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MedKoo Cat#: 526495 | Name: Cinitapride Tartrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cinitapride is a gastroprokinetic agent and medication prescribed to treat conditions caused by an overactive digestive tract. It slows the actions of the muscles to reduce the symptoms of conditions such as acid reflux, ulcer dyspepsia, and delayed gastric emptying. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.

Chemical Structure

Cinitapride Tartrate
Cinitapride Tartrate
CAS#1207859-16-2 (tartrate)

Theoretical Analysis

MedKoo Cat#: 526495

Name: Cinitapride Tartrate

CAS#: 1207859-16-2 (tartrate)

Chemical Formula: C25H36N4O10

Exact Mass: 552.2400

Molecular Weight: 552.58

Elemental Analysis: C, 54.34; H, 6.57; N, 10.14; O, 28.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
66564-14-5 (free base) 1207859-16-2 (tartrate) 67135-13-1 (H tartrate)
Synonym
Cinitapride Tartrate; AS-17177; AS 17177; AS17177;
IUPAC/Chemical Name
4-Amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide Tartrate
InChi Key
HVANMRCHFMTSEG-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H30N4O4.C4H6O6/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15;5-1(3(7)8)2(6)4(9)10/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26);1-2,5-6H,(H,7,8)(H,9,10)
SMILES Code
O=C(NC1CCN(CC2CC=CCC2)CC1)C3=CC([N+]([O-])=O)=C(N)C=C3OCC.OC(C(C(O)=O)O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 552.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rehman A, Beg AE, Bushra R, Ashfaq M, Zafar F, Ali H, Rizvi M. Development and validation of stability indicating assay method for cinitapride in bulk & tablets. Pak J Pharm Sci. 2017 Nov;30(6(Supplementary)):2341-2347. PubMed PMID: 29188767. 2: de Souza A, de Souza RJ. Parkinsonism and Tremor Complicating Long-term Cinitapride Use. Ann Indian Acad Neurol. 2017 Oct-Dec;20(4):435-436. doi: 10.4103/aian.AIAN_225_17. PubMed PMID: 29184356. 3: Marcelín-Jiménez G, Contreras L, Esquivel J, Ávila Ó, Batista D, Ángeles AP, García-González A. Development of an UPLC-MS/MS micromethod for quantitation of cinitapride in plasma and its application in a pharmacokinetic interaction trial. Bioanalysis. 2017 Mar;9(6):569-579. doi: 10.4155/bio-2016-0210. Epub 2017 Feb 22. PubMed PMID: 28225297. 4: Du Y, Su T, Song X, Gao J, Zou D, Zuo C, Xie W, Wang B, Zhang Z, Xu J, Tian D, Luo H, Zhang Z, Wang S, Chen J, Guo J, Gong L, Ding Y, Li Z. Efficacy and safety of cinitapride in the treatment of mild to moderate postprandial distress syndrome-predominant functional dyspepsia. J Clin Gastroenterol. 2014 Apr;48(4):328-35. doi: 10.1097/MCG.0000000000000033. PubMed PMID: 24440931. 5: Baqai MT, Malik MN, Ziauddin F. Efficacy and safety of cinitapride in functional dyspepsia. J Pak Med Assoc. 2013 Jun;63(6):747-51. PubMed PMID: 23901678. 6: Marquez H, Albertí J, Salvà M, Saurina J, Sentellas S. Characterization of in vitro metabolic profiles of cinitapride obtained with liver microsomes of humans and various mammal species using UHPLC and chemometric methods for data analysis. Anal Bioanal Chem. 2012 May;403(4):909-16. doi: 10.1007/s00216-012-5795-z. Epub 2012 Feb 24. PubMed PMID: 22362276. 