MedKoo Cat#: 526485 | Name: IUN38767

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IUN38767, also known as FQ is a novel reversible mixed-type tyrosinase inhibitor. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

IUN38767
IUN38767
CAS#190838-76-7

Theoretical Analysis

MedKoo Cat#: 526485

Name: IUN38767

CAS#: 190838-76-7

Chemical Formula: C14H9FN2O

Exact Mass: 240.0700

Molecular Weight: 240.24

Elemental Analysis: C, 69.99; H, 3.78; F, 7.91; N, 11.66; O, 6.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
FQ; IUN38767; IUN 38767; IUN-38767;
IUPAC/Chemical Name
2-(4-Fluorophenyl)-quinazolin-4(3H)-one
InChi Key
IXMXCFSRQIHRHB-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H9FN2O/c15-10-7-5-9(6-8-10)13-16-12-4-2-1-3-11(12)14(18)17-13/h1-8H,(H,16,17,18)
SMILES Code
O=C1NC(C2=CC=C(F)C=C2)=NC3=C1C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 240.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Luiz GO, Benevides RS, Santos FGS, Espinel YAV, Mayer Alegre TP, Wiederhecker GS. Efficient anchor loss suppression in coupled near-field optomechanical resonators. Opt Express. 2017 Dec 11;25(25):31347-31361. doi: 10.1364/OE.25.031347. PubMed PMID: 29245810. 2: Li Q, Li X, Deng CL. Induction of proliferation and activation of rat hepatic stellate cells via high glucose and high insulin. Eur Rev Med Pharmacol Sci. 2017 Dec;21(23):5420-5429. doi: 10.26355/eurrev_201712_13930. PubMed PMID: 29243785. 3: Arcuri L, Novello S, Frassineti M, Mercatelli D, Pisanò CA, Morella I, Fasano S, Journigan BV, Meyer ME, Polgar WE, Brambilla R, Zaveri NT, Morari M. Antiparkinsonian and antidyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists. Br J Pharmacol. 2017 Dec 12. doi: 10.1111/bph.14123. [Epub ahead of print] PubMed PMID: 29232769. 4: Zaveri NT, Marquez PV, Meyer ME, Polgar WE, Hamid A, Lutfy K. A novel and selective nociceptin receptor (NOP) agonist (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol (AT-312) decreases acquisition of ethanol-induced conditioned place preference in mice. Alcohol Clin Exp Res. 2017 Dec 7. doi: 10.1111/acer.13575. [Epub ahead of print] PubMed PMID: 29215139. 5: Wu J, Lan F, Lu Y, He Q, Li B. Molecular Characteristics of ST1193 Clone among Phylogenetic Group B2 Non-ST131 Fluoroquinolone-Resistant Escherichia coli. Front Microbiol. 2017 Nov 21;8:2294. doi: 10.3389/fmicb.2017.02294. eCollection 2017. PubMed PMID: 29209300; PubMed Central PMCID: PMC5702334. 6: Salinas G, Comini MA. Alternative Thiol-Based Redox Systems. Antioxid Redox Signal. 2017 Dec 5. doi: 10.1089/ars.2017.7464. [Epub ahead of print] PubMed PMID: 29207877. 7: Vidal L, Antúnez L, Giménez A, Medina K, Boido E, Ares G. Sensory characterization of the astringency of commercial Uruguayan Tannat wines. Food Res Int. 2017 Dec;102:425-434. doi: 10.1016/j.foodres.2017.09.022. Epub 2017 Sep 9. PubMed PMID: 29195968. 8: Antúnez L, Giménez A, Ares G. A consumer-based approach to salt reduction: Case study with bread. Food Res Int. 2016 Dec;90:66-72. doi: 10.1016/j.foodres.2016.10.015. Epub 2016 Oct 20. PubMed PMID: 29195892. 9: Rising R, Foerster T, Arad AD, Albu J, Pi-Sunyer X. Validation of whole room indirect calorimeters: refinement of current methodologies. Physiol Rep. 2017 Nov;5(22). pii: e13521. doi: 10.14814/phy2.13521. PubMed PMID: 29180485; PubMed Central PMCID: PMC5704087. 10: Garmendia G, Umpierrez-Failache M, Ward TJ, Vero S. Development of a PCR-RFLP method based on the transcription elongation factor 1-α gene to differentiate Fusarium graminearum from other species within the Fusarium graminearum species complex. Food Microbiol. 