, Stagg SM, Dunham CM, Keiler KC. trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nat Commun. 2021 Mar 19;12(1):1799. doi: 10.1038/s41467-021-22012-7. PMID: 33741965; PMCID: PMC7979765.
1: Varshney A, Jia Z, Howe MD, Keiler KC, Baughn AD. A trans-translation
inhibitor is potentiated by zinc and kills Mycobacterium tuberculosis and
non-tuberculous mycobacteria. bioRxiv [Preprint]. 2024 Nov 2:2024.11.02.621434.
doi: 10.1101/2024.11.02.621434. PMID: 39554143; PMCID: PMC11566007.
2: Naclerio GA, Onyedibe KI, Karanja CW, Aryal UK, Sintim HO. Comparative
Studies to Uncover Mechanisms of Action of
N-(1,3,4-Oxadiazol-2-yl)benzamide Containing Antibacterial Agents. ACS
Infect Dis. 2022 Apr 8;8(4):865-877. doi: 10.1021/acsinfecdis.1c00613. Epub 2022
Mar 17. PMID: 35297603; PMCID: PMC9188027.
3: Aron ZD, Mehrani A, Hoffer ED, Connolly KL, Srinivas P, Torhan MC, Alumasa
JN, Cabrera M, Hosangadi D, Barbor JS, Cardinale SC, Kwasny SM, Morin LR, Butler
MM, Opperman TJ, Bowlin TL, Jerse A, Stagg SM, Dunham CM, Keiler KC. trans-
Translation inhibitors bind to a novel site on the ribosome and clear Neisseria
gonorrhoeae in vivo. Nat Commun. 2021 Mar 19;12(1):1799. doi:
10.1038/s41467-021-22012-7. PMID: 33741965; PMCID: PMC7979765.
