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MedKoo Cat#: 527062 | Name: Milrinone Lactate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Milrinone Lactate is a positive inotropic cardiotonic agent with vasodilator properties, inhibiting cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle.

Chemical Structure

Milrinone Lactate
Milrinone Lactate
CAS#100286-97-3

Theoretical Analysis

MedKoo Cat#: 527062

Name: Milrinone Lactate

CAS#: 100286-97-3

Chemical Formula: C15H15N3O4

Exact Mass: 301.1063

Molecular Weight: 301.30

Elemental Analysis: C, 59.80; H, 5.02; N, 13.95; O, 21.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Milrinone Lactate
IUPAC/Chemical Name
6-Methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile Lactate
InChi Key
VWUPWEAFIOQCGF-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H9N3O.C3H6O3/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8;1-2(4)3(5)6/h2-6H,1H3,(H,15,16);2,4H,1H3,(H,5,6)
SMILES Code
N#CC1=CC(C2=CC=NC=C2)=C(C)NC1=O.OC(C)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 301.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dünnes S, Voussen B, Aue A, Groneberg K, Nikolaev V, Groneberg D, Friebe A. Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase. Pflugers Arch. 2018 Jan 2. doi: 10.1007/s00424-017-2106-8. [Epub ahead of print] PubMed PMID: 29294149. 2: Mehanna OM, El Askary A, Al-Shehri S, El-Esawy B. Effect of phosphodiesterase inhibitors on renal functions and oxidant/antioxidant parameters in streptozocin-induced diabetic rats. Arch Physiol Biochem. 2017 Dec 22:1-6. doi: 10.1080/13813455.2017.1419267. [Epub ahead of print] PubMed PMID: 29271249. 3: Parker WF, Garrity ER Jr, Fedson S, Churpek MM. Trends in the Use of Inotropes to List Adult Heart Transplant Candidates at Status 1A. Circ Heart Fail. 2017 Dec;10(12). pii: e004483. doi: 10.1161/CIRCHEARTFAILURE.117.004483. PubMed PMID: 29246896; PubMed Central PMCID: PMC5739062. 4: Nwaejike N, Son AY, Patel CB, Schroder JN, Milano CA, Daneshmand MA. The Axillary Intra-Aortic Balloon Pump as a Bridge to Recovery Allows Early Ambulation in Long-Term Use: Case Series and Literature Review. Innovations (Phila). 2017 Nov/Dec;12(6):472-478. doi: 10.1097/IMI.0000000000000432. PubMed PMID: 29232299. 5: Lakshminrusimha S, Keszler M, Kirpalani H, Van Meurs K, Chess P, Ambalavanan N, Yoder B, Fraga MV, Hedrick H, Lally KP, Nelin L, Cotten M, Klein J, Guilford S, Williams A, Chaudhary A, Gantz M, Gabrio J, Chowdhury D, Zaterka-Baxter K, Das A, Higgins RD. Milrinone in congenital diaphragmatic hernia - a randomized pilot trial: study protocol, review of literature and survey of current practices. Matern Health Neonatol Perinatol. 2017 Nov 27;3:27. doi: 10.1186/s40748-017-0066-9. eCollection 2017. Review. PubMed PMID: 29209510; PubMed Central PMCID: PMC5704584. 6: Roof SR, Ueyama Y, Mazhari R, Hamlin RL, Hartman JC, Ziolo MT, Reardon JE, Del Rio CL. CXL-1020, a Novel Nitroxyl (HNO) Prodrug, Is More Effective than Milrinone in Models of Diastolic Dysfunction-A Cardiovascular Therapeutic: An Efficacy and Safety Study in the Rat. Front Physiol. 2017 Nov 10;8:894. doi: 10.3389/fphys.2017.00894. eCollection 2017. PubMed PMID: 29209225; PubMed Central PMCID: PMC5701606. 7: Dall'Acqua PC, Leão BCDS, Rocha-Frigoni NAS, Gottardi FP, Mingoti GZ. Delaying meiotic resumption during transportation of bovine cumulus-oocyte complexes: effects on development, apoptosis and caspases activity of in vitro-produced embryos. Zygote. 2017 Dec;25(6):740-750. doi: 10.1017/S0967199417000636. Epub 2017 Nov 27. PubMed PMID: 29173235. 