7: Castro FJ, Saavedra J, López F, Herrera S, Bragulat E. [Acute cinitapride poisoning]. Gastroenterol Hepatol. 2011 Nov;34(9):662-3. doi: 10.1016/j.gastrohep.2011.04.008. Epub 2011 Jun 24. Spanish. PubMed PMID: 21704434. 8: Marquez H, Albertí J, Salvà M, Saurina J, Sentellas S. Development of a UHPLC method for the assessment of the metabolic profile of cinitapride. J Sep Sci. 2011 Dec;34(24):3502-8. doi: 10.1002/jssc.201100073. Epub 2011 Jun 22. PubMed PMID: 21695682. 9: Mearín F, Plazas MJ, Mas M, Heras J. [Cardiac safety of cinitapride]. Gastroenterol Hepatol. 2010 Oct;33(8):614. doi: 10.1016/j.gastrohep.2010.07.004. Epub 2010 Sep 17. Spanish. PubMed PMID: 20850201. 10: Chiner E, Sancho-Chust JN, Llombart M, Camarasa A, Senent C, Mediero G, Gómez-Merino E. Sleep-related painful erection in a 50-year-old man successfully treated with cinitapride. J Sex Med. 2010 Nov;7(11):3789-92. doi: 10.1111/j.1743-6109.2010.01939.x. PubMed PMID: 20584109. 11: González Gutiérrez ML, Rubio Pérez M, Vázquez Cortés S, Martínez González de Lema B. Cinitapride-induced exanthema. J Investig Allergol Clin Immunol. 2010;20(2):174. PubMed PMID: 20461977. 12: Portincasa P, Mearin F, Robert M, Plazas MJ, Mas M, Heras J. [Efficacy and tolerability of cinitapride in the treatment of functional dyspepsia and delayed gastric emptying]. Gastroenterol Hepatol. 2009 Dec;32(10):669-76. doi: 10.1016/j.gastrohep.2009.06.013. Epub 2009 Oct 9. Spanish. Erratum in: Gastroenterol Hepatol. 2010 Apr;33(4):345. PubMed PMID: 19819042. 13: Fernández Tagarro EJ, de Gracia Núñez R, Sánchez Villanueva RJ, Riñón Aguilar C, Selgas Gutiérrez R. [Prokinetic agents as a cause of granulomatous interstitial nephritis]. Gastroenterol Hepatol. 2007 Dec;30(10):583-4. Spanish. PubMed PMID: 18028853. 14: Robert M, Salvà M, Segarra R, Pavesi M, Esbri R, Roberts D, Golor G. The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole. Drug Metab Dispos. 2007 Jul;35(7):1149-56. Epub 2007 Apr 16. PubMed PMID: 17437965. 15: Martínez de Juan F, Martínez-Lapiedra C, Picazo V. [Phytobezoar dissolution with Coca-Cola]. Gastroenterol Hepatol. 2006 May;29(5):291-3. Spanish. PubMed PMID: 16733034. 16: Rivera P, Ferrer L, Tuset JA, Pamos S, López Mut J, Luján M, Tomé A, Medina E. [Non-aneurysmatic aortic dysphagia]. Gastroenterol Hepatol. 1999 Aug-Sep;22(7):345-8. Spanish. PubMed PMID: 10535207. 17: Alarcón de la Lastra C, La Casa C, Martin MJ, Motilva V. Effects of cinitapride on gastric ulceration and secretion in rats. Inflamm Res. 1998 Mar;47(3):131-6. PubMed PMID: 9562338. 18: Alarcón-de-la-Lastra Romero C, López A, Martín MJ, la Casa C, Motilva V. Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds. Pharmacology. 1997 Apr;54(4):193-202. PubMed PMID: 9211565. 19: Blanco M, Coello J, González F, Iturriaga H, Maspoch S. Spectrophotometric analysis of a pharmaceutical preparation by principal component regression. J Pharm Sci. 1993 Aug;82(8):834-7. PubMed PMID: 8377123. 20: Mora F, Añón R, Liceras V, Moreno-Osset E, Mínguez M, Benages A. [Metoclopramide versus cinitapride in the treatment of functional dyspepsia]. An Med Interna. 1993 Jul;10(7):323-6. Spanish. PubMed PMID: 8218764.