Evoxine | CAS#522-11-2

MedKoo Cat#: 527670 | Name: Evoxine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Evoxine is a first-in-class, selective inhibitor of CO2-induced immune suppression, inhibiting hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages.

Chemical Structure

Evoxine

CAS#522-11-2

Theoretical Analysis

MedKoo Cat#: 527670

Name: Evoxine

CAS#: 522-11-2

Chemical Formula: C18H21NO6

Exact Mass: 347.1369

Molecular Weight: 347.37

Elemental Analysis: C, 62.24; H, 6.09; N, 4.03; O, 27.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Evoxine

IUPAC/Chemical Name

1-(4,8-Dimethoxyfuro[2,3-b]quinolin-7-yl)oxy-3-methylbutane-2,3-diol

InChi Key

FGANMDNHTVJAHL-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H21NO6/c1-18(2,21)13(20)9-25-12-6-5-10-14(16(12)23-4)19-17-11(7-8-24-17)15(10)22-3/h5-8,13,20-21H,9H2,1-4H3

SMILES Code

CC(O)(C)C(O)COC1=CC=C2C(OC)=C3C(OC=C3)=NC2=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 347.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kouam ADK, Bissoue AN, Tcho AT, Happi EN, Waffo AFK, Sewald N, Wansi JD. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules. 2017 Dec 21;23(1). pii: E13. doi: 10.3390/molecules23010013. PubMed PMID: 29267257. 2: Helenius IT, Nair A, Bittar HE, Sznajder JI, Sporn PH, Beitel GJ. Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression. J Biomol Screen. 2016 Apr;21(4):363-71. doi: 10.1177/1087057115624091. Epub 2015 Dec 23. PubMed PMID: 26701099; PubMed Central PMCID: PMC5096368. 3: Kiplimo JJ, Islam MS, Koorbanally NA. A novel flavonoid and furoquinoline alkaloids from Vepris glomerata and their antioxidant activity. Nat Prod Commun. 2011 Dec;6(12):1847-50. PubMed PMID: 22312722. 4: Chu CC, Pan KL, Yao HT, Hsu JT. Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism. Biotechnol Bioeng. 2011 Dec;108(12):2932-40. doi: 10.1002/bit.23256. Epub 2011 Aug 1. PubMed PMID: 21755496. 5: Cuca Suarez LE, Pattarroyo ME, Lozano JM, Delle Monache F. Biological activity of secondary metabolites from Peltostigma guatemalense. Nat Prod Res. 2009;23(4):370-4. doi: 10.1080/14786410802228439. PubMed PMID: 19296377. 6: Boyd DR, Sharma ND, Loke PL, Malone JF, McRoberts WC, Hamilton JT. Synthesis, structure and stereochemistry of quinoline alkaloids from Choisya ternata. Org Biomol Chem. 2007 Sep 21;5(18):2983-91. Epub 2007 Aug 7. PubMed PMID: 17728865. 7: Waffo AF, Coombes PH, Crouch NR, Mulholland DA, El Amin SM, Smith PJ. Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa. Phytochemistry. 2007 Mar;68(5):663-7. Epub 2006 Dec 15. PubMed PMID: 17174364. 8: Moulis C, Gleye J, Fourasté I, Stanislas E. [New furoquinolins from Monnieria trifolia]. Planta Med. 1981 Aug;42(8):400-2. German. PubMed PMID: 17401996.