SR31527 is a novel inhibitor of kinesin-like protein KIFC1. SR31527 inhibited KIFC1 by binding directly to an allosteric site of KIFC1 without involving MTs. Moreover, SR31527 prevented bipolar clustering of extra centrosomes in TNBC cells and significantly reduced TNBC cell colony formation and viability, and was less cytotoxic to normal fibroblasts. SR31527 provides a valuable tool for studying the biological function of KIFC1 and serves as a potential lead for the development of novel therapeutic agents for breast cancer treatment.
MedKoo Cat#: 527023
Name: SR31527
CAS#: 311814-78-5 (chloride)
Chemical Formula: C15H14ClN3OS
Exact Mass: 319.0546
Molecular Weight: 319.81
Elemental Analysis: C, 56.34; H, 4.41; Cl, 11.08; N, 13.14; O, 5.00; S, 10.02
The following data is based on the product molecular weight 319.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
