Synonym
BO 1236; BO1236; BO-1236
IUPAC/Chemical Name
1H-Isoindolium, 2-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-2,3-dihydro-5,6-dihydroxy-2-methyl-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-
InChi Key
QDBUMQXESHMJDI-AVRDEDQJSA-N
InChi Code
InChI=1S/C26H28N6O9S2/c1-26(2,24(39)40)41-30-17(14-10-43-25(27)28-14)20(35)29-18-21(36)31-19(23(37)38)13(9-42-22(18)31)8-32(3)6-11-4-15(33)16(34)5-12(11)7-32/h4-5,10,18,22H,6-9H2,1-3H3,(H6-,27,28,29,30,33,34,35,37,38,39,40)/t18-,22-/m0/s1
SMILES Code
C[N+]1(CC(CS[C@@]2([H])[C@H]3NC(/C(C4=CSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N2C3=O)CC5=C(C=C(O)C(O)=C5)C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
632.66
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nakagawa S, Sanada M, Matsuda K, Hazumi N, Tanaka N. Biological activity of BO-1236, a new antipseudomonal cephalosporin. Antimicrob Agents Chemother. 1987 Jul;31(7):1100-5. PubMed PMID: 3116919; PubMed Central PMCID: PMC174878.
2: Valiant ME, Gilfillan EC, Gadebusch HH, Pelak BA. L-658,310, a new injectable cephalosporin. II. In vitro and in vivo interactions between L-658,310 and various aminoglycosides or ciprofloxacin versus clinical isolates of Pseudomonas aeruginosa. J Antibiot (Tokyo). 1989 May;42(5):807-14. PubMed PMID: 2498278.
3: Weissberger BA, Abruzzo GK, Fromtling RA, Gill C, Ponticas S, Valiant ME, Shungu DL, Gadebusch HH. L-658,310, a new injectable cephalosporin. I. In vitro antibacterial properties. J Antibiot (Tokyo). 1989 May;42(5):795-806. PubMed PMID: 2498277.
4: Hashizume T, Sanada M, Nakagawa S, Tanaka N. Comparison of transport pathways of catechol-substituted cephalosporins, BO-1236 and BO-1341, through the outer membrane of Escherichia coli. J Antibiot (Tokyo). 1990 Dec;43(12):1617-20. PubMed PMID: 2276982.
5: Gilfillan EC, Pelak BA, Weissberger BA, Abruzzo GK, Fromtling RA, Bland JA, Hadley SK, Gadebusch HH. L-658,310, a new injectable cephalosporin. III. Experimental chemotherapeutics and pharmacokinetics in laboratory animals. J Antibiot (Tokyo). 1989 May;42(5):815-22. PubMed PMID: 2656617.
