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MedKoo Cat#: 527653 | Name: CPI-169 R-isomer

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CPI-169 R-isomer is an isomer of CPI-169. CP169 is a potent inhibitor of enhancer of zeste homolog 2 (EZH2) with an IC50 value of <1nM for polycomb repressive complex 2 (PRC2). CPI-169 was shown to inhibit tumor growth in a NHL xenograft model, reducing global H3K27me3.1 It has also been shown to synergize with the B-cell lymphoma inhibitor, ABT-199, to suppress the growth of NHL cell lines

Chemical Structure

CPI-169 R-isomer
CPI-169 R-isomer
CAS#1802175-07-0 (R-isomer)

Theoretical Analysis

MedKoo Cat#: 527653

Name: CPI-169 R-isomer

CAS#: 1802175-07-0 (R-isomer)

Chemical Formula: C27H36N4O5S

Exact Mass: 528.2406

Molecular Weight: 528.67

Elemental Analysis: C, 61.34; H, 6.86; N, 10.60; O, 15.13; S, 6.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1450655-76-1 (racemic mixture) 1802175-07-0 (R-isomer)
Synonym
CPI-169; CPI169; CPI 169 (R); CPI-169 R-isomer; (R)-CPI-169.
IUPAC/Chemical Name
(R)-1-[1-(1-Ethylsulfonylpiperidin-4-yl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylindole-3-carboxamide
InChi Key
LHGUZCKPFXXVPV-GOSISDBHSA-N
InChi Code
InChI=1S/C27H36N4O5S/c1-6-37(34,35)30-13-11-20(12-14-30)18(3)31-19(4)25(21-9-7-8-10-23(21)31)27(33)28-16-22-24(36-5)15-17(2)29-26(22)32/h7-10,15,18,20H,6,11-14,16H2,1-5H3,(H,28,33)(H,29,32)/t18-/m1/s1
SMILES Code
O=C(C1=C(C)N([C@@H](C2CCN(S(=O)(CC)=O)CC2)C)C3=C1C=CC=C3)NCC4=C(OC)C=C(C)NC4=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 528.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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