2018 Apr;70:28-32. doi: 10.1016/j.fm.2017.08.020. Epub 2017 Aug 28. PubMed PMID: 29173636. 11: Okaikue-Woodi FEK, Kelch SE, Schmidt MP, Enid Martinez C, Youngman RE, Aristilde L. Structures and mechanisms in clay nanopore trapping of structurally-different fluoroquinolone antimicrobials. J Colloid Interface Sci. 2017 Nov 8;513:367-378. doi: 10.1016/j.jcis.2017.11.020. [Epub ahead of print] PubMed PMID: 29169026. 12: Kondratskyi A, Kondratska K, Vanden Abeele F, Gordienko D, Dubois C, Toillon RA, Slomianny C, Lemière S, Delcourt P, Dewailly E, Skryma R, Biot C, Prevarskaya N. Ferroquine, the next generation antimalarial drug, has antitumor activity. Sci Rep. 2017 Nov 21;7(1):15896. doi: 10.1038/s41598-017-16154-2. PubMed PMID: 29162859; PubMed Central PMCID: PMC5698296. 13: Farid S, Mahmood M, Abu Saleh OM, Hamadah A, Nasr SH, Garrigos ZE, Leung N, Sohail MR. Clinical Manifestations and Outcomes of Fluoroquinolone-Related Acute Interstitial Nephritis. Mayo Clin Proc. 2017 Nov 17. pii: S0025-6196(17)30695-X. doi: 10.1016/j.mayocp.2017.08.024. [Epub ahead of print] PubMed PMID: 29157532. 14: Tzschentke TM, Rutten K. Mu-opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptor activation both contribute to the discriminative stimulus properties of cebranopadol in the rat. Neuropharmacology. 2018 Feb;129:100-108. doi: 10.1016/j.neuropharm.2017.11.026. Epub 2017 Nov 16. PubMed PMID: 29155273. 15: Yaghoubi S, Ranjbar R, Soltan Dallal MM, Shirazi MH, Sharifi-Yazdi MK. The Frequency of Mutations in Quinolone Resistance-Determining Regions and Plasmid-Mediated Quinolone Resistance in Shigella Isolates Recovered from Pediatric Patients in Tehran, Iran: An Overlooked Problem. Microb Drug Resist. 2017 Nov 17. doi: 10.1089/mdr.2017.0155. [Epub ahead of print] PubMed PMID: 29148915. 16: Yadav S, Goel N, Kumar V, Tikoo K, Singhal S. Removal of fluoroquinolone from aqueous solution using graphene oxide: experimental and computational elucidation. Environ Sci Pollut Res Int. 2017 Nov 16. doi: 10.1007/s11356-017-0596-8. [Epub ahead of print] PubMed PMID: 29147984. 17: Michalak K, Sobolewska-Włodarczyk A, Włodarczyk M, Sobolewska J, Woźniak P, Sobolewski B. Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications. Oxid Med Cell Longev. 2017;2017:8023935. doi: 10.1155/2017/8023935. Epub 2017 Sep 25. Review. PubMed PMID: 29147464; PubMed Central PMCID: PMC5632915. 18: Jesús F, Hladki R, Gérez N, Besil N, Niell S, Fernández G, Heinzen H, Cesio MV. Miniaturized QuEChERS based methodology for multiresidue determination of pesticides in odonate nymphs as ecosystem biomonitors. Talanta. 2018 Feb 1;178:410-418. doi: 10.1016/j.talanta.2017.09.014. Epub 2017 Sep 8. PubMed PMID: 29136841. 19: Takahara M, Wakabayashi R, Minamihata K, Goto M, Kamiya N. Primary Amine-Clustered DNA Aptamer for DNA-Protein Conjugation Catalyzed by Microbial Transglutaminase. Bioconjug Chem. 2017 Nov 20. doi: 10.1021/acs.bioconjchem.7b00594. [Epub ahead of print] PubMed PMID: 29131594. 20: Ingold M, Dapueto R, Victoria S, Galliusi G, Batthyàny C, Bollati-Fogolín M, Tejedor D, García-Tellado F, Padrón JM, Porcal W, López GV. A green multicomponent synthesis of tocopherol analogues with antiproliferative activities. Eur J Med Chem. 2017 Nov 3. pii: S0223-5234(17)30888-7. doi: 10.1016/j.ejmech.2017.11.003. [Epub ahead of print] PubMed PMID: 29129514.