MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 527051 | Name: Dropropizine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dropropizine is an oral non-opioid anti-tussive agent for treatment of cough.

Chemical Structure

Dropropizine
Dropropizine
CAS#17692-31-8 (free base)

Theoretical Analysis

MedKoo Cat#: 527051

Name: Dropropizine

CAS#: 17692-31-8 (free base)

Chemical Formula: C13H20N2O2

Exact Mass: 236.1525

Molecular Weight: 236.32

Elemental Analysis: C, 66.07; H, 8.53; N, 11.85; O, 13.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
857188-77-3 (HCl) 17692-31-8 (free base)
Synonym
Dropropizine
IUPAC/Chemical Name
3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
InChi Key
PTVWPYVOOKLBCG-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
SMILES Code
OCC(O)CN1CCN(C2=CC=CC=C2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 236.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mannini C, Lavorini F, Zanasi A, Saibene F, Lanata L, Fontana G. A Randomized Clinical Trial Comparing the Effects of Antitussive Agents on Respiratory Center Output in Patients With Chronic Cough. Chest. 2017 Jun;151(6):1288-1294. doi: 10.1016/j.chest.2017.02.001. Epub 2017 Feb 10. PubMed PMID: 28192113. 2: Clay E, Patacchini R, Trevisani M, Preti D, Branà MP, Spina D, Page C. Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs. J Pharmacol Exp Ther. 2016 Apr;357(1):73-83. doi: 10.1124/jpet.115.230227. Epub 2016 Feb 2. PubMed PMID: 26837703; PubMed Central PMCID: PMC4977573. 3: Miceli Sopo S, Greco M, Monaco S, Varrasi G, Di Lorenzo G, Simeone G; Milk Honey Study (M&HS) Group. Effect of multiple honey doses on non-specific acute cough in children. An open randomised study and literature review. Allergol Immunopathol (Madr). 2015 Sep-Oct;43(5):449-55. doi: 10.1016/j.aller.2014.06.002. Epub 2014 Sep 6. PubMed PMID: 25201759. 4: Luo YL, Li PB, Zhang CC, Zheng YF, Wang S, Nie YC, Zhang KJ, Su WW. Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure. Inflamm Res. 2013 Dec;62(12):1053-61. doi: 10.1007/s00011-013-0664-6. Epub 2013 Oct 2. PubMed PMID: 24085318. 5: Kumar PA, Raju TV, Thirupathi D, Kumar R, Shree J. Development and Validation of a Stability-Indicating LC-Method for the Simultaneous Estimation of Levodropropizine, Chloropheniramine, Methylparaben, Propylparaben, and Levodropropizine Impurities. Sci Pharm. 2013 Jan-Mar;81(1):139-50. doi: 10.3797/scipharm.1210-18. Epub 2012 Nov 17. PubMed PMID: 23641334; PubMed Central PMCID: PMC3617657. 6: Cao QR, Piao YN, Choi JS, Liu Y, Yang M, Cui JH. Design, in vitro release characterization and pharmacokinetics of novel controlled release pellets containing levodropropizine. Pharm Dev Technol. 2014 May;19(3):296-303. doi: 10.3109/10837450.2013.778871. Epub 2013 Mar 19. PubMed PMID: 23509871. 7: Jang JW, Seo JH, Jo MH, Lee YJ, Cho YW, Yim SV, Lee KT. Relative bioavailability of levodropropizine 60 mg capsule and syrup formulations in healthy male Korean volunteers: a singledose, randomized-sequence, open-label, two-way crossover study. Int J Clin Pharmacol Ther. 2013 Feb;51(2):152-60. PubMed PMID: 23351597. 8: Park KH, Yun IS, Choi SY, Lee JH, Hong CS, Park JW. A case of immunoglobulin E mediated anaphylaxis to levodropropizine. Yonsei Med J. 2013 Jan 1;54(1):262-4. doi: 10.3349/ymj.2013.54.1.262. PubMed PMID: 23225830; PubMed Central PMCID: PMC3521276. 9: De Blasio F, Dicpinigaitis PV, De Danieli G, Lanata L, Zanasi A. Efficacy of levodropropizine in pediatric cough. Pulm Pharmacol Ther. 2012 Oct;25(5):337-42. doi: 10.1016/j.pupt.2012.05.010. Epub 2012 Jul 4. Review. PubMed PMID: 22771902. 10: Schildmann EK, Rémi C, Bausewein C. Levodropropizine in the management of cough associated with cancer or nonmalignant chronic disease--a systematic review. J Pain Palliat Care Pharmacother. 2011;25(3):209-18. doi: 10.3109/15360288.2011.583979. Epub 2011 Aug 1. Review. PubMed PMID: 21806417. 11: Abdallah OM. Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms. Int J Anal Chem. 2010;2010:704564. doi: 10.1155/2010/704564. Epub 2010 Jun 29. PubMed PMID: 20671996; PubMed Central PMCID: PMC2910454. 12: Hur GY, Lee SY, Shim JJ, Park HS, Kang KH. An anaphylactic reaction caused by levodropropizine. Allergy. 2010 Mar;65(3):409-10. doi: 10.1111/j.1398-9995.2009.02185.x. Epub 2009 Oct 1. PubMed PMID: 19796190. 13: Sutovska M, Franova S, Sutovsky J. The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways. Bratisl Lek Listy. 2009;110(5):269-75. PubMed PMID: 19507659. 14: Yan L, Li T, Zhang R, Xu X, Zheng P. HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs. Arch Pharm Res. 2006 Jun;29(6):514-9. PubMed PMID: 16833021. 15: Zhao LM, Zhao L, Sun YX, Qiu F, Guo SB. [Determination of levodropropizine and its pharmacokinetics in human plasma using LC/MS/MS]. Yao Xue Xue Bao. 2004 Dec;39(12):993-6. Chinese. PubMed PMID: 15813028. 16: Tang Y, Zhao L, Wang Y, Fawcett JP, Gu J. Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 May 5;819(1):185-9. PubMed PMID: 15797538. 17: Aliprandi P, Castelli C, Bernorio S, Dell'Abate E, Carrara M. Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents. Drugs Exp Clin Res. 2004;30(4):133-41. PubMed PMID: 15553659. 18: Franova S, Nosalova G. Antitussive effect of diltiazem in experimental conditions. Bratisl Lek Listy. 2004;105(5-6):203-6. PubMed PMID: 15535110. 19: Staack RF, Theobald DS, Maurer HH. Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry. Ther Drug Monit. 2004 Aug;26(4):441-9. PubMed PMID: 15257075. 20: Staack RF, Maurer HH. Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Dec 25;798(2):333-42. PubMed PMID: 14643514.