MedKoo Cat#: 584192 | Name: BI-44370
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BI-44370 is a CGRP (calcitonin gene-related peptide) receptor antagonist that can be used to treat migraines and other chronic pain.Efficacy of BI 44370 TA was shown in a dose-dependent manner in the treatment of acute migraine attacks.

Chemical Structure

BI-44370
BI-44370
CAS#866086-05-7 (free base)

Theoretical Analysis

MedKoo Cat#: 584192

Name: BI-44370

CAS#: 866086-05-7 (free base)

Chemical Formula: C35H47N5O6

Exact Mass: 633.3526

Molecular Weight: 633.79

Elemental Analysis: C, 66.33; H, 7.48; N, 11.05; O, 15.15

Price and Availability

Size Price Availability Quantity
1mg USD 150.00 Ready to Ship
5mg USD 550.00 Ready to Ship
10mg USD 950.00 Ready to Ship
25mg USD 1,650.00 Ready to Ship
50mg USD 2,950.00 Ready to Ship
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Related CAS #
952508-87-1 (HCl) 866086-05-7 (free base) 952508-84-8 (HBr) 952508-93-9 (1tartrate) 952508-96-2 (2tartrate)
Synonym
BI-44370; BI44370; BI 44370;
IUPAC/Chemical Name
4-(2-Oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-yl)piperidine-1-carboxylic acid (R)-alpha-((4-morpholinopiperidino)carbonyl)-3,5-dimethyl-4-hydroxyphenethyl ester
InChi Key
HTLWMOKBJQKDIJ-WJOKGBTCSA-N
InChi Code
InChI=1S/C35H47N5O6/c1-24-21-26(22-25(2)32(24)41)23-31(33(42)38-12-8-28(9-13-38)37-17-19-45-20-18-37)46-35(44)39-14-10-29(11-15-39)40-16-7-27-5-3-4-6-30(27)36-34(40)43/h3-6,21-22,28-29,31,41H,7-20,23H2,1-2H3,(H,36,43)/t31-/m1/s1
SMILES Code
O=C(N1CCC(N2C(NC3=CC=CC=C3CC2)=O)CC1)O[C@@H](C(N4CCC(N5CCOCC5)CC4)=O)CC6=CC(C)=C(O)C(C)=C6
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
CGRP antagonist 2 is a CGRP receptor antagonist.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 633.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Diener HC, Barbanti P, Dahlöf C, Reuter U, Habeck J, Podhorna J. BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia. 2011 Apr;31(5):573-84. doi: 10.1177/0333102410388435. Epub 2010 Dec 20. PubMed PMID: 21172952. 2: Hougaard A, Tfelt-Hansen P. Review of dose-response curves for acute antimigraine drugs: triptans, 5-HT1F agonists and CGRP antagonists. Expert Opin Drug Metab Toxicol. 2015;11(9):1409-18. doi: 10.1517/17425255.2015.1055244. Epub 2015 Jun 26. Review. PubMed PMID: 26095133. 3: Negro A, Lionetto L, Simmaco M, Martelletti P. CGRP receptor antagonists: an expanding drug class for acute migraine? Expert Opin Investig Drugs. 2012 Jun;21(6):807-18. doi: 10.1517/13543784.2012.681044. Epub 2012 Apr 19. Review. PubMed PMID: 22512641. 4: Palme O, Moszyk A, Iphöfer D, Lang S. Selected microbial glycolipids: production, modification and characterization. Adv Exp Med Biol. 2010;672:185-202. Review. PubMed PMID: 20545283. 5: Hoffmann J, Goadsby PJ. New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors. Curr Treat Options Neurol. 2012 Feb;14(1):50-9. doi: 10.1007/s11940-011-0155-4. PubMed PMID: 22090312. 6: Durham PL, Vause CV. Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine. CNS Drugs. 2010 Jul;24(7):539-48. doi: 10.2165/11534920-000000000-00000. PubMed PMID: 20433208; PubMed Central PMCID: PMC3138175.