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MedKoo Cat#: 561781 | Name: EC-17 sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

EC17, also known as Folate-FITC, is an FITC conjugated folic acid. It also acts as a FRα-targeting agent that fluoresces at 500nm. EC17 is conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity. Folate-FITC binds to folate receptors, which are overexpressed on the surfaces of many cancer cells including kidney and ovarian cancer cells. Once bound to the cancer cell through the folate moiety of the conjugate, curculating anti-fluorescein antibodies.may recognize and bind to the FITC moiety, resulting in antibody-dependent cellular cytotoxicity.

Chemical Structure

EC-17 sodium
EC-17 sodium
CAS#910661-33-5 (sodium)

Theoretical Analysis

MedKoo Cat#: 561781

Name: EC-17 sodium

CAS#: 910661-33-5 (sodium)

Chemical Formula: C42H35N10NaO10S

Exact Mass: 0.0000

Molecular Weight: 894.85

Elemental Analysis: C, 56.37; H, 3.94; N, 15.65; Na, 2.57; O, 17.88; S, 3.58

Price and Availability

Size Price Availability Quantity
5mg USD 1,350.00 2 Weeks
10mg USD 2,350.00 2 Weeks
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Related CAS #
910661-33-5 (sodium) 583037-91-6 (free acid)
Synonym
EC17; EC-17; EC 17; Folate-FTIC; FTIC-Folate; EC17 sodium.
IUPAC/Chemical Name
sodium N2-(4-(((2-amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)amino)benzoyl)-N5-(2-(3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thioureido)ethyl)-L-glutaminate
InChi Key
MNSDNHVYFRRWJX-CZCBIWLKSA-M
InChi Code
InChI=1S/C42H36N10O10S.Na/c43-40-51-35-34(37(57)52-40)48-23(19-47-35)18-46-21-3-1-20(2-4-21)36(56)50-30(38(58)59)11-12-33(55)44-13-14-45-41(63)49-22-5-8-27-26(15-22)39(60)62-42(27)28-9-6-24(53)16-31(28)61-32-17-25(54)7-10-29(32)42;/h1-10,15-17,19,30,46,53-54H,11-14,18H2,(H,44,55)(H,50,56)(H,58,59)(H2,45,49,63)(H3,43,47,51,52,57);/q;+1/p-1/t30-;/m0./s1
SMILES Code
O=C1OC2(C=3C1=CC(NC(NCCNC(CC[C@H](NC(=O)C4=CC=C(NCC=5N=C6C(NC5)=NC(N)=NC6=O)C=C4)C(O)=O)=O)=S)=CC3)C=7C(OC=8C2=CC=C(O)C8)=CC(O)=CC7.[Na]
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#M23C06E26
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 894.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kishore V, Patil AG. Expression of p16INK4A Protein in Cervical Intraepithelial Neoplasia and Invasive Carcinoma of Uterine Cervix. J Clin Diagn Res. 2017 Sep;11(9):EC17-EC20. doi: 10.7860/JCDR/2017/29394.10644. Epub 2017 Sep 1. PubMed PMID: 29207716; PubMed Central PMCID: PMC5713738. 2: Balasubramanian P, Badhe BA, Ganesh RN, Panicker LC, Mohan P. Morphologic Spectrum of Duodenal Biopsies in Malabsorption: A Study from Southern India. J Clin Diagn Res. 2017 Jul;11(7):EC17-EC21. doi: 10.7860/JCDR/2017/23871.10231. Epub 2017 Jul 1. PubMed PMID: 28892904; PubMed Central PMCID: PMC5583821. 3: Venkataswamy C, Devi AS. Clinico-Haematological Profile of Hereditary Haemolytic Anaemias in a Tertiary Health Care Hospital in South India. J Clin Diagn Res. 2017 Jun;11(6):EC17-EC21. doi: 10.7860/JCDR/2017/25366.10023. Epub 2017 Jun 1. PubMed PMID: 28764172; PubMed Central PMCID: PMC5535365. 4: Kulkarni MM, Khandeparkar SGS, Joshi AR, Kakade A, Fegade L, Narkhede K. Clinicopathological Study of Carcinoma of the Ampulla of Vater with Special Reference to MUC1, MUC2 and MUC5AC Expression. J Clin Diagn Res. 2017 May;11(5):EC17-EC20. doi: 10.7860/JCDR/2017/26842.9830. Epub 2017 May 1. PubMed PMID: 28658766; PubMed Central PMCID: PMC5483668. 5: Predina JD, Okusanya O, D Newton A, Low P, Singhal S. Standardization and Optimization of Intraoperative Molecular Imaging for Identifying Primary Pulmonary Adenocarcinomas. Mol Imaging Biol. 2017 May 11. doi: 10.1007/s11307-017-1076-8. [Epub ahead of print] PubMed PMID: 28497233. 6: Holah NS, Aiad HA, Asaad NY, Elkhouly EA, Lasheen AG. Evaluation of the Role of ALDH1 as Cancer Stem Cell Marker in Colorectal Carcinoma: An Immunohistochemical Study. J Clin Diagn Res. 2017 Jan;11(1):EC17-EC23. doi: 10.7860/JCDR/2017/22671.9291. Epub 2017 Jan 1. PubMed PMID: 28273973; PubMed Central PMCID: PMC5324418. 