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MedKoo Cat#: 528055 | Name: Spongouridine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Spongouridine is a deamination metabolite of Cytarabine (GLXC-07791).

Chemical Structure

Spongouridine
Spongouridine
CAS#3083-77-0

Theoretical Analysis

MedKoo Cat#: 528055

Name: Spongouridine

CAS#: 3083-77-0

Chemical Formula: C9H12N2O6

Exact Mass: 244.0695

Molecular Weight: 244.20

Elemental Analysis: C, 44.27; H, 4.95; N, 11.47; O, 39.31

Price and Availability

Size Price Availability Quantity
1g USD 200.00 2 weeks
5g USD 350.00 2 weeks
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Related CAS #
No Data
Synonym
Spongouridine
IUPAC/Chemical Name
1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
InChi Key
DRTQHJPVMGBUCF-CCXZUQQUSA-N
InChi Code
InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1
SMILES Code
O=C1NC(C=CN1[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Spongouridine is an inactive metabolite of cytarabine. Spongouridine is formed when cytarabine undergoes deamination by cytidine deaminase.
In vitro activity:
To be determined
In vivo activity:
To be determined
Solvent mg/mL mM comments
Solubility
DMSO 50.0 204.75
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 244.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
To be determined
In vitro protocol:
To be determined
In vivo protocol:
To be determined
1: Bertin MJ, Schwartz SL, Lee J, Korobeynikov A, Dorrestein PC, Gerwick L, Gerwick WH. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. J Nat Prod. 2015 Mar 27;78(3):493-9. doi: 10.1021/np5009762. Epub 2015 Feb 10. PubMed PMID: 25668560; PubMed Central PMCID: PMC5065018. 2: Yoshikawa T, Kimura S, Hatano T, Okamoto K, Hayatsu H, Arimoto-Kobayashi S. Pseudouridine, an antimutagenic substance in beer towards N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Food Chem Toxicol. 2002 Aug;40(8):1165-70. PubMed PMID: 12067579. 3: Codington JF, Cushley RJ, Fox JJ. Nucleosides. XLVI. Selectively methylated derivatives of spongouridine. J Org Chem. 1968 Jan;33(1):466-8. PubMed PMID: 5634898.