Synonym
Acedapsone; Acetamin; Atilon; Camilan; Rodilon; BA 2650; BA-2650; BA2650
IUPAC/Chemical Name
N,N'-Diacetyl-4,4'-diaminodiphenylsulfone
InChi Key
AMTPYFGPPVFBBI-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20)
SMILES Code
O=S(C1=CC=C(NC(C)=O)C=C1)(C2=CC=C(NC(C)=O)C=C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
332.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Olivares Sabournin R, González Segredo AB. [Bacteriologic study in patients with multibacillary leprosy treated with rifampicin and acedapsone]. Rev Cubana Med Trop. 1989 May-Aug;41(2):307-12. Spanish. PubMed PMID: 2486227.
2: George J, Balakrishnan S. Blood dapsone levels in leprosy patients treated with acedapsone. Indian J Lepr. 1986 Jul-Sep;58(3):401-6. PubMed PMID: 3794408.
3: Neelan PN, Sirumban P, Sivaprasad N. Limited duration acedapsone prophylaxis in leprosy. Indian J Lepr. 1986 Apr-Jun;58(2):251-6. PubMed PMID: 3543161.
4: Russell DA, Worth RM, Jano B, Fasal P, Shepard CC. Acedapsone in the prevention of leprosy: field trial in three high prevalence villages in Micronesia. Am J Trop Med Hyg. 1979 May;28(3):559-63. PubMed PMID: 453449.
5: Peters JH, Murray JF Jr, Gordon GR, Levy L, Russell DA, Scott GC, Vincin DR, Shepard CC. Acedapsone treatment of leprosy patients: response versus drug disposition. Am J Trop Med Hyg. 1977 Jan;26(1):127-36. PubMed PMID: 842774.
6: Levy L, Peters JH. Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. Antimicrob Agents Chemother. 1976 Jan;9(1):102-12. PubMed PMID: 769667; PubMed Central PMCID: PMC429483.
7: Russell DA, Shepard CC, McRae DH, Scott GC, Vincin DR. Acedapsone (DADDS) treatment of leprosy patients in the Karimui of Papua New Guinea: status at six years. Am J Trop Med Hyg. 1975 May;24(3):485-95. PubMed PMID: 1098496.
