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MedKoo Cat#: 584127 | Name: Epigoitrin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Epigoitrin is the main bioactive constituent of an important traditional Chinese herbal medicine, Radix isatidis. The pharmacological effects of epigoitrin include antiviral, anticancer, and antithyroid activities.

Chemical Structure

Epigoitrin
Epigoitrin
CAS#1072-93-1

Theoretical Analysis

MedKoo Cat#: 584127

Name: Epigoitrin

CAS#: 1072-93-1

Chemical Formula: C5H7NOS

Exact Mass: 129.0248

Molecular Weight: 129.17

Elemental Analysis: C, 46.49; H, 5.46; N, 10.84; O, 12.39; S, 24.82

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 Weeks
10mg USD 450.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
Epigoitrin; Goitrine; (R)-Goitrin; (R) Goitrin; D-Goitrin; BA-51-090278; BA 51-090278; BA 51 090278; BA 51090278; BA51090278
IUPAC/Chemical Name
2-Oxazolidinethione, 5-vinyl-, (R)-
InChi Key
UZQVYLOFLQICCT-SCSAIBSYSA-N
InChi Code
InChI=1S/C5H7NOS/c1-2-4-3-6-5(8)7-4/h2,4H,1,3H2,(H,6,8)/t4-/m1/s1
SMILES Code
S=C1O[C@H](C=C)CN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 129.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ngai HL, Cheng SW, Tse TS, Lee HK, Shaw PC. Quality assessment of medicinal material Daqingye and Banlangen from Isatis tinctoria Fort. reveals widespread substitution with Strobilanthes species. PLoS One. 2025 May 7;20(5):e0323084. doi: 10.1371/journal.pone.0323084. PMID: 40334225; PMCID: PMC12058189. 2: Chang Y, Pan WJ, Wang SJ. Epigoitrin decreases synaptosomal glutamate release and protects neurons from glutamate excitotoxicity in rats. Eur J Pharmacol. 2025 Jul 5;998:177654. doi: 10.1016/j.ejphar.2025.177654. Epub 2025 Apr 23. PMID: 40280263. 3: Tang J, Ye L, Wang B. Absorption, distribution, metabolism, and excretion (ADME) of R,S-Goitrin in Radix Isatidis in rats by LC-MS/MS determination. Fitoterapia. 2025 Apr 4;183:106514. doi: 10.1016/j.fitote.2025.106514. Epub ahead of print. PMID: 40188993. 4: Li X, Li M, Chen R, Wang Y, Luo G, Gao X. Affinity-purified targets screening facilitates active components discovery of Chinese formula -HuGan tablets as a case. J Ethnopharmacol. 2025 May 12;347:119703. doi: 10.1016/j.jep.2025.119703. Epub 2025 Apr 4. PMID: 40188898. 5: Li Y, Fu KN, Wang S, Yang L, Wang ZT, Wang R, Shi YH. [Establishment of a quality grading standard of Isatidis Radix decoction pieces based on appearance traits and internal quality indexes]. Zhongguo Zhong Yao Za Zhi. 2024 Dec;49(24):6699-6712. Chinese. doi: 10.19540/j.cnki.cjcmm.20240910.201. PMID: 39805759. 6: Ochar K, Iwar K, Nair VD, Chung YJ, Ha BK, Kim SH. The Potential of Glucosinolates and Their Hydrolysis Products as Inhibitors of Cytokine Storms. Molecules. 2024 Oct 11;29(20):4826. doi: 10.3390/molecules29204826. PMID: 39459194; PMCID: PMC11510469. 7: Jeong S, Schütz V, Demir F, Preusche M, Huesgen P, Bigler L, Kovacic F, Gutbrod K, Dörmann P, Schulz M. Cyclic Isothiocyanate Goitrin Impairs Lotus japonicus Nodulation, Affects the Proteomes of Nodules and Free Mesorhizobium loti, and Induces the Formation of Caffeic Acid Derivatives in Bacterial Cultures. Plants (Basel). 2024 Oct 16;13(20):2897. doi: 10.3390/plants13202897. PMID: 39458844; PMCID: PMC11511026. 8: Hamsayegan S, Raissi H, Ghahari A. Selective detection of food contaminants using engineered gallium-organic frameworks with MD and metadynamics simulations. Sci Rep. 2024 Aug 5;14(1):18144. doi: 10.1038/s41598-024-69111-1. PMID: 39103470; PMCID: PMC11300645. 