7: Samaka RM, Younes SF. Androgen Receptor Expression in Breast Carcinoma of Egyptian Patients. J Clin Diagn Res. 2016 Nov;10(11):EC17-EC21. doi: 10.7860/JCDR/2016/23364.8919. Epub 2016 Nov 1. PubMed PMID: 28050375; PubMed Central PMCID: PMC5198328. 8: Agrawal PB, Rane SR, Jadhav MV. Absolute Lymphocyte Count as a Surrogate Marker of CD4 Count in Monitoring HIV Infected Individuals: A Prospective Study. J Clin Diagn Res. 2016 May;10(5):EC17-9. doi: 10.7860/JCDR/2016/19263.7765. Epub 2016 May 1. PubMed PMID: 27437225; PubMed Central PMCID: PMC4948401. 9: Tummers QR, Hoogstins CE, Gaarenstroom KN, de Kroon CD, van Poelgeest MI, Vuyk J, Bosse T, Smit VT, van de Velde CJ, Cohen AF, Low PS, Burggraaf J, Vahrmeijer AL. Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17. Oncotarget. 2016 May 31;7(22):32144-55. doi: 10.18632/oncotarget.8282. PubMed PMID: 27014973; PubMed Central PMCID: PMC5078003. 10: Garg S, Desai NJ, Mehta D, Vaishnav M. To Establish Bethesda System for Diagnosis of Thyroid Nodules on the Basis of Fnac with Histopathological Correlation. J Clin Diagn Res. 2015 Dec;9(12):EC17-21. doi: 10.7860/JCDR/2015/14823.6897. Epub 2015 Dec 1. PubMed PMID: 26816898; PubMed Central PMCID: PMC4717753. 11: Kanodia KV, Vanikar AV, Modi PR, Patel RD, Suthar KS, Nigam LK, Trivedi HL. Histological and Clinicopathological Evaluation of Liver Allograft Biopsy: An Initial Experience of Fifty Six Biopsies. J Clin Diagn Res. 2015 Nov;9(11):EC17-20. doi: 10.7860/JCDR/2015/13664.6812. Epub 2015 Nov 1. PubMed PMID: 26673862; PubMed Central PMCID: PMC4668416. 12: Guzzo TJ, Jiang J, Keating J, DeJesus E, Judy R, Nie S, Low P, Lal P, Singhal S. Intraoperative Molecular Diagnostic Imaging Can Identify Renal Cell Carcinoma. J Urol. 2016 Mar;195(3):748-55. doi: 10.1016/j.juro.2015.09.093. Epub 2015 Nov 2. PubMed PMID: 26541080. 13: De Jesus E, Keating JJ, Kularatne SA, Jiang J, Judy R, Predina J, Nie S, Low P, Singhal S. Comparison of Folate Receptor Targeted Optical Contrast Agents for Intraoperative Molecular Imaging. Int J Mol Imaging. 2015;2015:469047. doi: 10.1155/2015/469047. Epub 2015 Sep 28. PubMed PMID: 26491562; PubMed Central PMCID: PMC4600912. 14: Amato RJ, Shetty A, Lu Y, Ellis PR, Mohlere V, Carnahan N, Low PS. A Phase I/Ib study of folate immune (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) with interferon-α and interleukin-2 in patients with renal cell carcinoma. J Immunother. 2014 May;37(4):237-44. doi: 10.1097/CJI.0000000000000029. PubMed PMID: 24714357. 15: Amato RJ, Shetty A, Lu Y, Ellis R, Low PS. A phase I study of folate immune therapy (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) in patients with renal cell carcinoma. J Immunother. 2013 May;36(4):268-75. doi: 10.1097/CJI.0b013e3182917f59. PubMed PMID: 23603861. 16: Sawada M, Kubo S, Matsumura K, Takemoto Y, Kobayashi H, Tashiro E, Kitahara T, Watanabe H, Imoto M. Synthesis and anti-migrative evaluation of moverastin derivatives. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1385-9. doi: 10.1016/j.bmcl.2011.01.028. Epub 2011 Jan 11. PubMed PMID: 21306898. 17: Takemoto Y, Watanabe H, Uchida K, Matsumura K, Nakae K, Tashiro E, Shindo K, Kitahara T, Imoto M. Chemistry and biology of moverastins, inhibitors of cancer cell migration, produced by Aspergillus. Chem Biol. 2005 Dec;12(12):1337-47. PubMed PMID: 16356851. 18: Avelar KE, Otsuki K, Vicente AC, Vieira JM, de Paula GR, Domingues RM, Ferreira MC. Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. PubMed PMID: 12837513. 19: Nakae K, Yoshimoto Y, Sawa T, Homma Y, Hamada M, Takeuchi T, Imoto M. Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000 Oct;53(10):1130-6. PubMed PMID: 11132958. 20: Chargaff E. Molecular slavery. J Biosci. 2000 Mar;25(1):7-8. PubMed PMID: 10824191.