Synonym
Lomapect; Libexin; HK 256; HK-256; HK256; Toparten; Prenoxdiazine hydrochloride;
IUPAC/Chemical Name
3-(2,2-diphenylethyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,4-oxadiazole hydrochloride
InChi Key
ONTOFAWPPHNLML-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H27N3O.ClH/c1-4-10-19(11-5-1)21(20-12-6-2-7-13-20)18-22-24-23(27-25-22)14-17-26-15-8-3-9-16-26;/h1-2,4-7,10-13,21H,3,8-9,14-18H2;1H
SMILES Code
[H]Cl.N1(CCC2=NC(CC(C3=CC=CC=C3)C4=CC=CC=C4)=NO2)CCCCC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
397.94
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Schweiger O. The role of Libexin combination in the symptomatic treatment of different pulmonary diseases. Ther Hung. 1984;32(2):85-6. PubMed PMID: 6546267.
2: Shul'gin AV, Abramova VG, Votchal OA. [Clinical evaluation of the antitussive action of libexin and baltix]. Ter Arkh. 1975;47(3):140-2. Russian. PubMed PMID: 779093.
3: Csürös L. Fifteen years of experience on the use of Libexin tablets. Ther Hung. 1989;37(1):50-4. Review. PubMed PMID: 2667194.
4: Rácz I, Plachy J, Gyarmati L. [Libexin metabolism]. Acta Pharm Hung. 1978;48 Suppl:11-3. Hungarian. PubMed PMID: 749516.
5: Gergely I. Libexin combinatum in the treatment of patients suffering from chronic respiratory tract diseases. Ther Hung. 1978;26(3):136-8. PubMed PMID: 725818.
6: Halmos T, Salamon F. Observations with Libexin-c in bronchopulmonary syndromes. Ther Hung. 1973;21(3-4):149-51. PubMed PMID: 4808355.
7: Balázs C, Szabó M, Szerze P, Leövey A. Effect of libexin combinatum (libexine and emetine) on phagocytosis by polymorphonuclear granulocytes and alveolar macrophages. Eur J Clin Pharmacol. 1977 Dec 16;12(5):345-8. PubMed PMID: 340236.
8: Hankovszky M, Károlyi A. [Study on the antitussive effect of Libexin in clinical practice]. Orv Hetil. 1966 Jul 24;107(30):1427-8. Hungarian. PubMed PMID: 5968420.
9: Bollabás B. Application of libexin in diseases of the respiratory tract. Ther Hung. 1968;16(1):38-41. PubMed PMID: 5655291.
10: Vas M, Kun A. A new antitussive (libexin) for geriatric use. Ther Hung. 1967;15(1):32-4. PubMed PMID: 5343252.
11: Rédey T, Skoda E. Clinical use of Libexin, a new peripheral antitussive. Ther Hung. 1967;15(3):117-9. PubMed PMID: 4866485.
12: Poórnénémeth M, Rácz I, Plachy J, Gyarmati L. [Microdetermination of Libexin in biological media. II. Fluorometric determination of Libexin]. Acta Pharm Hung. 1978 Nov;48(6):261-6. Hungarian. PubMed PMID: 716933.
13: Kiss J, Pongor F, Nagy M. Comparative investigation of Libexin and Hydrocodin. Ther Hung. 1968;16(2):79-82. PubMed PMID: 5666419.
14: Plachy J, Rácz I, Poórné NM, Gyarmati L. [Microdetermination of 3-(2,2-diphenylethyl)-5-(2-piperidine-ethyl)-1,2,4-oxadiazol (Libexin) in biological medium. I. Determination of Libexin by the ion-pair formation method]. Acta Pharm Hung. 1978 Sep;48(5):204-9. Hungarian. PubMed PMID: 707114.
15: Keszler P, Babanassi E. Libexin in pulmonary surgery. Ther Hung. 1968;16(3):130-2. PubMed PMID: 5726086.
16: Harsányi K, Tardos L, Fehér I, Nagy G. Pharmacologic, clinico-pharmacologic and clinical effects of Libexin. Boll Chim Farm. 1973 Oct;112(10):691-9. PubMed PMID: 4782264.
17: Pandula E, Harsányi K, Rácz I. [The mechanism of the solvolysis of 3-(2,2-diphenyl-ethyl)-5-(2-piperidino-ethyl)-1,2,4-oxadiazole, (Libexin)]. Acta Pharm Hung. 1968 Jun;38(2):68-70. Hungarian. PubMed PMID: 5723280.
18: Olivieri D, Pezza A, Polistina D, D'Agostino F. [Clinical evaluation of a new drug combination in the therapy of acute and chronic bronchopneumopathies]. Arch Monaldi. 1979 Jan-Apr;34(1-2):29-41. Italian. PubMed PMID: 554572.
19: Bártfai Z, Somoskövi A, Puhó EH, Czeizel AE. No teratogenic effect of prenoxdiazine: a population-based case-control study. Congenit Anom (Kyoto). 2007 Mar;47(1):16-21. PubMed PMID: 17300686.
20: Nosál'ová G, Strapková A, Korpás J. [Studies of the antitussive effect of prenoxdiazine of experimentally induced cough]. Bratisl Lek Listy. 1982 Jul;78(1):47-54. Slovak. PubMed PMID: 7127162.
