IRAK-1/4 Inhibitor is a small-molecule compound that selectively targets interleukin-1 receptor-associated kinases 1 and 4 (IRAK1/4), key mediators in Toll-like receptor (TLR) and IL-1 receptor (IL-1R) signaling pathways. By inhibiting these kinases, the compound effectively blocks downstream activation of NF-κB and MAPK pathways, reducing the production of pro-inflammatory cytokines such as TNF-α and IL-6. It has demonstrated anti-inflammatory and immunomodulatory bioactivity, making it a promising therapeutic candidate for treating autoimmune diseases, chronic inflammation, and certain hematologic malignancies.
MedKoo Cat#: 527650
Name: IRAK-1/4 Inhibitor
CAS#: 509093-47-4
Chemical Formula: C20H21N5O4
Exact Mass: 395.1594
Molecular Weight: 395.42
Elemental Analysis: C, 60.75; H, 5.35; N, 17.71; O, 16.18
The following data is based on the product molecular weight 395.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
