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MedKoo Cat#: 128345 | Name: FF2049

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FF2049 is a FEM1B-Recruiting Histone Deacetylase Degrader (Dmax = 85%; DC50 = 257 nM).

Chemical Structure

FF2049
FF2049
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128345

Name: FF2049

CAS#: N/A

Chemical Formula: C31H38ClN7O7

Exact Mass: 655.2521

Molecular Weight: 656.14

Elemental Analysis: C, 56.75; H, 5.84; Cl, 5.40; N, 14.94; O, 17.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
FF2049; FF-2049; FF 2049
IUPAC/Chemical Name
4-(2-(2-(7-(2-chloro-N-(2-cyanoethyl)acetamido)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)acetamido)acetamido)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide
InChi Key
RKOIKQJKAURNHQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H38ClN7O7/c32-19-30(43)39(15-5-13-33)24-11-12-25-26(18-24)46-17-16-38(25)21-29(42)35-20-28(41)36-23-9-7-22(8-10-23)31(44)34-14-4-2-1-3-6-27(40)37-45/h7-12,18,45H,1-6,14-17,19-21H2,(H,34,44)(H,35,42)(H,36,41)(H,37,40)
SMILES Code
O=C(NCCCCCCC(NO)=O)C1=CC=C(NC(CNC(CN2C3=CC=C(N(CCC#N)C(CCl)=O)C=C3OCC2)=O)=O)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 656.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Feller F, Honin I, Miranda M, Weber H, Henze S, Hanl M, Hansen FK. Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders. J Med Chem. 2025 Jan 13. doi: 10.1021/acs.jmedchem.4c02569. Epub ahead of print. PMID: 39804678.

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