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MedKoo Cat#: 561766 | Name: Fluorizoline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluorizoline is a first-in-class inducer of p53-independent apoptosis in a wide range of tumor cell lines. It directly binds to prohibitin 1 and 2 (PHBs), two proteins involved in the regulation of several cellular processes, including apoptosis.

Chemical Structure

Fluorizoline
Fluorizoline
CAS#1362243-70-6

Theoretical Analysis

MedKoo Cat#: 561766

Name: Fluorizoline

CAS#: 1362243-70-6

Chemical Formula: C15H8Cl2F3NS

Exact Mass: 360.9707

Molecular Weight: 362.19

Elemental Analysis: C, 49.74; H, 2.23; Cl, 19.58; F, 15.74; N, 3.87; S, 8.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fluorizoline;
IUPAC/Chemical Name
2,5-Bis-(4-chloro-phenyl)-4,4,5-trifluoro-4,5-dihydro-thiazole
InChi Key
JGDLZQYCDVDWNE-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H8Cl2F3NS/c16-11-5-1-9(2-6-11)13-21-15(19,20)14(18,22-13)10-3-7-12(17)8-4-10/h1-8H
SMILES Code
FC1(C2=CC=C(Cl)C=C2)C(F)(F)N=C(C3=CC=C(Cl)C=C3)S1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 362.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wierz M, Pierson S, Chouha N, Désaubry L, François JH, Berchem G, Paggetti J, Moussay E. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model. Haematologica. 2018 Jan 5. pii: haematol.2017.175349. doi: 10.3324/haematol.2017.175349. [Epub ahead of print] PubMed PMID: 29305413. 2: Cosialls AM, Pomares H, Iglesias-Serret D, Saura-Esteller J, Núñez-Vázquez S, González-Gironès DM, de la Banda E, Preciado S, Albericio F, Lavilla R, Pons G, González-Barca EM, Gil J. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. Haematologica. 2017 Sep;102(9):1587-1593. doi: 10.3324/haematol.2016.162958. Epub 2017 Jun 15. PubMed PMID: 28619845; PubMed Central PMCID: PMC5685241. 3: Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, Désaubry L, Rajalingam K. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017 Aug 17;36(33):4778-4789. doi: 10.1038/onc.2017.93. Epub 2017 Apr 17. Erratum in: Oncogene. 2017 Aug 28;:. PubMed PMID: 28414306. 4: Pomares H, Palmeri CM, Iglesias-Serret D, Moncunill-Massaguer C, Saura-Esteller J, Núñez-Vázquez S, Gamundi E, Arnan M, Preciado S, Albericio F, Lavilla R, Pons G, González-Barca EM, Cosialls AM, Gil J. Targeting prohibitins induces apoptosis in acute myeloid leukemia cells. Oncotarget. 2016 Oct 4;7(40):64987-65000. doi: 10.18632/oncotarget.11333. PubMed PMID: 27542247; PubMed Central PMCID: PMC5323132. 5: Moncunill-Massaguer C, Saura-Esteller J, Pérez-Perarnau A, Palmeri CM, Núñez-Vázquez S, Cosialls AM, González-Gironès DM, Pomares H, Korwitz A, Preciado S, Albericio F, Lavilla R, Pons G, Langer T, Iglesias-Serret D, Gil J. A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget. 2015 Dec 8;6(39):41750-65. doi: 10.18632/oncotarget.6154. PubMed PMID: 26497683; PubMed Central PMCID: PMC4747186.

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