9: Arora R. Glucosinolates and Their Hydrolytic Products-A Love Story of Environmental, Biological, and Chemical Conditions. J AOAC Int. 2024 Oct 1;107(5):867-875. doi: 10.1093/jaoacint/qsae049. PMID: 38913875. 10: Li P, Yan Z, Shi P, Wang D, Liu Z, Lu M, Li C, Yin Y, Huang P. The Effects of Radix isatidis Raw Material on Egg Quality, Serum Biochemistry, Gut Morphology and Gut Flora. Antioxidants (Basel). 2023 Dec 7;12(12):2084. doi: 10.3390/antiox12122084. PMID: 38136205; PMCID: PMC10741118. 11: Kalath H, Koshy AJ, Banjan B, Soman S, Hosadevasthana G, Raju R, Rehman N, Revikumar A. In-silico studies of Brassica oleracea active compounds and their role in thyroid peroxidase activity. J Biomol Struct Dyn. 2024;42(22):12417-12433. doi: 10.1080/07391102.2023.2270601. Epub 2023 Oct 23. PMID: 37870072. 12: Panduang T, Phucharoenrak P, Karnpanit W, Trachootham D. Cooking Methods for Preserving Isothiocyanates and Reducing Goitrin in Brassica Vegetables. Foods. 2023 Oct 2;12(19):3647. doi: 10.3390/foods12193647. PMID: 37835300; PMCID: PMC10573036. 13: Ruan D, Yang J, Luo Q, Shi Y, Ding L, Wang Z, Wang R, Yang L. The Protective Effects of Goitrin on LPS-Induced Septic Shock in C57BL/6J Mice via Caspase-11 Non-Canonical Inflammasome Inhibition. Molecules. 2023 Mar 23;28(7):2883. doi: 10.3390/molecules28072883. PMID: 37049646; PMCID: PMC10096381. 14: Xu T, Gao X, Li Y, Lin C, Ma P, Bai Z, Zhou J, Wu H, Cao F, Wei P. Characterization of isolated starch from Isatis indigotica Fort. root and anhydro-sugars preparation using its decoction residues. Biomass Convers Biorefin. 2023 Feb 8:1-12. doi: 10.1007/s13399-023-03892-9. Epub ahead of print. PMID: 36785541; PMCID: PMC9907209. 15: Chen HY, Yao PF, Han YQ, Xu X, Xu J, Pan BY, Ouyang DS, Zhang TJ. ["Component-target-efficacy" network analysis and experimental verification of Qingkailing Oral Preparation]. Zhongguo Zhong Yao Za Zhi. 2023 Jan;48(1):170-182. Chinese. doi: 10.19540/j.cnki.cjcmm.20220920.401. PMID: 36725269. 16: Zhou C, Zhang H, Li F, Wang Y, Wang Y, Wang Z. Deficit mulched drip irrigation improved yield and quality while reduced water consumption of isatis indigotica in a cold and arid environment. Front Plant Sci. 2022 Sep 30;13:1013131. doi: 10.3389/fpls.2022.1013131. PMID: 36247605; PMCID: PMC9563244. 17: Li M, Xiao Y, Xiao L, Li Y, Jia M, Sun Y, Pan T, Zhou L, Li Y. Epigoitrin alleviates lipid and glucose metabolic disorders induced by a high-fat diet. Food Funct. 2022 Jul 4;13(13):7260-7273. doi: 10.1039/d2fo00242f. PMID: 35723416. 18: Min GY, Kim TI, Kim JH, Cho WK, Yang JH, Ma JY. Inhibitory effect of Isatis tinctoria L. water extract on DNCB-induced atopic dermatitis in BALB/c mice and HaCaT cells. Chin Med. 2022 Jun 8;17(1):66. doi: 10.1186/s13020-022-00624-5. PMID: 35676724; PMCID: PMC9175348. 19: Ma H, Xiao L, Xu D, Geng Y, Liu X, Chen Y, Wu Y. Non-Invasive Detection of Anti-Inflammatory Bioactivity and Key Chemical Indicators of the Commercial Lanqin Oral Solution by Near Infrared Spectroscopy. Molecules. 2022 May 5;27(9):2955. doi: 10.3390/molecules27092955. PMID: 35566303; PMCID: PMC9099839. 20: He X, Qiu H, Xie K, Wang Y, Hu J, Li F, An J. Effects of water saving and nitrogen reduction on the yield, quality, water and nitrogen use efficiency of Isatis indigotica in Hexi Oasis. Sci Rep. 2022 Jan 11;12(1):550. doi: 10.1038/s41598-021-04585-x. PMID: 35017618; PMCID: PMC8752745.