8: Clark BC, Berger JT, Berul CI, Jonas RA, Kaltman JR, Lapsa J, Nath DS, Sherwin ED, Sinha P, Zurakowski D, Moak JP. Risk Factors for Development of Ectopic Atrial Tachycardia in Post-operative Congenital Heart Disease. Pediatr Cardiol. 2017 Nov 17. doi: 10.1007/s00246-017-1773-8. [Epub ahead of print] PubMed PMID: 29147786. 9: Dasgupta S, Qasim A, Aly AM, Jain SK. Mother With Diabetes Mellitus and Infant With Hypertrophic Obstructive Cardiomyopathy: Milrinone Precluded Need for Extracorporeal Membrane Oxygenation. Circ Cardiovasc Imaging. 2017 Nov;10(11). pii: e006809. doi: 10.1161/CIRCIMAGING.117.006809. PubMed PMID: 29133479. 10: Donaldson C, O'Neill AH, Slater LA, Chong W, Lai LT, Chandra RV. Feasibility of Real-Time Angiographic Perfusion Imaging in the Treatment of Cerebral Vasospasm. Interv Neurol. 2017 Oct;6(3-4):163-169. doi: 10.1159/000468157. Epub 2017 Apr 20. PubMed PMID: 29118793; PubMed Central PMCID: PMC5662991. 11: Roeleveld PP, de Klerk JCA. The Perspective of the Intensivist on Inotropes and Postoperative Care Following Pediatric Heart Surgery: An International Survey and Systematic Review of the Literature. World J Pediatr Congenit Heart Surg. 2017 Jan 1:2150135117731725. doi: 10.1177/2150135117731725. [Epub ahead of print] PubMed PMID: 29092664. 12: Chong LYZ, Satya K, Kim B, Berkowitz R. Milrinone Dosing and a Culture of Caution in Clinical Practice. Cardiol Rev. 2018 Jan/Feb;26(1):35-42. doi: 10.1097/CRD.0000000000000165. PubMed PMID: 29045285. 13: Malotte K, Saguros A, Groninger H. Continuous Cardiac Inotropes in Patients With End-Stage Heart Failure: An Evolving Experience. J Pain Symptom Manage. 2018 Jan;55(1):159-163. doi: 10.1016/j.jpainsymman.2017.09.026. Epub 2017 Oct 10. PubMed PMID: 29030210. 14: Lane SIR, Jones KT. Chromosome biorientation and APC activity remain uncoupled in oocytes with reduced volume. J Cell Biol. 2017 Dec 4;216(12):3949-3957. doi: 10.1083/jcb.201606134. Epub 2017 Oct 4. PubMed PMID: 28978643; PubMed Central PMCID: PMC5716262. 15: Yan Y, Jiang W, Liu J, Xu W, Qian H. Expression of Recombinant Phosphodiesterases 3A and 3B Using Baculovirus Expression System. Iran J Biotechnol. 2016 Dec;14(4):236-242. doi: 10.15171/ijb.1400. PubMed PMID: 28959341; PubMed Central PMCID: PMC5434993. 16: Duman E, Karakoç F, Pinar HU, Dogan R, Fırat A, Yıldırım E. Higher dose intra-arterial milrinone and intra-arterial combined milrinone-nimodipine infusion as a rescue therapy for refractory cerebral vasospasm. Interv Neuroradiol. 2017 Dec;23(6):636-643. doi: 10.1177/1591019917732288. Epub 2017 Sep 28. PubMed PMID: 28956512. 17: Ergenekon E, Rojas-Anaya H, Bravo MC, Kotidis C, Mahoney L, Rabe H. Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data. Curr Pharm Des. 2017 Sep 18. doi: 10.2174/1381612823666170918122755. [Epub ahead of print] PubMed PMID: 28925895. 18: Touchan J, Guglin M. Temporary Mechanical Circulatory Support for Cardiogenic Shock. Curr Treat Options Cardiovasc Med. 2017 Sep 14;19(10):77. doi: 10.1007/s11936-017-0576-9. Review. PubMed PMID: 28913740. 19: El-Nawawy AA, Abdelmohsen AM, Hassouna HM. Role of echocardiography in reducing shock reversal time in pediatric septic shock: a randomized controlled trial. J Pediatr (Rio J). 2017 Sep 3. pii: S0021-7557(16)30268-6. doi: 10.1016/j.jped.2017.02.005. [Epub ahead of print] PubMed PMID: 28873333. 20: Laneuville M, Ding J, Shamy M, Lum C, Dowlatshahi D. Intra-arterial milrinone may differentiate fulminant RCVS from vasculitis. Neurology. 2017 Sep 5;89(10):1093-1094. doi: 10.1212/WNL.0000000000004337. PubMed PMID: 28871063.