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MedKoo Cat#: 527076 | Name: 5-Fluoroorotic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

5-Fluoroorotic acid is an inhibitor of thymidylate synthase.

Chemical Structure

5-Fluoroorotic acid
5-Fluoroorotic acid
CAS#703-95-7

Theoretical Analysis

MedKoo Cat#: 527076

Name: 5-Fluoroorotic acid

CAS#: 703-95-7

Chemical Formula: C5H3FN2O4

Exact Mass: 174.0077

Molecular Weight: 174.09

Elemental Analysis: C, 34.50; H, 1.74; F, 10.91; N, 16.09; O, 36.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
5-Fluoroorotic acid
IUPAC/Chemical Name
5-Fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
InChi Key
SEHFUALWMUWDKS-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12)
SMILES Code
O=C(C(N1)=C(F)C(NC1=O)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 174.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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A Highly Thermostable Kanamycin Resistance Marker Expands the Tool Kit for Genetic Manipulation of Caldicellulosiruptor bescii. Appl Environ Microbiol. 2016 Jun 30;82(14):4421-8. doi: 10.1128/AEM.00570-16. Print 2016 Jul 15. PubMed PMID: 27208106; PubMed Central PMCID: PMC4959222. 11: Rugbjerg P, Genee HJ, Jensen K, Sarup-Lytzen K, Sommer MO. Molecular Buffers Permit Sensitivity Tuning and Inversion of Riboswitch Signals. ACS Synth Biol. 2016 Jul 15;5(7):632-8. doi: 10.1021/acssynbio.5b00213. Epub 2016 May 3. PubMed PMID: 27138234; PubMed Central PMCID: PMC4949582. 12: Zhang C, She Q, Bi H, Whitaker RJ. The apt/6-Methylpurine Counterselection System and Its Applications in Genetic Studies of the Hyperthermophilic Archaeon Sulfolobus islandicus. Appl Environ Microbiol. 2016 May 2;82(10):3070-81. doi: 10.1128/AEM.00455-16. Print 2016 May 15. PubMed PMID: 26969706; PubMed Central PMCID: PMC4959068. 13: Kurniyati K, Li C. pyrF as a Counterselectable Marker for Unmarked Genetic Manipulations in Treponema denticola. Appl Environ Microbiol. 2015 Dec 18;82(4):1346-52. doi: 10.1128/AEM.03704-15. PubMed PMID: 26682856; PubMed Central PMCID: PMC4751821. 14: Iwakuma H, Koyama Y, Miyachi A, Nasukawa M, Matsumoto H, Yano S, Ogihara J, Kasumi T. Generation of a glucose de-repressed mutant of Trichoderma reesei using disparity mutagenesis. Biosci Biotechnol Biochem. 2016;80(3):486-92. doi: 10.1080/09168451.2015.1104236. Epub 2015 Nov 5. PubMed PMID: 26540299. 15: Huang YW, Chang YC, Diaz-Avalos R, King CY. W8, a new Sup35 prion strain, transmits distinctive information with a conserved assembly scheme. Prion. 2015;9(3):207-27. doi: 10.1080/19336896.2015.1039217. PubMed PMID: 26038983; PubMed Central PMCID: PMC4601305. 16: de Medeiros AS, Hoffman CS. A yeast-based high-throughput screen for modulators of phosphodiesterase activity. 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