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MedKoo Cat#: 561630 | Name: Diniconazole
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diniconazole is a fungicide. It is known as a plant hormone abscisic acid (ABA) catabolic inhibitor, and acts as a potent competitive inhibitor of recombinant Arabidopsis ABA 8'-hydroxylase, CYP707A3.

Chemical Structure

Diniconazole
Diniconazole
CAS#83657-24-3

Theoretical Analysis

MedKoo Cat#: 561630

Name: Diniconazole

CAS#: 83657-24-3

Chemical Formula: C15H17Cl2N3O

Exact Mass: 325.0749

Molecular Weight: 326.22

Elemental Analysis: C, 55.23; H, 5.25; Cl, 21.73; N, 12.88; O, 4.90

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 Weeks
250mg USD 450.00 2 Weeks
1g USD 950.00 2 weeks
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Related CAS #
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Synonym
Diniconazole; S-3308L; Spotless; Mixor; Ortho spotless; Sumi; Rac-diniconazole; S-3308; S3308; S 3308;
IUPAC/Chemical Name
(E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol
InChi Key
FBOUIAKEJMZPQG-AWNIVKPZSA-N
InChi Code
InChI=1S/C15H17Cl2N3O/c1-15(2,3)14(21)13(20-9-18-8-19-20)6-10-4-5-11(16)7-12(10)17/h4-9,14,21H,1-3H3/b13-6+
SMILES Code
CC(C)(C)C(O)/C(N1N=CN=C1)=C\C2=CC=C(Cl)C=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Diniconazole is a newly developed fungicide strongly inhibited lanosterol 14 alpha-demethylation catalyzed by a yeast cytochrome P-450.
In vitro activity:
Diniconazole treatment increased the ABA content in seeds by inhibiting ABA catabolism. Compared with untreated WR04-6 seeds, low concentrations of inhibitor (10 μM or 20 μM) had no significant effect on seed germination, but a relatively lower germination rate was observed with 30 μM diniconazole, suggesting that catabolism of ABA plays a role in seed germination (Fig. 1c). Reference: Sci Rep. 2021 Jun 18;11(1):12881. https://pubmed.ncbi.nlm.nih.gov/34145345/
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 100.0 306.54
Water 0.7 2.05
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 326.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Lang H, He Y, Zeng F, Xu F, Zhao M, Ma D. Comparative transcriptomic and physiological analyses of weedy rice and cultivated rice to identify vital differentially expressed genes and pathways regulating the ABA response. Sci Rep. 2021 Jun 18;11(1):12881. doi: 10.1038/s41598-021-92504-5. PMID: 34145345; PMCID: PMC8213743.
In vitro protocol:
1. Lang H, He Y, Zeng F, Xu F, Zhao M, Ma D. Comparative transcriptomic and physiological analyses of weedy rice and cultivated rice to identify vital differentially expressed genes and pathways regulating the ABA response. Sci Rep. 2021 Jun 18;11(1):12881. doi: 10.1038/s41598-021-92504-5. PMID: 34145345; PMCID: PMC8213743.
In vivo protocol:
TBD
1: Farajzadeh MA, Mohebbi A. Development of magnetic dispersive solid phase extraction using toner powder as an efficient and economic sorbent in combination with dispersive liquid-liquid microextraction for extraction of some widely used pesticides in fruit juices. J Chromatogr A. 2017 Nov 22. pii: S0021-9673(17)31736-3. doi: 10.1016/j.chroma.2017.11.048. [Epub ahead of print] PubMed PMID: 29174132. 2: Rodríguez-Cabo T, Rodríguez I, Ramil M, Cela R. Evaluation of the aqueous phototransformation routes of phenyl ethyl azolic fungicides by liquid chromatography accurate mass spectrometry. Sci Total Environ. 2018 Feb 15;615:942-954. doi: 10.1016/j.scitotenv.2017.10.003. Epub 2017 Oct 7. PubMed PMID: 29017135. 3: Asakura T, Kitamura M, Seki W, Iida T, Nakazato M, Yasuda K, Nemoto S. Determination of Diniconazole in Agricultural Products, Livestock and Marine Products by LC-MS/MS. Shokuhin Eiseigaku Zasshi. 2017;58(4):195-200. doi: 10.3358/shokueishi.58.195. Japanese. PubMed PMID: 28855474. 4: Qian H, Duan M, Sun X, Chi M, Zhao Y, Liang W, Du J, Huang J, Li B. The binding mechanism between azoles and FgCYP51B, sterol 14α-demethylase of Fusarium graminearum. Pest Manag Sci. 2017 Jul 18. doi: 10.1002/ps.4667. [Epub ahead of print] PubMed PMID: 28719051. 5: Ma S, Yuan X, Zhao P, Sun H, Ye X, Liang N, Zhao L. Trace determination of five triazole fungicide residues in traditional Chinese medicine samples by dispersive solid-phase extraction combined with ultrasound-assisted dispersive liquid-liquid microextraction and UHPLC-MS/MS. J Sep Sci. 2017 Aug;40(16):3257-3266. doi: 10.1002/jssc.201700250. Epub 2017 Jul 21. PubMed PMID: 28639734. 