MedKoo Cat#: 561607 | Name: Temafloxacin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Temafloxacin is an antibiotic and antimycobacterial agent. It was approved to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections in 1992.

Chemical Structure

Temafloxacin
Temafloxacin
CAS#108319-06-8

Theoretical Analysis

MedKoo Cat#: 561607

Name: Temafloxacin

CAS#: 108319-06-8

Chemical Formula: C21H18F3N3O3

Exact Mass: 417.1300

Molecular Weight: 417.38

Elemental Analysis: C, 60.43; H, 4.35; F, 13.66; N, 10.07; O, 11.50

Price and Availability

Size Price Availability Quantity
5mg USD 400.00
10mg USD 600.00
25mg USD 950.00
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Related CAS #
No Data
Synonym
Temafloxacin; Omniflox;
IUPAC/Chemical Name
1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
InChi Key
QKDHBVNJCZBTMR-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
SMILES Code
O=C(C1=CN(C2=CC=C(F)C=C2F)C3=C(C=C(F)C(N4CC(C)NCC4)=C3)C1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 417.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Owens RC Jr, Ambrose PG. Antimicrobial safety: focus on fluoroquinolones. Clin Infect Dis. 2005 Jul 15;41 Suppl 2:S144-57. Review. PubMed PMID: 15942881. 2: Sprandel KA, Rodvold KA. Safety and tolerability of fluoroquinolones. Clin Cornerstone. 2003;Suppl 3:S29-36. Review. PubMed PMID: 14992418. 3: Ball P. Adverse drug reactions: implications for the development of fluoroquinolones. J Antimicrob Chemother. 2003 May;51 Suppl 1:21-7. Review. PubMed PMID: 12702700. 4: Archer JS, Archer DF. Oral contraceptive efficacy and antibiotic interaction: a myth debunked. J Am Acad Dermatol. 2002 Jun;46(6):917-23. Review. PubMed PMID: 12063491. 5: Rubinstein E. History of quinolones and their side effects. Chemotherapy. 2001;47 Suppl 3:3-8; discussion 44-8. Review. PubMed PMID: 11549783. 6: Mandell LA, Ball P, Tillotson G. Antimicrobial safety and tolerability: differences and dilemmas. Clin Infect Dis. 2001 Mar 15;32 Suppl 1:S72-9. Review. PubMed PMID: 11249832. 7: Bertino J Jr, Fish D. The safety profile of the fluoroquinolones. Clin Ther. 2000 Jul;22(7):798-817; discussion 797. Review. PubMed PMID: 10945507. 8: Goldstein EJ. Possible role for the new fluoroquinolones (levofloxacin, grepafloxacin, trovafloxacin, clinafloxacin, sparfloxacin, and DU-6859a) in the treatment of anaerobic infections: review of current information on efficacy and safety. Clin Infect Dis. 1996 Dec;23 Suppl 1:S25-30. Review. PubMed PMID: 8953103. 9: McGarvey WC, Singh D, Trevino SG. Partial Achilles tendon ruptures associated with fluoroquinolone antibiotics: a case report and literature review. Foot Ankle Int. 1996 Aug;17(8):496-8. Review. PubMed PMID: 8863030. 10: Muñiz AE. An unlikely childhood overdose: temafloxacin. Pediatr Emerg Care. 1996 Jun;12(3):215-6. Review. PubMed PMID: 8806150. 11: Ball P, Tillotson G. Tolerability of fluoroquinolone antibiotics. Past, present and future. Drug Saf. 1995 Dec;13(6):343-58. Review. PubMed PMID: 8652079. 12: Iakovlev SV, Iakovlev VP, Izotova GN. [Pharmacokinetics of fluoroquinolones in patients with renal insufficiency]. Antibiot Khimioter. 1995 Oct;40(10):39-47. Review. Russian. PubMed PMID: 8660120. 13: Moran JS, Levine WC. Drugs of choice for the treatment of uncomplicated gonococcal infections. Clin Infect Dis. 1995 Apr;20 Suppl 1:S47-65. Review. PubMed PMID: 7795109. 14: Nord CE. Effect of quinolones on the human intestinal microflora. Drugs. 1995;49 Suppl 2:81-5. Review. PubMed PMID: 8549421. 15: Appelbaum PC. Quinolone activity against anaerobes: microbiological aspects. Drugs. 1995;49 Suppl 2:76-80. Review. PubMed PMID: 8549420. 16: Lietman PS. Fluoroquinolone toxicities. An update. Drugs. 1995;49 Suppl 2:159-63. Review. PubMed PMID: 8549287. 17: Blum MD, Graham DJ, McCloskey CA. Temafloxacin syndrome: review of 95 cases. Clin Infect Dis. 1994 Jun;18(6):946-50. Review. PubMed PMID: 8086558. 18: Rodvold KA, Piscitelli SC. New oral macrolide and fluoroquinolone antibiotics: an overview of pharmacokinetics, interactions, and safety. Clin Infect Dis. 1993 Aug;17 Suppl 1:S192-9. Review. PubMed PMID: 8399914. 19: Fass RJ. Aetiology and treatment of community-acquired pneumonia in adults: an historical perspective. J Antimicrob Chemother. 1993 Jul;32 Suppl A:17-27. Review. PubMed PMID: 8407696. 20: Leigh DA. Prostatitis--an increasing clinical problem for diagnosis and management. J Antimicrob Chemother. 1993 Jul;32 Suppl A:1-9. Review. PubMed PMID: 8407691.