6: Gao P, Cui YL, Wu RL. Molecular dynamic modeling of CYP51B in complex with azole inhibitors. J Biomol Struct Dyn. 2017 May 28:1-9. doi: 10.1080/07391102.2017.1328315. [Epub ahead of print] PubMed PMID: 28504057. 7: Amjadi M, Jalili R. Molecularly imprinted mesoporous silica embedded with carbon dots and semiconductor quantum dots as a ratiometric fluorescent sensor for diniconazole. Biosens Bioelectron. 2017 Oct 15;96:121-126. doi: 10.1016/j.bios.2017.04.045. Epub 2017 Apr 28. PubMed PMID: 28477568. 8: AlJabr AM, Hussain A, Rizwan-Ul-Haq M, Al-Ayedh H. Toxicity of Plant Secondary Metabolites Modulating Detoxification Genes Expression for Natural Red Palm Weevil Pesticide Development. Molecules. 2017 Jan 20;22(1). pii: E169. doi: 10.3390/molecules22010169. PubMed PMID: 28117698. 9: Syromyatnikov MY, Kokina AV, Lopatin AV, Starkov AA, Popov VN. Evaluation of the toxicity of fungicides to flight muscle mitochondria of bumblebee (Bombus terrestris L.). Pestic Biochem Physiol. 2017 Jan;135:41-46. doi: 10.1016/j.pestbp.2016.06.007. Epub 2016 Jun 30. PubMed PMID: 28043329. 10: Wang Y, Zhu W, Wang D, Teng M, Yan J, Miao J, Zhou Z. (1)H NMR-based metabolomics analysis of adult zebrafish (Danio rerio) after exposure to diniconazole as well as its bioaccumulation behavior. Chemosphere. 2017 Feb;168:1571-1577. doi: 10.1016/j.chemosphere.2016.11.157. Epub 2016 Dec 1. PubMed PMID: 27938984. 11: Gallart-Mateu D, Armenta S, de la Guardia M. Indoor and outdoor determination of pesticides in air by ion mobility spectrometry. Talanta. 2016 Dec 1;161:632-639. doi: 10.1016/j.talanta.2016.09.020. Epub 2016 Sep 6. PubMed PMID: 27769458. 12: Tuzimski T, Rejczak T, Pieniążek D, Buszewicz G, Teresiński G. Comparison of SPE/d-SPE and QuEChERS-Based Extraction Procedures in Terms of Fungicide Residue Analysis in Wine Samples by HPLC-DAD and LC-QqQ-MS. J AOAC Int. 2016 Nov 1;99(6):1436-1443. doi: 10.5740/jaoacint.16-0277. Epub 2016 Sep 14. PubMed PMID: 27634101. 13: Su H, Lin Y, Wang Z, Wong YL, Chen X, Chan TW. Magnetic metal-organic framework-titanium dioxide nanocomposite as adsorbent in the magnetic solid-phase extraction of fungicides from environmental water samples. J Chromatogr A. 2016 Sep 30;1466:21-8. doi: 10.1016/j.chroma.2016.08.066. Epub 2016 Aug 30. PubMed PMID: 27592609. 14: Zendegi-Shiraz A, Sarafraz-Yazdi A, Es'haghi Z. Polyethylene glycol grafted flower-like cupric nano oxide for the hollow-fiber solid-phase microextraction of hexaconazole, penconazole, and diniconazole in vegetable samples. J Sep Sci. 2016 Aug;39(16):3137-44. doi: 10.1002/jssc.201600429. PubMed PMID: 27383849. 15: Liu J, Tong L, Li D, Meng W, Sun W, Zhao Y, Yu Z. Comparison of two extraction methods for the determination of 135 pesticides in Corydalis Rhizoma, Chuanxiong Rhizoma and Angelicae Sinensis Radix by liquid chromatography-triple quadrupole-mass spectrometry. Application to the roots and rhizomes of Chinese herbal medicines. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 1;1017-1018:233-40. doi: 10.1016/j.jchromb.2016.03.003. Epub 2016 Mar 7. PubMed PMID: 26990739. 16: Farajzadeh MA, Afshar Mogaddam MR. Acid-base reaction-based dispersive liquid-liquid microextraction method for extraction of three classes of pesticides from fruit juice samples. J Chromatogr A. 2016 Jan 29;1431:8-16. doi: 10.1016/j.chroma.2015.12.059. Epub 2015 Dec 24. Erratum in: J Chromatogr A. 2017 Nov 21;:. PubMed PMID: 26755415. 17: Xi T, Li J, Yan B, Yang M, Song J, Ma H. A new Co(II) complex of diniconazole: synthesis, crystal structure and antifungal activity. Acta Crystallogr C Struct Chem. 2015 Oct;71(Pt 10):889-93. doi: 10.1107/S2053229615016241. Epub 2015 Sep 18. PubMed PMID: 26422217. 18: Sheng E, Shi H, Zhou L, Hua X, Feng L, Yu T, Wang M. Dual-labeled time-resolved fluoroimmunoassay for simultaneous detection of clothianidin and diniconazole in agricultural samples. Food Chem. 2016 Feb 1;192:525-30. doi: 10.1016/j.foodchem.2015.07.023. Epub 2015 Jul 8. PubMed PMID: 26304380. 19: Farajzadeh MA, Feriduni B, Mogaddam MR. Determination of triazole pesticide residues in edible oils using air-assisted liquid-liquid microextraction followed by gas chromatography with flame ionization detection. J Sep Sci. 2015 Mar;38(6):1002-9. doi: 10.1002/jssc.201400818. Epub 2015 Feb 5. PubMed PMID: 25580590. 20: Xue J, Chen X, Jiang W, Liu F, Li H. Rapid and sensitive analysis of nine fungicide residues in chrysanthemum by matrix extraction-vortex-assisted dispersive liquid-liquid microextraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 15;975:9-17. doi: 10.1016/j.jchromb.2014.10.029. Epub 2014 Nov 1. PubMed PMID: 25462106.